DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and MYOM2

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_003961.3	Gene:	MYOM2 / 9172	HGNCID:	7614	Length:	1465	Species:	Homo sapiens

Alignment Length:	1288	Identity:	246/1288 - (19%)
Similarity:	416/1288 - (32%)	Gaps:	424/1288 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIRANA 133
            |||.||| :|...|..||..|    :::....:.|:|..|..:|.|.|......|.|.  :..||
Human   185 VQWYKDG-SLICQAAEPGKYR----IESNYGVHTLEINRADFDDTATYSAVATNAHGQ--VSTNA 242

  Fly   134 KLSI------------VAAPSSIVIEGYARNARVEVE-----------ERQNLTLHCI------A 169
            .:.:            |..|..:.:.........:|:           |.:.:||.|.      .
Human   243 AVVVRRFRGDEEPFRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDL 307

  Fly   170 ENANPAAEIVWFQGEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCE-------AR 227
            :...|.||  |::.:|.:..:....:.....:...:.|.||     :||...::..       :.
Human   308 KRVQPRAE--WYRDDVLLKESKWTKMFFGEGQASLSFSHLH-----KDDEGLYTLRIVSRGGVSD 365

  Fly   228 HKAL------------PPDVPMRAQVQ------LSVLYPPGAPFFEGYSQGETLHR---GQEVQI 271
            |.|.            .|..||..|..      :.|.:.|.....|....|..:.|   |....:
Human   366 HSAFLFVRDADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWV 430

  Fly   272 ACRSRGGNPPAQLTWYR-----------------NGVAISSPQRTSG----------RLSENVY- 308
            .|    .:.|.::..|.                 |...||.|.|.|.          |..:.|:
Human   431 QC----NDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRLQAVHL 491

  Fly   309 ---KFTAAAEDN------------GANLVCEAKNLLATT---PLRAELNLTVLYAPKDVYLSGAN 355
               |..|..:|:            |.:....::|.:..:   |.....:..:.:..|.|..||:.
Human   492 EGEKEIAIYQDDLEGDAQVPGPPTGVHASEISRNYVVLSWEPPTPRGKDPLMYFIEKSVVGSGSW 556

  Fly   356 QAKVGDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFI 420
            |       :::..||..:|:..:...:.|:   :..::..|::..|....|.|:..|.:|..|.:
Human   557 Q-------RVNAQTAVRSPRYAVFDLMEGK---SYVFRVLSANRHGLSEPSEITSPIQAQDVTVV 611

  Fly   421 A---------------------------------------------------------VCHALNT 428
            .                                                         |.|.|.|
Human   612 PSAPGRVLASRNTKTSVVVQWDRPKHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYNRFVVHGLTT 676

  Fly   429 --------------ELTQNVVGSHTVNV---LYPPSPPL-LTGYN-DGDILISG-SILKLQCSSA 473
                          .:::|...|..:.|   |..||.|. :|..| ||..:..| .:.|.    :
Human   677 GEQYIFRVKAVNAVGMSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKF----S 737

  Fly   474 GGNPPPTLQWYKNDKIINAPS-KLVDSKITSELSLLVNASDNNAIYKCKVQNAAIDIPLFATKTL 537
            ||:  |.|.:|.:.:.::..: ..|:|..:....|.|:.....::|:.|:  ||:::       .
Human   738 GGS--PILGYYLDKREVHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKI--AAVNL-------A 791

  Fly   538 GV--------HFPPETVKISVVPKNLVPGIRAKL-ICDSSSSNPPAKISWWKDGI-----PVEGL 588
            |:        ||..|.   ..:|:   ||....| .|:...:   :.:..||..:     ||.|.
Human   792 GIGEPSDPSEHFKCEA---WTMPE---PGPAYDLTFCEVRDT---SLVMLWKAPVYSGSSPVSGY 847

  Fly   589 NLANR---PGLW--GGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFET 648
            .:..|   .|.|  ....:|...|:.::....|..|..:      .|:|:..   .:..|.....
Human   848 FVDFREEDAGEWITVNQTTTASRYLKVSDLQQGKTYVFR------VRAVNAN---GVGKPSDTSE 903

  Fly   649 PQSTTFVGVEGAPFHVELLA----SGNPMV----------ITYTWTKDGLPISSNSLSGQRLISD 699
            |     |.||..|...|:.|    .||..:          ..:||.|....||.:.......:.|
Human   904 P-----VLVEARPGTKEISAGVDEQGNIYLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGD 963

