DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and kirrel3a

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_700618.5	Gene:	kirrel3a / 571887	ZFINID:	ZDB-GENE-091117-44	Length:	774	Species:	Danio rerio

Alignment Length:	952	Identity:	198/952 - (20%)
Similarity:	338/952 - (35%)	Gaps:	261/952 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQIKNAT 109
            ||||.|:.|....|.|.:....|.|.|.|||.|||.:..:.|:|||.|:.|..:..|:|.|:...
Zfish    27 PHDLVIVAGEPVTLPCTIIGYQGMVLWVKDGLALGVNRDLSGYPRYDVIGDHSKGEYHLLIERTE 91

  Fly   110 LEDDAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIAENANP 174
            |.||..::||....||.   ...|:|:::..|...||.|   ...|.:....:|.|.|.|.||.|
Zfish    92 LVDDGSFECQAIQVAGR---SRPAQLTVLVPPDDPVIIG---APVVSLRAGDSLNLTCHANNAKP 150

  Fly   175 AAEIVWFQ-GEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPP----- 233
            ||.|:|.: |||....|...|:.:.. ||.:|.||||:.....:..::.:|.|.:||.|.
Zfish   151 AASIIWIRNGEVINGAAYTKTLLRDG-KRESTVSTLHISASNIESGQQITCRASNKAAPNGKEAT 214

  Fly   234 ---DVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISS 295
               |:.....|.|||             :.:.:..|..|:..|.::...|.....|.:.|..|:.
Zfish   215 VTIDIQHFPLVNLSV-------------EPQPVLEGNLVKFHCAAKANPPVTHYRWAKGGSMITD 266

  Fly   296 PQRTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVG 360
               .:|...|.:...:...|.    :.||..|.|.:|.:  ..|:.|.:.|:......:.|...|
Zfish   267 ---ATGDTYEVLVDHSFFTEP----VSCEVTNALGSTNI--SRNVDVYFGPRLAAEPQSLQVDRG 322

  Fly   361 DSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHA 425
            .....||... .||...|.|...|.               |.|.|:..:||:.:
Zfish   323 SDAVFSCAWI-GNPSLTIVWMKRGH---------------GVVLSNENTLTLKA----------- 360

  Fly   426 LNTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKII 490
                :.|...|.:....:.|     ..|..:.:::::            .|.||::.
Zfish   361 ----VRQEDAGKYVCRAVVP-----RVGVGEKEVMLT------------VNGPPSIS-------- 396

  Fly   491 NAPSKLVDSKITSELSLLVNASDNNAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNL 555
                               :.....|:|
Zfish   397 -------------------STQTQQALY------------------------------------- 405

  Fly   556 VPGIRAKLICDSSSSNPPAKISW-WKDGIPVEGLN-------LANRPGLWGGSVSTLEMYVNITQ 612
              |.:.::.|...|:.||.:|:| ||:.:...|.:       ::...|:    :|||.|...:..
Zfish   406 --GEKGQIKCFIRSTPPPDRIAWSWKETVLESGTSGRYTVETVSTEEGV----ISTLTMRNIVPT 464

  Fly   613 DLDGIVYTCQSHN------EVLQRSVHETISLDILYPPKFETPQSTTFVGVEGAPF--HVELLAS 669
            |.. .:|.|.:.|      |:::.....::.|.::             :||....|  .:.|:.:
Zfish   465 DFQ-TIYNCTAWNSFGSDTEIIRLKEQGSLRLAVI-------------IGVAVGAFLALIVLIGT 515

  Fly   670 GNPMVITYTWTKD------GLPISSNSLSGQRLISDGPRL-NISRL--SRNDAGVYICEALNSQG 725
            ...........||      .||:|.:  |.||.||...:. |:..:  ::||..|   |.::...
Zfish   516 LGAFCCARLQRKDMHLVMSSLPVSLS--SRQREISGTVKSENLKGVVSAKNDIRV---EIVHKDH 575

  Fly   726 TALLEIQVAVEYAPTITAVSEGRSF----VAGEPAVLACHIQARPLEAAHVRWSRDGYDLATRTI 786
            .|..|.:   |::.....:.|...|    |..:..||    |....|..|::...:||    .::
Zfish   576 NAAREPE---EHSNVKQMMMERADFQQESVLKQLEVL----QEEERELQHIKDPTNGY----YSV 629

  Fly   787 SSF-ENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQ---NVLLVVQTAPE--IDHSPGFTRYA 845
            ::| |..|..:.:.:.:.:::.|.......:...|...   |:...:...|.  .|:|   .|:.
Zfish   630 NTFKEQPTPTISLTANQNAEVRNPATATLGKHRVPTGMSYTNIYNTLGAGPNRLYDYS---QRFV 691

  Fly   846 ARLGVRAQLIC-----RSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTS 905
            ..:|..:..:|     |...|...||      :|  .|..:...|..:|
Zfish   692 LGMGSSSIELCEREFQRGSLSDSSSF------QD--TQCDSSVSSYSKQ---------------- 732

  Fly   906 PDDYGQYECVVRNSLGQASTTLEFSKPSRPDA----PLQLRV 943
             |.|.|::   :.|....|::..:|:.|..::    |||.|:
Zfish   733 -DGYVQFD---KASKASVSSSSHYSQSSSQNSDLTRPLQKRM 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	31/76 (41%)
		IG_like	45..137	CDD:214653	35/91 (38%)
		Ig	153..231	CDD:299845	27/78 (35%)
		IG_like	258..342	CDD:214653	16/83 (19%)
		Ig	266..327	CDD:299845	12/60 (20%)
		IG_like	357..>414	CDD:214653	13/56 (23%)
		Ig	360..427	CDD:299845	13/66 (20%)
		Ig	<468..526	CDD:299845	5/57 (9%)
		I-set	547..633	CDD:254352	20/99 (20%)
		Ig	556..631	CDD:299845	20/88 (23%)
		I-set	644..735	CDD:254352	21/101 (21%)
		IGc2	668..725	CDD:197706	15/65 (23%)
		IG_like	751..829	CDD:214653	14/81 (17%)
		IGc2	753..815	CDD:197706	11/62 (18%)
		Ig	852..928	CDD:143165	14/80 (18%)
		FN3	935..1017	CDD:238020	4/13 (31%)
kirrel3a	XP_700618.5	Ig	25..116	CDD:299845	35/91 (38%)
		IG_like	27..116	CDD:214653	35/91 (38%)
		I-set	123..217	CDD:254352	32/97 (33%)
		Ig2_KIRREL3-like	139..219	CDD:143236	28/80 (35%)
		Ig_2	227..304	CDD:290606	19/98 (19%)
		I-set	308..389	CDD:254352	19/128 (15%)
		IGc2	322..373	CDD:197706	15/81 (19%)
		Ig5_KIRREL3	391..488	CDD:143306	24/167 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920