DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mkrn1 and TMC6

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_001120670.1	Gene:	TMC6 / 11322	HGNCID:	18021	Length:	805	Species:	Homo sapiens

Alignment Length:	146	Identity:	41/146 - (28%)
Similarity:	62/146 - (42%)	Gaps:	32/146 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RPECEEQVATDVLPKPSTSSSSTIG-SRSASISS------QQRNWANAPV---FV----PSQKRY 97
            |||..:..||  |...::..|.||| ||.|.||.      |.|..::.|:   ||    ||.:.|
Human    69 RPEGTQSTAT--LRILASMPSRTIGRSRGAIISQYYNRTVQLRCRSSRPLLGNFVRSAWPSLRLY 131

  Fly    98 ------TAHEQSEFETTVDPEAVMEAQAGASYDTLAPGVSWAEVVGGPSSLNKEDYGEENSSCAW 156
                  ||.|:.|.::.:..|  :::.|.|..|.:..|:        |.||.::....|.|....
Human   132 DLELDPTALEEEEKQSLLVKE--LQSLAVAQRDHMLRGM--------PLSLAEKRSLREKSRTPR 186

  Fly   157 GEFSAYPIHMELCEMC 172
            |::...|....:|..|
Human   187 GKWRGQPGSGGVCSCC 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093
TMC6	NP_001120670.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		TMC	540..646	CDD:400250
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..805
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900