DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and kirrel3l

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001092814.2	Gene:	kirrel3l / 557315	ZFINID:	ZDB-GENE-070831-1	Length:	755	Species:	Danio rerio

Alignment Length:	1014	Identity:	235/1014 - (23%)
Similarity:	341/1014 - (33%)	Gaps:	341/1014 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQI 105
            |...|.|..::.|....|.|.:....|.|||||||.|||....:||:.|||::.|.....::|.|
Zfish    20 FSQQPQDQVVVAGQSVTLPCVIVGYRGMVQWTKDGLALGGERDLPGWVRYSLMGDPLSGEHSLVI 84

  Fly   106 KNATLEDDAEYQCQVGPAAGNPAIRAN-AKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIA 169
            .:|.|.|||.|:||    |....:|:: |||:::..||..::|| ....|::.....|||  |.|
Zfish    85 DSAELGDDAIYECQ----ATQAGLRSHRAKLTVLVPPSDPIVEG-GPVVRLKAHTPHNLT--CRA 142

  Fly   170 ENANPAAEIVWFQ-GEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPP 233
            ..|.|||||.|:: ||:..:.....::.:.. ||.|..|.|.:.|...|..:.::|...:.|.|
Zfish   143 SGAKPAAEITWYRDGEIMQNAIYSKSLMEDG-KRETAVSMLPMVPEDSDSGRTYTCRVLNPAAP- 205

  Fly   234 DVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLT---WYRNGVAISS 295
             ...:..|.::|.:||....   ..|.:|:..|.:|...| |...||  ::|   |.:.||.||
Zfish   206 -AGRQTSVTINVQHPPSVTL---SVQPQTVMEGAKVLFIC-SASANP--EITGYRWSKGGVPIS- 262

  Fly   296 PQRTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVG 360
                               |.||.:|...|.:...|.|:..|::
Zfish   263 -------------------EANGDSLEVTADHSYFTDPVSCEVS--------------------- 287

  Fly   361 DSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHA 425
                                        ||            |.|:|:|..:|.|
Zfish   288 ----------------------------NS------------VGSTNVSTLVDVQ---------- 302

  Fly   426 LNTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKII 490
                        ....:|..|.|.::      ||   |......||.. ||||.||.|.|..
Zfish   303 ------------FGPRLLTEPKPQIV------DI---GMDAAFTCSWT-GNPPLTLAWTKQG--- 342

  Fly   491 NAPSKLVDSKITSELSLLVNASDNNAIYKCK-----VQNAAIDIPLFATKTLGVHFPPETVKISV 550
               |.:|.|. ::.|.|.....|:...|.||     :..|..|:      ||.|:.||  :..:.
Zfish   343 ---SNVVLSN-SNTLQLKAVTQDDTGTYTCKAIVPRIGVAERDV------TLTVNGPP--IITAE 395

  Fly   551 VPKNLVPGIRAKLICDSSSSNPPAKISWW----------KDGIPVEGLNLANRPGLWGGSVSTLE 605
            ..:..:...:.||.|...||.||.||.|.          .....|:.:|...      |.:|:|.
Zfish   396 ATQQAIKHSKGKLECLVGSSPPPDKIVWTFGDMMLSSGSSGRFSVQTVNSDQ------GVLSSLI 454

  Fly   606 MYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQS-TTFVGVEGAPFHVELLAS 669
            :...:.||.. :.|.|.:.|                   :|.|..: .|....|..|..:.:.||
Zfish   455 LSETLAQDFQ-LRYNCTAWN-------------------RFGTGTALVTLEEQEALPLLIIIGAS 499

  Fly   670 --GNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNI-----SRLSRNDAGVYICEALNSQGTA 727
              |..:.|....|               |:|...|.|.     :|||::|..|.|   ::|...|
Zfish   500 VGGGCVFIVCVIT---------------LVSICCRHNAKGKKGTRLSKSDIRVQI---VHSDHNA 546

  Fly   728 LL----EIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDGYDLATRTISS 788
            ..    |..|....||. ::.|.|.|                                  ||..|
Zfish   547 ARGNDDEEDVKEPMAPN-SSESPGTS----------------------------------RTEHS 576

  Fly   789 FENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDH--SPGFTRYAARLGVR 851
                 .||:....|||||.:.|....|.|              |.|..|  ..||:.||.    .
Zfish   577 -----DLLEEEDDERSDIKDPTNGYYNVR--------------AHEDRHITRTGFSEYAN----N 618

  Fly   852 AQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPD--DYGQ-YE 913
            |:.:......|.||.::.:|                               :|.|.  |:.| |.
Zfish   619 ARPVYTPTQLPSPSPLYGQH-------------------------------STQPRIYDFSQRYA 652

  Fly   914 CVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQTYFRLRLKQHGEDK 978
            ....|     .||.|..:|.:|....|.......:|        .:.|  .||..   ..:|...
Zfish   653 TTPAN-----RTTYEQQQPQQPQQQPQTPTAYPQET--------VYSG--STYLP---ATYGRAF 699

  Fly   979 YKYVDAKPGHQNISLDGLKPGATYYFSVMAANEAGGSKF 1017
            ..||  ||.... .:||      |..|..|:..:..|:|
Zfish   700 TSYV--KPASYE-KVDG------YEHSDQASKVSSSSRF 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	32/77 (42%)
		IG_like	45..137	CDD:214653	37/92 (40%)
		Ig	153..231	CDD:299845	23/78 (29%)
		IG_like	258..342	CDD:214653	22/86 (26%)
		Ig	266..327	CDD:299845	17/63 (27%)
		IG_like	357..>414	CDD:214653	6/56 (11%)
		Ig	360..427	CDD:299845	8/66 (12%)
		Ig	<468..526	CDD:299845	19/62 (31%)
		I-set	547..633	CDD:254352	20/95 (21%)
		Ig	556..631	CDD:299845	20/84 (24%)
		I-set	644..735	CDD:254352	24/102 (24%)
		IGc2	668..725	CDD:197706	16/63 (25%)
		IG_like	751..829	CDD:214653	13/77 (17%)
		IGc2	753..815	CDD:197706	11/61 (18%)
		Ig	852..928	CDD:143165	13/78 (17%)
		FN3	935..1017	CDD:238020	17/81 (21%)
kirrel3l	NP_001092814.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920