DRSC/TRiP Functional Genomics Resources

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Protein Alignment hbs and NECTIN1

DIOPT Version :10

Sequence 1:NP_788355.1 Gene:hbs / 44129 FlyBaseID:FBgn0287864 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_002846.3 Gene:NECTIN1 / 5818 HGNCID:9706 Length:517 Species:Homo sapiens


Alignment Length:528 Identity:102/528 - (19%)
Similarity:175/528 - (33%) Gaps:181/528 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 GTDTLLRCEVSN-----RAGKVQWTKD-----------GFALGFSAVIPGFPRYSVLVDAKQNAY 101
            |||.:|.|..:|     :..:|.|.|.           ..::|.|.:.|    |...|:..:.::
Human    44 GTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAP----YRERVEFLRPSF 104

  Fly   102 ---NLQIKNATLEDDAEYQCQVGP-AAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEV-EERQ 161
               .:::....|||:..|.|:... ..||...:.|  |:::|.|:: .|||.....|.:. ::.:
Human   105 TDGTIRLSRLELEDEGVYICEFATFPTGNRESQLN--LTVMAKPTN-WIEGTQAVLRAKKGQDDK 166

  Fly   162 NLTLHCIAENANPAAEIVW---FQGEV-------PVSTAPIVTVNQTAPKRFTTSSTL------H 210
            .|...|.:.|..|.:.:.|   .:||.       |..|..:::..:..|.|.....:|      |
Human   167 VLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYH 231

  Fly   211 LQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRS 275
            :     |.:||                  .:.|:|.|.|... .||:.....|.| .:|::.|::
Human   232 M-----DRFKE------------------SLTLNVQYEPEVT-IEGFDGNWYLQR-MDVKLTCKA 271

  Fly   276 RGGNPPA-QLTWYR-NG---VAISSPQRT---SGRLSENVYKFTAAAEDNGANLVCEAKNLLATT 332
             ..|||| :..|.. ||   ..:.:..||   .|.::.::          ....:|||.|.:.|.
Human   272 -DANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL----------AGTYICEATNPIGTR 325

  Fly   333 PLRAELNLTVL-YAP-------------------------------------------------- 346
            ..:.|:|:|.. |.|                                                  
Human   326 SGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYS 390

  Fly   347 --KDVYLSGANQAKVGDSVQLSCVTAPSNPQARISWSIN------------GRPLDNSTYKTTSS 397
              |.||.:|.::|.:              ||.....:.|            ..||..|:|:....
Human   391 TKKHVYGNGYSKAGI--------------PQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEE 441

  Fly   398 SDGGW------VSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPS----PPLLT 452
            .:.|.      |...:.....|:: |.:..|..|   |..|:..|..|:...|.|.    ...:.
Human   442 EEEGGGGGERKVGGPHPKYDEDAK-RPYFTVDEA---EARQDGYGDRTLGYQYDPEQLDLAENMV 502

