DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and NPHS1

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens

Alignment Length:	1208	Identity:	351/1208 - (29%)
Similarity:	539/1208 - (44%)	Gaps:	101/1208 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AQVAAPP--VQKFHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVL 93
            ||:|.|.  .:.|...|.:|.::||....|||.||.....|||.|||..||....|||||||.:.
Human    22 AQLAIPASVPRGFWALPENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLE 86

  Fly    94 VDAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNP-AIRANAKLSIVAAPSSIVIEGYARNARVEV 157
            .|..:..::|.|:...|.|||||:||||.:...| .:.....|||:..|..:::...| ...|..
Human    87 GDPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEA-GTMVTW 150

  Fly   158 EERQNLTLHCIAENANPAAEIVWFQGEVPVSTAPIVTVNQ-TAPKRFTTSSTLHLQPRAEDDYKE 221
            ...|...::|::.:|.||.:|........:|... ..||: :..|.||..:|..:.||:.|:.:.
Human   151 VAGQEYVVNCVSGDAKPAPDITILLSGQTISDIS-ANVNEGSQQKLFTVEATARVTPRSSDNRQL 214

  Fly   222 FSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFE--GYSQGETLHRGQEVQIACRSRGGNPPAQL 284
            ..|||...||  :.|::|...::||:|||.|..|  |..:|. :..||.:::.|.:|||||.|.|
Human   215 LVCEASSPAL--EAPIKASFTVNVLFPPGPPVIEWPGLDEGH-VRAGQSLELPCVARGGNPLATL 276

  Fly   285 TWYRNGVAISSPQRT--SGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPK 347
            .|.:||..:|:...|  :..::.:|...|...||:||.|.|||.|.::.......:.|.|.:.|.
Human   277 QWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPS 341

  Fly   348 DVYLSGANQAKVGDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTI 412
            .:.:.|:.......:|.||||:..|.|:..:.|.:..|.|............||.:|.||::...
Human   342 AIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLA 406

  Fly   413 DSQSRTFIAVCHALNTELTQNVV-GSHTVNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGN 476
            ..:.......|.|.:...|:... .|..:||.||.....:.|..:|..|.:|:.::|.|.:.|||
Human   407 RREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGN 471

  Fly   477 PPPTLQWYKNDKIINAPSKLVD--------------SKITSELSLLVNASDNNAIYKCKVQNAAI 527
            |.|:|.|||:.:.: ..|:|..              |..:.||.|:...|||.|.:.||...
Human   472 PEPSLMWYKDSRTV-TESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQ--- 532

  Fly   528 DIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLNLAN 592
               |.|:..|.|.|||..|.|......|.||....|.|.|.|||||..:||.|:|..:||:....
Human   533 ---LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPP 594

  Fly   593 RPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVGV 657
            |...:.||.:...:.:.::....|...||::|:..|:.:|.....|::||.|:|...|......|
Human   595 RRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAV 659

  Fly   658 EGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALN 722
            |.....:.:..|.||....:.||..|..:|.......|::|.| .|::..::|.|.|:|.....|
Human   660 EQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSG-ALHLWNVTRADDGLYQLHCQN 723

  Fly   723 SQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDGYDLATRTIS 787
            |:|||...:::.|.|||||.|:.:......|....:.|.:.|.|:......|.|.|.|...:::.
Human   724 SEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLD 788

  Fly   788 SFE----NGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGFTRYAAR- 847
            ..|    ..|..|:|...:.:..|.:.|||||....||.:.:.|||:.||:::|....|:.||.
Human   789 DMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAG 853

  Fly   848 -LGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTS-PDDYG 910
             ....|.|.||:...|...|.|.::|..|.:|.....:....|...  ..|.|.|.|.| ..||.
Human   854 DSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGV--HSSLLTIANVSAAQDYA 916

  Fly   911 QYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQTYFRLRLKQHG 975
            .:.|...|:||...|.::....||||.|..|:|.:::...|.|.|.||||||:...|.:|.:..|
Human   917 LFTCTATNALGSDQTNIQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALG 981

  Fly   976 EDKYKYVDAKPGH-QNISLDGLKPGATYYFSVMAANEAGGSKFMPDIKLTLSKGSQ-----P--H 1032
            ...:.|||..|.. ...:|.||:|...|...::|:|..|.|..       ..||:|     |  |
Human   982 TPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGL-------ADKGTQLPITTPGLH 1039

  Fly  1033 SAEYTEKDELPNVMIIGITSAAM---------VLLVLNAALVAWFVIRRQNKSQSEAEPSNDDVY 1088
            ......:|:||.....|.:...:         :||:.||:.|...:.:|:.:..:|......:..
Human  1040 QPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGISEKTEAG 1104

  Fly  1089 SKDDS-QSVYKLPITALQADVQKKAAASTYLVENVDIIQSTAYPPKYQESSMCTPPYPLCNPDFT 1152
            |::|. ::.|:......:.|.|    :||        :.:|...|.|:.....:|..|
Human  1105 SEEDRVRNEYEESQWTGERDTQ----SST--------VSTTEAEPYYRSLRDFSPQLP------- 1150

  Fly  1153 RTLPNPKRHSQRNSATGMIEGMQMRSKDDHMLISNGLY 1190
               |..:..|.....||         :|:.|.....||
Human  1151 ---PTQEEVSYSRGFTG---------EDEDMAFPGHLY 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	36/77 (47%)
		IG_like	45..137	CDD:214653	39/92 (42%)
		Ig	153..231	CDD:299845	20/78 (26%)
		IG_like	258..342	CDD:214653	28/85 (33%)
		Ig	266..327	CDD:299845	25/62 (40%)
		IG_like	357..>414	CDD:214653	15/56 (27%)
		Ig	360..427	CDD:299845	17/66 (26%)
		Ig	<468..526	CDD:299845	23/71 (32%)
		I-set	547..633	CDD:254352	26/85 (31%)
		Ig	556..631	CDD:299845	24/74 (32%)
		I-set	644..735	CDD:254352	25/90 (28%)
		IGc2	668..725	CDD:197706	17/56 (30%)
		IG_like	751..829	CDD:214653	21/81 (26%)
		IGc2	753..815	CDD:197706	16/65 (25%)
		Ig	852..928	CDD:143165	23/76 (30%)
		FN3	935..1017	CDD:238020	30/82 (37%)
NPHS1	NP_004637.1	V-set	38..119	CDD:284989	37/80 (46%)
		IG_like	38..113	CDD:214653	34/74 (46%)
		C2-set_2	141..228	CDD:285423	23/90 (26%)
		Ig	240..321	CDD:299845	31/81 (38%)
		IG_like	254..336	CDD:214653	27/82 (33%)
		Ig	345..424	CDD:299845	18/78 (23%)
		Ig	445..530	CDD:299845	26/85 (31%)
		I-set	446..541	CDD:254352	30/101 (30%)
		Ig	549..632	CDD:299845	26/82 (32%)
		IG_like	558..642	CDD:214653	26/83 (31%)
		I-set	646..736	CDD:254352	25/90 (28%)
		Ig	662..736	CDD:299845	20/74 (27%)
		Ig_3	739..820	CDD:290638	21/80 (26%)
		IG_like	748..821	CDD:214653	17/72 (24%)
		Ig8_hNephrin_like	834..942	CDD:143250	32/109 (29%)
		IG_like	845..935	CDD:214653	26/91 (29%)
		fn3	942..1023	CDD:278470	28/80 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		8/49 (16%)
		Binds to NPHS2	1160..1241		6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8349
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1398
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0005450
OrthoInspector	1	1.000	-	-		otm40325
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.930