DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hbs and SIRPG

DIOPT Version :9

Sequence 1:NP_001286439.1 Gene:hbs / 44129 FlyBaseID:FBgn0029082 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_061026.2 Gene:SIRPG / 55423 HGNCID:15757 Length:387 Species:Homo sapiens


Alignment Length:302 Identity:72/302 - (23%)
Similarity:119/302 - (39%) Gaps:37/302 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 TLHCIAENANPAAEIVWFQGEVP---------VSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDY 219
            ||||...:..|...::||:|..|         ....|.||......||.....::.:......|.
Human    50 TLHCTVTSLLPVGPVLWFRGVGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADV 114

  Fly   220 KEFSCEARHKALPPDVPMRA--QVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNP-P 281
            ..:.|....|..|.:|..::  ..::::...|.||...|.:...|..  ..|...|.|.|.:| .
Human   115 GTYYCVKFRKGSPENVEFKSGPGTEMALG
AKPSAPVVLGPAARTTPE--HTVSFTCESHGFSPRD 177

  Fly   282 AQLTWYRNGVAISSPQRTSGRLSENV-YKFTAAAE------DNGANLVCEAKNL-LATTPLRAEL 338
            ..|.|::||..:|..|.......::| |...:.|.      |..:.::||..:: |...|||...
Human   178 ITLKWFKNGNELSDFQTNVDPTGQSVAYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGTA 242

  Fly   339 NLT-VLYAPKDVYLSGANQAKVGDSVQLSCVTAPSNPQA-RISWSINGRPLDNSTYKT-TSSSDG 400
            ||: .:..|..:.:: ....:||:.|.::|......||: :::||.||......|..| |.:.||
Human   243 NLSEAI
RVPPTLEVT-QQPMRVGNQVNVTCQVRKFYPQSLQLTWSENGNVCQRETASTLTENKDG 306

  Fly   401 --GWVS---------SSNISLTIDSQSRTFIAVCHALNTELT 431
              .|.|         ..::.||...:....:||...|..|:|
Human   307 TYNWTSWFLVNISDQRDDVVLTCQVKHDGQLAVSKRLALEVT 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbsNP_001286439.1 Ig 44..122 CDD:299845
IG_like 45..137 CDD:214653
Ig 153..231 CDD:299845 17/75 (23%)
IG_like 258..342 CDD:214653 24/93 (26%)
Ig 266..327 CDD:299845 17/68 (25%)
IG_like 357..>414 CDD:214653 19/69 (28%)
Ig 360..427 CDD:299845 20/79 (25%)
Ig <468..526 CDD:299845
I-set 547..633 CDD:254352
Ig 556..631 CDD:299845
I-set 644..735 CDD:254352
IGc2 668..725 CDD:197706
IG_like 751..829 CDD:214653
IGc2 753..815 CDD:197706
Ig 852..928 CDD:143165
FN3 935..1017 CDD:238020
SIRPGNP_061026.2 IgV_SIRP 33..143 CDD:319346 19/92 (21%)
IgC_SIRP_domain_2 145..248 CDD:319314 28/104 (27%)
IgC_SIRP_domain_3 250..353 CDD:319334 25/100 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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