  Fly   453 GYNDGDIL 460
            ..|||..:
Human   503 SQNDGSFI 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbsNP_788355.1 IG_like 45..137 CDD:214653 23/103 (22%)
Ig strand B 56..60 CDD:409353 1/3 (33%)
Ig strand C 68..72 CDD:409353 1/3 (33%)
Ig strand E 91..105 CDD:409353 1/16 (6%)
Ig strand F 115..120 CDD:409353 2/4 (50%)
Ig strand G 128..131 CDD:409353 0/2 (0%)
Ig 162..232 CDD:472250 16/85 (19%)
Ig strand B 162..167 CDD:409353 1/4 (25%)
Ig strand C 177..181 CDD:409353 1/6 (17%)
Ig strand E 207..211 CDD:409353 1/9 (11%)
Ig strand F 221..226 CDD:409353 1/4 (25%)
Ig 246..342 CDD:472250 25/103 (24%)
Ig strand B 269..273 CDD:409353 1/3 (33%)
Ig strand C 283..287 CDD:409353 0/3 (0%)
Ig strand F 320..325 CDD:409353 1/4 (25%)
Ig strand G 335..338 CDD:409353 0/2 (0%)
Ig 343..431 CDD:472250 21/158 (13%)
Ig strand B 363..367 CDD:409353 0/3 (0%)
Ig strand C 377..381 CDD:409353 0/3 (0%)
Ig strand E 406..410 CDD:409353 0/3 (0%)
Ig strand F 420..425 CDD:409353 1/4 (25%)
Ig 443..527 CDD:472250 5/22 (23%)
Ig strand B 466..470 CDD:409353
Ig strand C 480..484 CDD:409353
Ig strand E 503..507 CDD:409353
Ig strand F 517..522 CDD:409353
Ig 554..640 CDD:472250
Ig strand B 561..565 CDD:409353
Ig strand C 575..579 CDD:409353
Ig strand E 602..608 CDD:409353
Ig strand F 618..623 CDD:409353
Ig strand G 633..636 CDD:409353
Ig_3 643..722 CDD:464046
Ig 748..829 CDD:472250
Ig strand B 756..760 CDD:409353
Ig strand C 769..775 CDD:409353
Ig strand E 792..798 CDD:409353
Ig strand F 808..813 CDD:409353
Ig strand G 822..825 CDD:409353
Ig_3 833..918 CDD:464046
FN3 <932..1151 CDD:442628
FN3 935..1017 CDD:238020
NECTIN1NP_002846.3 IgV_1_Nectin-1_like 31..143 CDD:409469 23/104 (22%)
FR1 31..54 CDD:409469 5/9 (56%)
Ig strand A 31..35 CDD:409469
Ig strand A' 37..41 CDD:409469
Ig strand B 46..54 CDD:409469 3/7 (43%)
CDR1 55..62 CDD:409469 1/6 (17%)
FR2 63..69 CDD:409469 2/5 (40%)
Ig strand C 64..69 CDD:409469 2/4 (50%)
CDR2 70..89 CDD:409469 1/18 (6%)
Ig strand C' 79..84 CDD:409469 0/4 (0%)
Ig strand C' 86..90 CDD:409469 2/3 (67%)
FR3 90..128 CDD:409469 8/41 (20%)
Ig strand D 97..101 CDD:409469 1/3 (33%)
Ig strand E 106..113 CDD:409469 0/6 (0%)
Ig strand F 120..128 CDD:409469 2/7 (29%)
CDR3 129..132 CDD:409469 0/2 (0%)
Ig strand G 132..142 CDD:409469 4/11 (36%)
FR4 133..143 CDD:409469 3/11 (27%)
IgC1_2_Nectin-1_like 146..243 CDD:143298 22/120 (18%)
Ig strand A 146..152 CDD:143298 2/6 (33%)
Ig strand B 168..175 CDD:143298 2/6 (33%)
Ig strand C 180..186 CDD:143298 0/5 (0%)
Ig strand C' 188..190 CDD:143298 0/1 (0%)
Ig strand D 191..199 CDD:143298 2/7 (29%)
Ig strand E 205..213 CDD:143298 0/7 (0%)
Ig strand F 223..230 CDD:143298 1/6 (17%)
Ig strand G 234..240 CDD:143298 2/23 (9%)
Ig 247..333 CDD:472250 23/98 (23%)
Ig strand B 265..269 CDD:409353 1/3 (33%)
Ig strand C 279..283 CDD:409353 0/3 (0%)
Interaction with FGFR. /evidence=ECO:0000250|UniProtKB:Q9JKF6 282..299 3/16 (19%)
Ig strand E 298..302 CDD:409353 2/3 (67%)
Ig strand F 313..318 CDD:409353 1/4 (25%)
Ig strand G 330..333 CDD:409353 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..488 19/106 (18%)
Blue background indicates that the domain is not in the aligned region.

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