DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and IGFN1

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001158058.1	Gene:	IGFN1 / 91156	HGNCID:	24607	Length:	3708	Species:	Homo sapiens

Alignment Length:	986	Identity:	200/986 - (20%)
Similarity:	326/986 - (33%)	Gaps:	302/986 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEE 159
            |.:.:.|. :.::||....:.|:    |..|:.:..|.       .|.....:|.   |.:||:.
Human  2877 DGRLDIYG-ERRDATRSSTSRYK----PGTGSFSKDAQ-------GPMGHFSQGL---ADMEVQP 2926

  Fly   160 RQNLTLHC-IAENANPAAEIVWFQGEVPVSTAP--------------IVTVNQTAPKRFT----- 204
            .:..||.| :..:..|.   .||:..|.::|..              |..|..|...|:|
Human  2927 GEAATLSCTLTSDLGPG---TWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTFVAGD 2988

  Fly   205 --TSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQ 267
              :.:||.:|.              ...:.|||..:.:..|.|  ..|.|..
Human  2989 QQSEATLTVQD--------------SPTIAPDVTEKLREPLVV--KAGKPVI------------- 3024

  Fly   268 EVQIACRSRGGNPPAQLTWYRNGV-AISSPQR----------------TSGRLSENVYKFTAAAE 315
             |:|..:|   :.|.|..|.::|. .:.|..|                ::||.....|..|..:|
Human  3025 -VKIPFQS---HLPIQAAWRKDGAEVVGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYSVTLRSE 3085

  Fly   316 DNGANLVCEAKNLLATTPLRAELNLTVLYAP---------KDVYLSGA------NQAKVGDSVQL 365
            ...               ::|||.|.|:..|         :|.:.:|.      .:...|.:|:
Human  3086 GGS---------------VQAELTLQVIDKPDPPQGPMEVQDCHRAGVCLRWRPPRDNGGRTVE- 3134

  Fly   366 SCVTAPSNPQARISW-SINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALNTE 429
             |.........|.:| .:...|.|::|:.......|                |.:.....|:.:|
Human  3135 -CYVVERRQAGRSTWLKVGEAPADSTTFTDAHVEPG----------------RKYTFRVRAVTSE 3182

  Fly   430 LTQNVVGSHTVNVL------YPPSPPLLTGYNDGDILI--------SGSIL--KLQCSSAGGN-- 476
            .....:.|..:.|.      .|.:|.:|:..:.|..|.        |..||  .::....|.|
Human  3183 GAGEALESEEILVAPEALPKAPSAPAILSASSQGITLTWTAPRGPGSAHILGYLIERRKKGSNTW 3247

  Fly   477 ------PPPTLQWYKNDKIINAPSKLVDSKITSELSLLVNASDNNAIYKCKVQNAAIDIPLFATK 535
                  |.|..:|           .:.|.:             ....|:.:|...|...|
Human  3248 TAVNDQPVPERRW-----------TVADVR-------------QGCQYEFRVTAVAPSGP----- 3283

  Fly   536 TLGVHFPPETVKIS---VVPKNLVPGIRAKLICDSSSSNPPAKISW----WKDGIPVEG--LNLA 591
              |...||.....:   :.|..||..::.     :..||....:||    .::|...:|  :.|.
Human  3284 --GEPGPPSDAVFARDPMRPPGLVRNLQV-----TDRSNTSITLSWAGPDTQEGDEAQGYVVELC 3341

  Fly   592 NRPGL-W-GGSVSTLEMYVNITQDL---DGIVYTCQSHNE--VLQRSVHETI--SLDILYPPKFE 647
            :...| | ...|.|:.:.....:.|   :|......:.||  ..|.|..:|:  ::.:...|||.
Human  3342 SSDSLQWLPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLVQAMPVTVCPKFL 3406

