DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and mybpc2b

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001013529.2	Gene:	mybpc2b / 541384	ZFINID:	ZDB-GENE-050320-80	Length:	1111	Species:	Danio rerio

Alignment Length:	1243	Identity:	236/1243 - (18%)
Similarity:	376/1243 - (30%)	Gaps:	482/1243 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEY 116
            :|...::..||::...:|:|.::|..:..||      :|  :::|..|...|.|...:|.|||.|
Zfish   235 KGKKIVMSVEVADPNAEVKWLRNGQEIKPSA------KY--IMEADGNIRTLTINKCSLADDAAY 291

  Fly   117 QCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIAENANPAAEIVWF 181
            :|.||                                          |..|..|         .|
Zfish   292 ECVVG------------------------------------------TDKCFTE---------VF 305

  Fly   182 QGEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVL 246
            ..|.|::...::                       |||        |..:
Zfish   306 VKEPPITITKLL-----------------------DDY--------HVVV--------------- 324

  Fly   247 YPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVYKF- 310
                         ||.:    |.:|.....|    |.:.|      :...|:.|....::.|:|
Zfish   325 -------------GERV----EFEIEVSEEG----AHVIW------LFEDQQLSREDKDSKYRFK 362

  Fly   311 -----------TAAAEDNG------------ANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLS 352
                       .|..||||            ..|:.|.|.|   ..|::..:|||..|.:.::..
Zfish   363 KDGKRHCLIIQEATLEDNGMFYVYTNGGQSKGELIVEEKEL---EVLQSIADLTVKSAEQAMFKC 424

  Fly   353 GANQAKV-----GDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTI 412
            ..:..||     .|.|::.       |..||..|..|| :...|.......|.|
Zfish   425 EVSDEKVTGKWFKDGVEVL-------PSDRIKISHIGR-IHRLTIDDVKPGDAG----------- 470

  Fly   413 DSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPP--SPPLLTGYNDGD-------ILISGSILKL 468
               ..||:...:||:.....|.:   .:.:.|.|  .||.:.....|:       |:::|:.|:|
Zfish   471 ---DYTFVPDGYALSISAKLNFL---EIKIDYVPRQDPPKIHLDVSGNMVSQNTIIVVAGNKLRL 529

  Fly   469 QCSSAGGNPPPTLQWYKNDKIINAPSKLVDSKITSELSLLV---NASDNNAIYKCKVQN-AAIDI 529
            ..... |.|.||:.|.::||.:......|..:...:||..:   ...::...|...|.| |..|.
Zfish   530 DVEIT-GEPAPTVCWMRDDKPVTDSEGRVRVENKKDLSCFIIEGAEREDEGNYTITVTNPAGEDK 593

  Fly   530 PLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLNLANRP 594
            .....|.:.|..|||.||.:.|.::     .|.::.|     ||.    :..|.|::|..:..:.
Zfish   594 ANLFIKIVDVPDPPENVKCTGVGED-----TANIVWD-----PPK----FDGGAPLKGYLMERKK 644

  Fly   595 GLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVG--- 656
               .||....::                                      .|:..:|||:..
Zfish   645 ---KGSSRWTKL--------------------------------------NFDVYESTTYEAKRM 668

  Fly   657 VEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICE-- 719
            :||..:.:.:.|            .:|:.||:.||:.:..:...|....::|:.:|.....|.
Zfish   669 IEGILYEMRVFA------------VNGIGISAPSLNSKPFMPIAPTSEPTKLTVDDVTDTTCSLK 721

  Fly   720 --ALNSQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDGYDLA 782
              |....|...|:..: :|:.      .||.|                       .|.....||.
Zfish   722 WLAPEKIGAGGLDGYI-IEFC------KEGES-----------------------EWHPANTDLV 756

  Fly   783 TRTISSFENGTALLQIASVERSDIGNFTCIVDNQRG-APAAQNVLLVVQ--TAPEIDHSPGF--- 841
            .|  .||       .:.::...:..||..:..|..| :|.|    |:.|  |..||...|..
Zfish   757 ER--QSF-------VVRNLPTGEKMNFRVVAVNIAGRSPPA----LLGQPVTVREIMEHPKIRLP 808

