DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and Nphs1

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_062332.2	Gene:	Nphs1 / 54631	MGIID:	1859637	Length:	1256	Species:	Mus musculus

Alignment Length:	1221	Identity:	348/1221 - (28%)
Similarity:	560/1221 - (45%)	Gaps:	97/1221 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CHVMAAVTAPTPAAQVAAPPV-----QKFHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFA 77
            ||::..:.|......:|..||     :.|.....:|.::||:...|.|.|......|||.|||..
Mouse    20 CHLIPLLLAGMLTTGLAQSPVPTSAPRGFWALSENLTVVEGSTVKLWCGVRAPGSVVQWAKDGLL 84

  Fly    78 LGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQVGPA-AGNPAIRANAKLSIVAAP 141
            ||.:..||||||||:..|:.:..::|.|:...|.|||||:||||.: .|...:..:..|||:.:|
Mouse    85 LGPNPKIPGFPRYSLEGDSAKGEFHLLIEACDLSDDAEYECQVGRSELGPELVSPSVILSILVSP 149

  Fly   142 SSIVIEGYARNARVEVEERQNLTLHCIAENANPAAEIVWFQGEVPVSTAPIVTVNQTAPKRFTTS 206
            ..:.:...| .:.|.....|...:.|::.:|.||.:|::.||...|..........:..|.|.|.
Mouse   150 KVLQLTPEA-GSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTE 213

  Fly   207 STLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFE--GYSQGETLHRGQEV 269
            :...:.|::.|:.:...||..:.||.  .|::|...:::|:|||.|..:  |.::|. :..|:.:
Mouse   214 AEARVTPQSSDNGQLLVCEGSNPALA--TPIKASFTMNILFPPGPPVIDWPGLNEGH-VRAGENL 275

  Fly   270 QIACRSRGGNPPAQLTWYRNG--VAISSPQRTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATT 332
            ::.|.:|||||||.|.|.:||  |:|:.....:..::.:|...|...||:||.|.|::.|.::..
Mouse   276 ELPCIARGGNPPATLQWLKNGKPVSIAWGTEHAQAVAHSVLVMTVRPEDHGARLSCQSYNSVSAE 340

  Fly   333 PLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSS 397
            .....:.|.|.:.|..|.:.|:.......:|.|.|:|..|.|:..:.|.:.||.|..:.......
Mouse   341 TQERSITLQVTFPPSAVTILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDETVMDG 405

  Fly   398 SDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVV-GSHTVNVLYPPSPPLLTGYNDGDILI 461
            ..||.:|.||::|.:..:.......|.|.:...::... .|.|:||.||.....:.|..:|..:.
Mouse   406 LHGGHISMSNLTLLVKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEGPPEGQSIR 470

  Fly   462 SGSILKLQCSSAGGNPPPTLQWYKNDKIINAPSKLVD-------------SKITSELSLLVNASD 513
            :|:.::|.|.:.||||.|:|.|.|:.:.:|.|.:..:             |..:.||.|::...|
Mouse   471 TGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRRVQLGSVEKSGSTFSRELVLIIGPPD 535

  Fly   514 NNAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISW 578
            |.|.:.||...      |.|:..|.|.|||..:.|......|.||....|.|.|.|||||..:|.
Mouse   536 NLAKFSCKAGQ------LSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSL 594

  Fly   579 WKDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYP 643
            .|:|..::.:....:...:.||.::..:::.::....|...||::|:|.|:.:|.....|::|||
Mouse   595 DKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTCRAHSEALRETVSSFYRLNVLYP 659

  Fly   644 PKFETPQSTTFVGVEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRL 708
            |:|...|......||.....:.:..|.||....:.||..|..:|.......|::|.| .|.:..:
Mouse   660 PEFLGEQVRAVTVVEQGQALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGG-ALQLWNV 723

  Fly   709 SRNDAGVYICEALNSQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVR 773
            :|.|.|.|.....||:|||...:::.|.|||||.|:.:......|....:.|.:.|.|:......
Mouse   724 TRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALKDPTEVNVGGSVDIVCTVDANPILPEMFS 788

  Fly   774 WSRDGYDLATRTISSFE----NGTALLQIASVERSDIGNFTCIVDNQRG-APAAQN-VLLVVQTA 832
            |.|.|.|.....:...|    ..|..|:|...:.|..|.:.|||||  | ||||:. |.|||:.|
Mouse   789 WERLGEDEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDN--GVAPAARGLVRLVVRFA 851

