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Protein Alignment hbs and HMCN1

DIOPT Version :10

Sequence 1:	NP_788355.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0287864	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_114141.2	Gene:	HMCN1 / 83872	HGNCID:	19194	Length:	5635	Species:	Homo sapiens

Alignment Length:	1024	Identity:	252/1024 - (24%)
Similarity:	405/1024 - (39%)	Gaps:	159/1024 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QVAAPPVQKFHLTPHDLQILEGTDTLLRCEVSNR-AGKVQWTKDGFALGFSAVIPGFPRYSVLVD 95
            ||.|||.....:...::.:|:|:.|.:.|..... |..:.|.:||..||..|.:          .
Human  3429 QVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL----------T 3483

  Fly    96 AKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEER 160
            ...:...||:..|..||..:|.|.....||.  :..:..|.::..|.   |.|...:..:.|...
Human  3484 VSTHGMVLQLLKAETEDSGKYTCIASNEAGE--VSKHFILKVLEPPH---INGSEEHEEISVIVN 3543

  Fly   161 QNLTLHCIAENANPAAEIVWFQGEVPV-STAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSC 224
            ..|.|.|||... ||.::.|.:...|: .|..:.|:......|.:|:..        :|...::|
Human  3544 NPLELTCIASGI-PAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQV--------EDTGRYTC 3599

  Fly   225 EARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGE--TLHRGQEVQIACRSRGGNPPAQLTWY 287
            .|...|...|.....:|.:    ||.   ..|..:..  |:.|.::|.:.|:| ...||..:||.
Human  3600 LASSPAGDDDKEYLVRVHV----PPN---IAGTDEPRDITVLRNRQVTLECKS-DAVPPPVITWL 3656

  Fly   288 RNGVAISSPQRTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLS 352
            |||..:.:..|..........:...|...:.||..|.|.|:...|  ..|..|||...|.   :.
Human  3657 RNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKT--TREFILTVNVPPN---IK 3716

  Fly   353 GANQAKV---GDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDS 414
            |..|:.|   ..|..|.|: |...|..||:|                ..||..::.::...:|..
Human  3717 GGPQSLVILLNKSTVLECI-AEGVPTPRITW----------------RKDGAVLAGNHARYSILE 3764

  Fly   415 QSRTFIAVCHALNTE----LTQNVVGSH----TVNVLYPPSPPLLTGYNDGDILISGSILKLQCS 471
            .....|...|..:|.    :..|..|:.    .:.|..|||  :..|..:..::::.. ..|.|
Human  3765 NGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS--IAPGPTNMTVIVNVQ-TTLAC- 3825

  Fly   472 SAGGNPPPTLQWYKNDKIINAPSKLVDSKITSELSLLV--NASDNNAIYKCKVQNAAIDIPLFAT 534
            .|.|.|.|::.|.||..::|........::.|..||::  .:.|:.|.|:|.|.|.|.|..  .|
Human  3826 EATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDK--RT 3888

  Fly   535 KTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPP-AKISWWKDGIPV----EGLNLANRP 594
            ..|.|..||   .|:..|.:.:....|..:...::|..| ..|.|.|:||.:    :|..:
Human  3889 VDLTVQVPP---SIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRI---- 3946

  Fly   595 GLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVGVEG 659
             |..|::..|...:|....     |||.:.|..  .|.|..::|.:..||..: ||.:....:..
Human  3947 -LSSGAIEILATQLNHAGR-----YTCVARNAA--GSAHRHVTLHVHEPPVIQ-PQPSELHVILN 4002

  Fly   660 APFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQ 724
            .|..:...|:|.|... .||.|:|:.::::..:...|.|.|  |.|||..|.|||.|:|.|.|..
Human  4003 NPILLPCEATGTPSPF-ITWQKEGINVNTSGRNHAVLPSGG--LQISRAVREDAGTYMCVAQNPA 4064

  Fly   725 GTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDG----YDLATRT 785
            ||||.:|::.|:..|.|:...:.......:|..|:|  :|..|....:.|.:||    ..:..|.
Human  4065 GTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSC--EADGLPPPDITWHKDGRAIVESIRQRV 4127

  Fly   786 ISSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGFTRYAARLGV 850
            :||     ..||||.|:..|.|::||:..|..|: ::.:..|.|...|.|..:.|  .|......
Human  4128 LSS-----GSLQIAFVQPGDAGHYTCMAANVAGS-SSTSTKLTVHVPPRIRSTEG--HYTVNENS 4184

  Fly   851 RAQLICRSLASPQPSFIWRRHGKD--LKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYE 913
            :|.|.|.:...|.|:..|:   ||  |......|:.:..        ...|::||...:|.|.|.
Human  4185 QAILPCVADGIPTPAINWK---KDNVLLANLLGKYTAEP--------YGELILENVVLEDSGFYT 4238

  Fly   914 CVVRNSLGQASTTLEFSKPSRP-------DAPL----QLRVGNVSDTGV---DLNWTPGFDGGMQ 964
            ||..|:.|:.:.|:..:....|       |..|    |||: :...||:   .|.||  |:..:
Human  4239 CVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRL-SCKATGIPLPKLTWT--FNNNI- 4299

  Fly   965 TYFRLRLKQHGEDKYKYVDAKPGHQNISLDGLKPGATYYFSVMAANEAG 1013
                  :..|       .|:..||..:.::.:....:..:...|.|..|
Human  4300 ------IPAH-------FDSVNGHSELVIERVSKEDSGTYVCTAENSVG 4335

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.