  Fly   842 ----TRYAARLGVRAQLICRSLASPQPSFIWRRHGK---DLKMQRRNKFKSVERQVDALNFESAL 899
                |:|..|:|.:..|:......|:|...|.:.|:   :.|:..||.           |.:|.|
Zfish   809 RDLRTKYIRRVGEKINLVIPFQGKPRPIATWLKDGQPVDEKKVGVRNS-----------NVDSIL 862

  Fly   900 LIENTSPDDYGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQ 964
            .|.....|..|:|...::....:.|.|:|.....:|..|:.:.|.:|......|.|.|..|.|
Zfish   863 FIRAAERDHSGKYTLTLKIENMEDSATIEIRIVDKPGPPIGVHVTDVWGFNAALEWKPPKDDG-- 925

  Fly   965 TYFRLRLKQHGEDKYKYVDAKPGHQNISLDGLKPGATYYFSVMAANEAGGSKFMPDIKLTLSKGS 1029
                                     |..:.|                           .|:.|
Zfish   926 -------------------------NCEITG---------------------------YTIQK-- 936

  Fly  1030 QPHSAEYTEKDELPNVMIIGITSAAMVLLVLNAALVAWFVI----RRQNKSQSEAEPSNDDVYSK 1090
                ||...|:                          ||.:    ||.|.:.|:....|:.::
Zfish   937 ----AEKKTKE--------------------------WFTVYEHNRRTNCTVSDLIIGNEYMF-- 969

  Fly  1091 DDSQSVYKLPITALQADVQKKAAASTYLVENVDIIQSTAY---PPKYQESSM-CTPPY--PLCNP 1149
                .||...:..|..|        ..:.:|..||..:..   ||.|:|..| |.|.:  ||.:.
Zfish   970 ----RVYSENLCGLSED--------PCMSKNNAIISKSGLDYKPPPYKEKDMNCAPKFTAPLVDR 1022

  Fly  1150 DFT-----------RTLPNPKRHSQRNSATGMIEGMQMRSKDDHMLISNG-----LYIPSPSPAS 1198
            ..|           |..|.||....:|.   ||.|     .|...|:.|.     |.|..||...
Zfish  1023 AVTIGYSTAISCAVRAFPKPKIIWMKNK---MIIG-----DDPKFLMQNNQGVLTLNIRKPSTFD 1079

  Fly  1199 SLVIKGSY 1206
            |    |.|
Zfish  1080 S----GKY 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	20/69 (29%)
		IG_like	45..137	CDD:214653	21/84 (25%)
		Ig	153..231	CDD:299845	10/77 (13%)
		IG_like	258..342	CDD:214653	22/107 (21%)
		Ig	266..327	CDD:299845	16/84 (19%)
		IG_like	357..>414	CDD:214653	13/61 (21%)
		Ig	360..427	CDD:299845	14/66 (21%)
		Ig	<468..526	CDD:299845	14/61 (23%)
		I-set	547..633	CDD:254352	11/85 (13%)
		Ig	556..631	CDD:299845	9/74 (12%)
		I-set	644..735	CDD:254352	19/97 (20%)
		IGc2	668..725	CDD:197706	11/60 (18%)
		IG_like	751..829	CDD:214653	13/78 (17%)
		IGc2	753..815	CDD:197706	8/61 (13%)
		Ig	852..928	CDD:143165	17/78 (22%)
		FN3	935..1017	CDD:238020	11/81 (14%)
mybpc2b	NP_001013529.2	IG_like	33..128	CDD:214653
		I-set	223..306	CDD:254352	24/129 (19%)
		Ig	224..295	CDD:299845	19/67 (28%)
		IG_like	319..398	CDD:214653	20/128 (16%)
		Ig	420..>473	CDD:143165	13/74 (18%)
		Ig_C5_MyBP-C	515..600	CDD:143302	19/85 (22%)
		IG_like	518..600	CDD:214653	19/82 (23%)
		FN3	604..690	CDD:238020	25/152 (16%)
		FN3	703..795	CDD:238020	24/134 (18%)
		I-set	803..891	CDD:254352	22/98 (22%)
		Ig_Titin_like	822..894	CDD:143225	18/82 (22%)
		FN3	898..981	CDD:238020	26/174 (15%)
		I-set	1013..1102	CDD:254352	22/83 (27%)
		Ig	1032..1097	CDD:143165	18/64 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000