DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and AgaP_AGAP000355

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	XP_310757.4	Gene:	AgaP_AGAP000355 / 1271902	VectorBaseID:	AGAP000355	Length:	484	Species:	Anopheles gambiae

Alignment Length:	481	Identity:	169/481 - (35%)
Similarity:	221/481 - (45%)	Gaps:	146/481 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SQTICRYYVRGICRFGELCRFSHDLSRGRPECEEQVATDVLPKPSTSSSSTIGSRSASISSQQRN 83
            :|.:||:|..|.||||..|||.|      |..|          |:|..||...|.|:::...:
Mosquito    13 AQIVCRFYQYGTCRFGSTCRFIH------PAAE----------PATLGSSCSSSTSSAVDLSR-- 59

  Fly    84 WANAPVFVP-------------------------------------------------SQKRYTA 99
            |.:||||||                                                 ||::...
Mosquito    60 WIDAPVFVPKAKLPLEQPPQPPQQQQQLPPRKSKRKSDRRTVMVDESQLQLRRTRMDMSQQQQVE 124

  Fly   100 HEQSE---FETTVDPEAVMEAQ-----------------------------AGASYDTLA----P 128
            .|.:|   .|..:|.||..||.                             |....|..|    |
Mosquito   125 QEDTEEKPDEVGLDNEADNEADNEEEEDEEEEQEEEEEEEAEEEEESDGGGAVGGLDAAAAAGSP 189

  Fly   129 GVSWAEVVGGPSSLNKEDYGEENSSCAWGEF---------------SAYPIHMELCEMCDQYCLH 178
            .:|:|.||    ::|....|.|......||.               ....:|.||||:|.:|||.
Mosquito   190 LLSYANVV----TMNNNHNGTEPEVGPAGEVRLCAHYEKHGLCPLADCVHVHGELCELCQRYCLD 250

  Fly   179 PTDQVQRRSHNRECLQQHEQAMELSFAIARSKDKTCGICFDTIMEKAGREKRFGILPNCNHIFCL 243
            |.|:.|:|.||.:|:::||..||.:||:.||:||:||||.|.:|||..||:||||||||.|.|||
Mosquito   251 PRDREQQRRHNADCIREHELEMEHAFAVQRSRDKSCGICLDVVMEKRAREQRFGILPNCKHTFCL 315

  Fly   244 ECIRTWRQAKQFENKITRACPECRVCSDFVCPSAFWMETKEEKDKLLNDYRAALGAKDCKYFKKG 308
            .||||||:|..|.|||.|.||.|||.|||||||..|:|..|||::|:.:|:.|....||.:||||
Mosquito   316 SCIRTWRKATNFANKIRRGCPTCRVPSDFVCPSFVWVEAGEEKERLIENYKQACNNTDCMHFKKG 380

  Fly   309 EGKCPFGNKCFYKHALPNGDIVDVGLPKRTRK-----------LQSQNEIIDLL---DIYLWDYV 359
            ...|||||||||:||||:|::||:|.|.|.|.           |..|..:..||   .:.|.|
Mosquito   381 AANCPFGNKCFYRHALPSGELVDLGAPSRRRNPNRAARGHIDPLPLQEVLAALLARRSLALHD-- 443

  Fly   360 DRRDYHWLEMISSDITSSESSDYSDE 385
                    |:::|..:..:.|||..|
Mosquito   444 --------ELLTSLFSDLDDSDYDLE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	13/22 (59%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	36/53 (68%)
AgaP_AGAP000355	XP_310757.4	ZnF_C3H1	16..36	CDD:214632	12/25 (48%)
AgaP_AGAP000355	XP_310757.4	RING	286..341	CDD:238093	38/54 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I14058
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I5109
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D116581at6656
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		otm50347
Panther	1	1.100	-	-	LDO	PTHR11224
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X837
TreeFam	1	0.960	-	-
	12	11.940