  Fly   648 TPQST-TFVGVE-GAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDG-PRLNISRLS 709
            ...|| ..:.|: |....|.:.....||. ..||.|||||:...|::   :..|| .:|.|....
Human  3407 VDSSTKDLLTVKVGDTVRVPVSFEAMPMP-EVTWLKDGLPLPKRSVT---VTKDGLTQLLIPVAG 3467

  Fly   710 RNDAGVYICEALNSQGTAL---LEIQVAV-----------EYAP-TITAVSEGRSFVAGEPAVLA 759
            .:|:|:|.......||..:   ..|:||.           |..| |:||..|..   ..|...:.
Human  3468 LSDSGLYTVVLRTLQGKEVAHSFRIRVAACPQAPGPIHLQENVPGTVTAEWEPS---PDEAQDVP 3529

  Fly   760 CHIQARPLEAAHVRWSR----------------DGYDLATRTISSFENGTALLQIASVERSDIGN 808
            .|.......:||..|..                .|::...|.::..|.|.:       :.||...
Human  3530 LHYAVFTRSSAHGPWHEAADRIHTNRFTLLGILPGHEYHFRVVAKNELGAS-------KPSDTSQ 3587

  Fly   809 FTCIVDNQRG-----APAAQNVLLVVQTAPEIDHSPGFTRYAARLGVRAQLI------CRSLA-- 860
            ..|| ..||.     ||..:.        |::...|.|.     :|:|:.|:      |.|.|
Human  3588 PWCI-PRQRDRFTVKAPCYRE--------PDLSQKPRFL-----VGLRSHLLPQGCECCMSCAVQ 3638

  Fly   861 -SPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYECVVRNSLGQA- 923
             ||:|...|.::.:.|      :........|.|.. .:|.|.:.||.|.|:|:.|..|:||||
Human  3639 GSPRPHVTWFKNDRSL------EGNPAVYSTDLLGV-CSLTIPSVSPKDSGEYKAVAENTLGQAV 3696

  Fly   924 -STTLEFSKPS 933
             :.||...:||
Human  3697 STATLIVIEPS 3707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	5/26 (19%)
		IG_like	45..137	CDD:214653	8/41 (20%)
		Ig	153..231	CDD:299845	19/99 (19%)
		IG_like	258..342	CDD:214653	18/100 (18%)
		Ig	266..327	CDD:299845	14/77 (18%)
		IG_like	357..>414	CDD:214653	9/57 (16%)
		Ig	360..427	CDD:299845	11/67 (16%)
		Ig	<468..526	CDD:299845	8/65 (12%)
		I-set	547..633	CDD:254352	20/101 (20%)
		Ig	556..631	CDD:299845	17/87 (20%)
		I-set	644..735	CDD:254352	29/96 (30%)
		IGc2	668..725	CDD:197706	17/57 (30%)
		IG_like	751..829	CDD:214653	17/98 (17%)
		IGc2	753..815	CDD:197706	13/77 (17%)
		Ig	852..928	CDD:143165	25/86 (29%)
		FN3	935..1017	CDD:238020
IGFN1	NP_001158058.1	I-set	29..120	CDD:254352
		Ig	46..120	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..81
		I-set	309..395	CDD:254352
		I-set	2914..2997	CDD:254352	19/88 (22%)
		Ig	2930..2998	CDD:143165	15/70 (21%)
		I-set	3005..3097	CDD:254352	25/125 (20%)
		Ig	3017..3104	CDD:299845	23/120 (19%)
		FN3	3101..3193	CDD:238020	16/109 (15%)
		FN3	3201..3278	CDD:238020	16/100 (16%)
		FN3	3302..3388	CDD:238020	18/90 (20%)
		IG_like	3415..3494	CDD:214653	23/82 (28%)
		Ig	3422..3494	CDD:299845	21/75 (28%)
		FN3	3498..3587	CDD:238020	17/98 (17%)
		I-set	3614..3703	CDD:254352	30/100 (30%)
		Ig	3633..3700	CDD:143165	22/73 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000