  Fly   833 PEIDHSPGFTRYAAR--LGVRAQLICRSLASPQPSFIWRRHGKDLKMQ--RRNKFKSVERQVDAL 893
            |::||....|:.||.  ....|.|.||:...|...|.|.::|..|.:|  |..:.|..:..|.:
Mouse   852 PQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVHS- 915

  Fly   894 NFESALLIENTS-PDDYGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTP 957
               |.|.|.|.| ..||..::|...|:||...|.::....||||.||.|:|.:||...|.|.|.|
Mouse   916 ---SLLTIANVSAAQDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVSVSPHSVGLEWKP 977

  Fly   958 GFDGGMQTYFRLRLKQHGEDKYKYVDAKPGH-QNISLDGLKPGATYYFSVMAANEAGGSKFM-PD 1020
            |||||:...|::|.:......:.|:|..|.. ...:|.||||...|...::|:|..|.|... ..
Mouse   978 GFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNALGDSGLTDKG 1042

  Fly  1021 IKLTLSKGSQPHSAEYTEK----------DELPNVMIIGITSAAMVLLVLNAALVAWFVIRRQNK 1075
            |:::::......:.|.|::          ..||.:.:  :.:...:||:.||:.|...:.||:.:
Mouse  1043 IQVSITTPGLDQAPEDTDQPLPTEQPPGPPRLPLLPV--LFAVGGLLLLSNASCVGGLLWRRRLR 1105

  Fly  1076 SQSEAEPSNDDVYSKDDS-QSVYKLPITALQADVQKKAAASTYLVENVDIIQSTAYPPKYQESSM 1139
            ..:|......:..|::|. ::.|:    ..|....:...:||.....||        |.|.....
Mouse  1106 RLAEEISEKTEAGSEEDRIRNEYE----ESQWTGDRDTRSSTVSTAEVD--------PHYYSMRD 1158

  Fly  1140 CTPPYPLCNPDFTRTLPNPKRHSQRNSATGMIEGMQMRSKDDHMLISNGLY 1190
            .:|..|          |..:..|.|.:.||:        :|:.|.....||
Mouse  1159 FSPQLP----------PTLEEVSYRQAFTGI--------EDEDMAFPGHLY 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	34/77 (44%)
		IG_like	45..137	CDD:214653	37/92 (40%)
		Ig	153..231	CDD:299845	17/77 (22%)
		IG_like	258..342	CDD:214653	26/85 (31%)
		Ig	266..327	CDD:299845	23/62 (37%)
		IG_like	357..>414	CDD:214653	16/56 (29%)
		Ig	360..427	CDD:299845	18/66 (27%)
		Ig	<468..526	CDD:299845	21/70 (30%)
		I-set	547..633	CDD:254352	23/85 (27%)
		Ig	556..631	CDD:299845	21/74 (28%)
		I-set	644..735	CDD:254352	25/90 (28%)
		IGc2	668..725	CDD:197706	17/56 (30%)
		IG_like	751..829	CDD:214653	26/83 (31%)
		IGc2	753..815	CDD:197706	17/65 (26%)
		Ig	852..928	CDD:143165	25/78 (32%)
		FN3	935..1017	CDD:238020	32/82 (39%)
Nphs1	NP_062332.2	Ig	52..128	CDD:299845	33/75 (44%)
		IG_like	52..127	CDD:214653	32/74 (43%)
		C2-set_2	155..242	CDD:285423	20/89 (22%)
		Ig	254..332	CDD:299845	27/78 (35%)
		IG_like	268..350	CDD:214653	25/82 (30%)
		C2-set_2	358..440	CDD:285423	19/81 (23%)
		Ig	459..544	CDD:299845	23/84 (27%)
		I-set	460..555	CDD:254352	27/100 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..516		4/24 (17%)
		Ig	563..646	CDD:299845	23/82 (28%)
		IG_like	670..750	CDD:214653	22/80 (28%)
		Ig	676..750	CDD:299845	20/74 (27%)
		Ig_3	753..834	CDD:290638	22/80 (28%)
		IG_like	762..848	CDD:214653	26/87 (30%)
		Ig	848..956	CDD:299845	35/111 (32%)
		IG_like	859..949	CDD:214653	28/93 (30%)
		fn3	956..1039	CDD:278470	31/82 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1071		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1143		4/34 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833721
Domainoid	1	1.000	64	1.000	Domainoid score	I10109
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1366
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0005450
OrthoInspector	1	1.000	-	-		otm42390
orthoMCL	1	0.900	-	-		OOG6_107508
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760