  Fly   700 GPRLNISRLSRNDAGVYICEALNSQGTAL--------LEIQVAVEYA---PTITAVSEGRSFVAG 753
            ..:|.:....:.|.|.|.....::.|.:.        ||..:|:...   |||...||
Human   964 HSKLYLKNPDKEDLGTYSVSVSDTDGVSSSFVLDPEELERLMALSNEIKNPTIPLKSE------- 1021

  Fly   754 EPAVLACHIQARP-----LEAAHVRWSRDG---YDLATRTISSFE-------NGTALLQIA---- 799
                ||..|..:.     |:|.|:  |.|.   :.:..|.:|..|       ..|.::::.
Human  1022 ----LAYEIFDKGRVRFWLQAEHL--SPDASYRFIINDREVSDSEIHRIKCDKATGIIEMVMDRF 1080

  Fly   800 SVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTA-----PEID---------HSPGFTRY-----A 845
            |:|..  |.:|  |....|...:|:.|:::..|     .|.:         ..|.|..|     .
Human  1081 SIENE--GTYT--VQIHDGKAKSQSSLVLIGDAFKTVLEEAEFQRKEFLRKQGPHFAEYLHWDVT 1141

  Fly   846 ARLGVRAQLICR-SLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDY 909
            ....||  |:|: :....:..|.|.   ||..:.......::||.:      ..|||...|..|:
Human  1142 EECEVR--LVCKVANTKKETVFKWL---KDDVLYETETLPNLERGI------CELLIPKLSKKDH 1195

  Fly   910 GQYECVVRNSLGQASTTLEFSKPSRPDAPLQL-RVGNVSDTGVDLNWTP-GFD------------ 960
            |:|:..:::..||..:.||.:.....|..|.: ||...|.:.:.:..|| |..
Human  1196 GEYKATLKDDRGQDVSILEIAGKVYDDMILAMSRVCGKSASPLKVLCTPEGIRLQCFMKYFTDEM 1260

  Fly   961 -------------------GGMQTYFRLRLKQHGE-DKYKYV----DAKPGHQNISLDGLKPGAT 1001
                               ||.:....|::.:..| ||.||.    |.|..||. |||
Human  1261 KVNWCHKDAKISSSEHMRIGGSEEMAWLQICEPTEKDKGKYTFEIFDGKDNHQR-SLD------- 1317

  Fly  1002 YYFSVMAANEAGGSKFMPDIKLTLSKGSQPHSAEYTEKDE------LPNVMII 1048
              .|..|.:||            .::..|..:|.:.||:.      ||:|:.|
Human  1318 --LSGQAFDEA------------FAEFQQFKAAAFAEKNRGRLIGGLPDVVTI 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	17/52 (33%)
		IG_like	45..137	CDD:214653	21/67 (31%)
		Ig	153..231	CDD:299845	16/101 (16%)
		IG_like	258..342	CDD:214653	20/132 (15%)
		Ig	266..327	CDD:299845	16/103 (16%)
		IG_like	357..>414	CDD:214653	9/56 (16%)
		Ig	360..427	CDD:299845	13/123 (11%)
		Ig	<468..526	CDD:299845	11/58 (19%)
		I-set	547..633	CDD:254352	18/96 (19%)
		Ig	556..631	CDD:299845	16/85 (19%)
		I-set	644..735	CDD:254352	22/112 (20%)
		IGc2	668..725	CDD:197706	13/70 (19%)
		IG_like	751..829	CDD:214653	20/96 (21%)
		IGc2	753..815	CDD:197706	17/80 (21%)
		Ig	852..928	CDD:143165	17/76 (22%)
		FN3	935..1017	CDD:238020	27/119 (23%)
MYOM2	NP_003961.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..61
		I-set	154..246	CDD:254352	21/67 (31%)
		Ig	171..242	CDD:143165	19/63 (30%)
		IG_like	290..372	CDD:214653	16/88 (18%)
		IGc2	291..354	CDD:197706	14/69 (20%)
		FN3	383..475	CDD:238020	19/95 (20%)
		FN3	511..603	CDD:238020	16/101 (16%)
		FN3	612..702	CDD:238020	6/89 (7%)
		FN3	711..801	CDD:238020	23/104 (22%)
		FN3	813..903	CDD:238020	19/101 (19%)
		IG_like	<940..995	CDD:214653	11/54 (20%)
		Ig	<942..995	CDD:299845	11/52 (21%)
		Ig_M-protein_C	1344..1435	CDD:143299	4/13 (31%)
		I-set	1347..1435	CDD:254352	4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1442..1465
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000