DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and kirrel3b

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_021323594.1	Gene:	kirrel3b / 572369	ZFINID:	ZDB-GENE-100713-3	Length:	795	Species:	Danio rerio

Alignment Length:	969	Identity:	206/969 - (21%)
Similarity:	340/969 - (35%)	Gaps:	274/969 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQI 105
            |...|.||.::.|....|.|.:....|.|.|.:||.|||....:.|:|||:|:.|.....::|:|
Zfish    31 FSQQPQDLVVVAGQPVTLPCSIPGYHGVVLWLRDGLALGVGRDLSGYPRYAVVGDHGSGEHHLRI 95

  Fly   106 KNATLEDDAEYQCQVGPAAGNPAIRAN-AKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIA 169
            :...|.|||.::||    |...|:|:. |:|:::..|...:|.|   ...|.:.....|.|.|.|
Zfish    96 QKVELMDDAVFECQ----AIQAAMRSRPARLTVLVPPDDPMITG---GPVVSLRAGDPLNLTCHA 153

  Fly   170 ENANPAAEIVWFQ-GEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPP 233
            :||.|||.|:|.: |||........|:.:.. :|.:|.|||::.....:..::..|.|.:||:|.
Zfish   154 DNAKPAASIIWIRNGEVLNGAMYSKTLLRDG-RRESTVSTLYISASNIESGQKIICRASNKAVPN 217

  Fly   234 --------DVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNG 290
                    |:.....|.|||             :.:.:..|..|:..|.::...|..|..|.:.|
Zfish   218 GKETSVTIDIQHLPLVNLSV-------------EPQPVLEGNLVKFHCSAKANPPVTQYKWAKGG 269

  Fly   291 VAISSPQRTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGAN 355
            ..|   :..||...|.:...:...|.    :.||..|.|.:|.:  ..|:.|.:.|:......:.
Zfish   270 SVI---KEVSGDTYEVIVDHSFFTEP----VSCEVTNPLGSTNI--SRNVDVYFGPRMAAEPQSL 325

  Fly   356 QAKVGDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFI 420
            |..:|.....:|... .||...|.|...|              .|..:|:.|| ||:.|
Zfish   326 QVDLGSDAVFNCAWT-GNPSLTIVWMKRG--------------SGVVLSNENI-LTLKS------ 368

  Fly   421 AVCHALNTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYK 485
                     :.|...|.:....:.|.
Zfish   369 ---------VRQEDAGKYVCRAVVPR--------------------------------------- 385

  Fly   486 NDKIINAPSKLVDSKITSELSLLVNASDNNAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISV 550
                :.|..|        |:||.||.                              ||   .||.
Zfish   386 ----VGAAEK--------EVSLTVNG------------------------------PP---TISS 405

  Fly   551 VPKNLVP-GIRAKLICDSSSSNPPAKISW-WKDGIPVEGLN---LANRPGLWGGSVSTLEMYVNI 610
            ...:..| |.:.::.|...|:.||.:|:| ||:.:...|.:   .........|.:|||.|...:
Zfish   406 TQTHQAPHGEKGQIKCFIRSTPPPDRIAWSWKETVLESGTSGRYTVETVSTEDGVLSTLTMSNIV 470

  Fly   611 TQDLDGIVYTCQSHN------EVL----QRSVHETISLDILYPPKFETPQSTTFVGVEGAPFHVE 665
            ..|.. .:|.|.:.|      |::    |....:::.:.::             :||....|...
Zfish   471 PADFQ-TIYNCTAWNSFGSDTEIIRLKEQGGSQDSLPVAVI-------------IGVAVGAFVAF 521

  Fly   666 LLASGNPMVITYT----------WTKDG---LPISSNSLSGQR--LISDGPRLNISRL--SRNDA 713
            ::..|.......|          .|:|.   :|....|:..|:  |.|.....|:..:  ::||.
Zfish   522 IVLMGTIGAFCCTRSQRKKSAHLCTEDAHLVMPTLPTSICAQQRELASKIKTENLKGVVSAKNDI 586

  Fly   714 GVYICEALNSQGTALLEIQVAVEYAPTITAVSEGRSF----VAGEPAVLACHIQARPLEAAHVRW 774
            .|   |.::....|..|.:   |::.....:.|...|    |..:..||    |....|..|::.
Zfish   587 RV---EIVHKDHNAARESE---EHSGMKQLMIERGEFQQESVLKQLEVL----QEEEKEYQHIKD 641

  Fly   775 SRDGYDLATRTISSFE--NGT----ALLQIASVERSDIGNFTCIVDNQRGAPAAQ---NVLLVVQ 830
            ..:||    .::::|:  :||    |..|...:.|...   |.....|| .|...   |:...:.
Zfish   642 PTNGY----YSVNTFKEHHGTPTTMAGNQTTELRRDPA---TATTGKQR-VPTGMSFTNIYSTLG 698

  Fly   831 TAPE--IDHSPGFTRYAARLGVRAQLIC-----RSLASPQPSFIWRRHGKDLKMQRRNKFKSVER 888
            ..|.  .|:|   .|:...:|..:..:|     |...|...||        |..|..:...|..:
Zfish   699 AGPNRLYDYS---QRFVLGMGSSSIELCEREFQRGSMSDSSSF--------LDTQCDSSVSSYSK 752

  Fly   889 QVDALNFESALLIENTSPDDYGQYECVVRNSLGQASTTLEFSKPSRPDA----PLQLRV 943
            |                 |.|.|::   ::|...||::..:|:.|..::    |||.|:
Zfish   753 Q-----------------DGYVQFD---KDSKASASSSSHYSQSSSQNSDLTRPLQKRM 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	28/77 (36%)
		IG_like	45..137	CDD:214653	33/92 (36%)
		Ig	153..231	CDD:299845	24/78 (31%)
		IG_like	258..342	CDD:214653	18/83 (22%)
		Ig	266..327	CDD:299845	14/60 (23%)
		IG_like	357..>414	CDD:214653	13/56 (23%)
		Ig	360..427	CDD:299845	14/66 (21%)
		Ig	<468..526	CDD:299845	7/57 (12%)
		I-set	547..633	CDD:254352	24/100 (24%)
		Ig	556..631	CDD:299845	22/89 (25%)
		I-set	644..735	CDD:254352	19/107 (18%)
		IGc2	668..725	CDD:197706	14/73 (19%)
		IG_like	751..829	CDD:214653	19/86 (22%)
		IGc2	753..815	CDD:197706	14/67 (21%)
		Ig	852..928	CDD:143165	15/80 (19%)
		FN3	935..1017	CDD:238020	4/13 (31%)
kirrel3b	XP_021323594.1	IG_like	35..124	CDD:214653	33/92 (36%)
		Ig2_KIRREL3-like	146..227	CDD:143236	25/81 (31%)
		Ig_2	235..312	CDD:316418	21/98 (21%)
		I-set	316..397	CDD:333254	24/162 (15%)
		Ig5_KIRREL3	399..496	CDD:143306	25/130 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920