DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mkrn1 and mkrn1

DIOPT Version :9

Sequence 1:	NP_001246867.1	Gene:	Mkrn1 / 44131	FlyBaseID:	FBgn0029152	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	XP_004912513.1	Gene:	mkrn1 / 100485650	XenbaseID:	XB-GENE-959144	Length:	451	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	159/422 - (37%)
Similarity:	212/422 - (50%)	Gaps:	96/422 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RSQTICRYYVRGICRFGELCRFSHDLSRGRPECEEQVATDVLPK--PSTS---SSSTIGSRSASI 77
            ||..||||:.||.|.:|:.||:.|.    :|..|:.:......:  ||.|   .||.|.|::|.:
Frog    64 RSTMICRYFQRGCCAYGDRCRYEHT----KPLKEDLIGNTSTARSWPSESPAEPSSNINSKAAEL 124

  Fly    78 SS--------QQRNWANAPVFVPSQ-------KRYTAHEQSE---FETTVDPEAVMEAQAGASYD 124
            ::        |..:|.||..|||.|       ..||...|.|   .|...|||...:
Frog   125 AASELAAGGPQAEDWVNAVEFVPGQLYSGRAPDAYTQGTQKEDECREQPADPELKKQ-------- 181

  Fly   125 TLAPGVSWAEVVGGPSSLNKEDYGEENSSCAWGEFSAYPIHMELCEMCDQYCLHPTDQVQRRSHN 189
             |.|   :|.|            ||    |.:||...| :|.:.|:||....|||.|..||..|.
Frog   182 -LCP---YAAV------------GE----CRYGENCVY-LHGDPCDMCGLQVLHPVDTAQRSQHI 225

  Fly   190 RECLQQHEQAMELSFAIARSKDKTCGICFDTIMEKAG-REKRFGILPNCNHIFCLECIRTWRQAK 253
            :.|::.||:.||||||:.||||..||||.:.:.||.. .|:|||||.||:|.:||:|||.||.||
Frog   226 KSCIEAHEKDMELSFAVQRSKDIVCGICMEVVYEKTNPGERRFGILSNCSHSYCLKCIRKWRSAK 290

  Fly   254 QFENKITRACPECRVCSDFVCPSAFWMETKEEKDKLLNDYRAALGAKDCKYFKKGEGKCPFGNKC 318
            |||:||.::|||||:.|:||.||.:|:|.||||.||:..|:.|:..|.|:||.:|.|.||||..|
Frog   291 QFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKSCRYFDEGRGTCPFGGNC 355

  Fly   319 FYKHALPNGDIVD------VGLPKRTRKLQSQNEIIDLLDIYLWDYVDRRD-------------- 363
            |||||.|:|.|.:      .|:..|.|. |.:|.        .||: |.||
Frog   356 FYKHAYPDGRIEEPQPRQKSGMSSRYRS-QRRNR--------FWDF-DERDGADPFENDEDEVVT 410

  Fly   364 YHWLEMI--------SSDITSSESS-DYSDED 386
            :...||:        ..|:|.||.. |:..:|
Frog   411 FELGEMLLMLLAAGADEDLTDSEDEWDFFHDD 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mkrn1	NP_001246867.1	ZnF_C3H1	20..43	CDD:214632	11/22 (50%)
Mkrn1	NP_001246867.1	RING	213..267	CDD:238093	32/54 (59%)
mkrn1	XP_004912513.1	YTH1	<35..>92	CDD:227416	14/31 (45%)
		zf-CCCH_4	68..87	CDD:375512	10/18 (56%)
		PHA03096	<190..339	CDD:222981	79/153 (52%)
		RING-HC_MKRN1_3	247..307	CDD:319644	35/59 (59%)
		RING-HC finger (C3HC4-type)	250..303	CDD:319644	31/52 (60%)
		MKRN1_C	369..436	CDD:374139	16/76 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8364
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32175
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3142
OMA	1	1.010	-	-		QHG58455
OrthoDB	1	1.010	-	-		D1388677at2759
OrthoFinder	1	1.000	-	-		FOG0000752
OrthoInspector	1	1.000	-	-		mtm9499
Panther	1	1.100	-	-	LDO	PTHR11224
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080