DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and MYBPC1

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_006719468.1	Gene:	MYBPC1 / 4604	HGNCID:	7549	Length:	1195	Species:	Homo sapiens

Alignment Length:	1272	Identity:	237/1272 - (18%)
Similarity:	406/1272 - (31%)	Gaps:	408/1272 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KFHLTPHDLQILEGTDTLLRCEVSN---RAGKVQWTKDGFALGFSAVI-----------PGFPRY 90
            ||.....||::.|.|.|....::.:   |:|:.|  :|...|.||.::           |....:
Human   174 KFDSCSFDLEVHESTGTTPNIDIRSAFKRSGEGQ--EDAGELDFSGLLKRREVKQQEEEPQVDVW 236

  Fly    91 SVLVDAKQNAYNLQIKNATLEDDAEYQCQVGPAAGN----PAIRANAKLSIVAAPSSIVIEGYA- 150
            .:|.:||.:.|          :...:|..:....|.    ..:|...|.|  ||.:.|:...|.
Human   237 ELLKNAKPSEY----------EKIAFQYGITDLRGMLKRLKRMRREEKKS--AAFAKILDPAYQV 289

  Fly   151 -RNARVEVEERQNLTLHCIAENANPAAEIVWFQG--EVPVST---------APIVTVNQTAPKRF 203
             :..||..          :.|.|:|..|:.|::.  |:..||         ..|:.:|..   :.
Human   290 DKGGRVRF----------VVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNC---QM 341

  Fly   204 TTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQE 268
            |..|..::  .|.|:    .|........|.:.:..|:                 :..|.:.|:.
Human   342 TDDSEYYV--TAGDE----KCSTELFVREPPIMVTKQL-----------------EDTTAYCGER 383

  Fly   269 VQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTP 333
            |::.|..  ....|.:.|::||..|....::..|:.....|.....|  ||.....|:..:.||.
Human   384 VELECEV--SEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIE--GATKADAAEYSVMTTG 444

  Fly   334 LRAELNLTVLYAPKDVYLSGANQ-AKVGDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSS 397
            .::...|:|...|..:.....:| ..:|..:.|.|..:.:.|.   .|:.||.|:..|.
Human   445 GQSSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEISENIPG---KWTKNGLPVQESD------ 500

  Fly   398 SDGGWVSSSNISLTIDSQSRTF-IAVCHALNTELTQNVVGSHTVNVLYPP-----SPP--LLTGY 454
                       .|.:..:.|.. :.:.:||..:....|......||..|.     .||  :|.|.
Human   501 -----------RLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGL 554

  Fly   455 NDGD---ILISGSILKLQCSSAGGNPPPTLQWYKNDKIINAPSKLVDSKITSELSLLV---NASD 513
             |.|   .:|:|:.|:|:. ...|.|||...|.:.||.|...|..:.::...:.|.||   ...|
Human   555 -DADNTVTVIAGNKLRLEI-PISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERD 617

  Fly   514 NNAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDS---SSSNPPAK 575
            ::.:|...::|.|.:... :.|...|.||...|..:|..           :.|.   .:..|||
Human   618 DSGVYHINLKNEAGEAHA-SIKVKVVDFPDPPVAPTVTE-----------VGDDWCIMNWEPPA- 669

  Fly   576 ISWWKDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDI 640
               :..|.|:.|..:..:.     ..|:..|.:|
Human   670 ---YDGGSPILGYFIERKK-----KQSSRWMRLN------------------------------- 695

  Fly   641 LYPPKFETPQSTTFVG---VEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPR 702
                 |:..:.|||..   :||..:.|.:.|            .:.:.||..|:..:
Human   696 -----FDLCKETTFEPKKMIEGVAYEVRIFA------------VNAIGISKPSMPSR-------- 735

  Fly   703 LNISRLSRNDAGVYICEALNSQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPL 767
                        .::..|:.|..|.|           |:.:|::....:...|   ..||.|..|
Human   736 ------------PFVPLAVTSPPTLL-----------TVDSVTDTTVTMRWRP---PDHIGAAGL 774

  Fly   768 EAAHVRWSRDGYDL------ATRTISSFENGTALLQ-------IASVERSDIGNFTCIVDNQRGA 819
                     |||.|      :|....|.|||.|...       :|:.:..|...||.     .|.
Human   775 ---------DGYVLEYCFEGSTSAKQSDENGEAAYDLPAEDWIVANKDLIDKTKFTI-----TGL 825

  Fly   820 PAAQNVLLVVQ-------TAPEIDHSPGFTR-----------------YAARLGVRAQLICRSLA 860
            |....:.:.|:       :.|:....|...:                 |..|:|....|:.....
Human   826 PTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQG 890

  Fly   861 SPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFE--SALLIENTSPDDYGQYECVVRNSLGQA 923
            .|:|...|::.|.::.          :.|::..|.|  :.:.|........|:|:..|:......
Human   891 KPRPELTWKKDGAEID----------KNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVE 945

  Fly   924 STTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQTYFRLRLKQHGEDKYKYVDAKPGH 988
            :.:::.....||..|..:::.:|....|.|.|||..|.|........:::..:...::......:
Human   946 TASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHY 1010

  Fly   989 QNIS--LDGLKPGATYYFSVMAANEAGGSKFMPDIKLTLSKGSQPHSAEYTEKDELPNVMIIGIT 1051
            ...|  :..|..|..|||.|.:.|..|.|:     ..|::|.|.
Human  1011 HRTSATITELVIGNEYYFRVFSENMCGLSE-----DATMTKESA--------------------- 1049

  Fly  1052 SAAMVLLVLNAALVAWFVIRRQNKSQSEAEPSNDDVYSKDDSQSVYKLPITALQADVQKKAAAST 1116
                             ||.|..|                    :||.|:
Human  1050 -----------------VIARDGK--------------------IYKNPV--------------- 1062

  Fly  1117 YLVENVDIIQSTAYPPKYQESSMCTPP----YPLCNPDFT-----RTLPNPKRHSQRNSATGMIE 1172
              .|:.|          :.|:.|.|.|    |.:...:.|     |..|.||....:|. ..:::
Human  1063 --YEDFD----------FSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNK-VAIVD 1114

  Fly  1173 GMQMRSKDDHMLISNG---LYIPSPSPASSLVIKGSY 1206
            ..:.|     |..:.|   |.|..|||...    |:|
Human  1115 DPRYR-----MFSNQGVCTLEIRKPSPYDG----GTY 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	18/91 (20%)
		IG_like	45..137	CDD:214653	21/109 (19%)
		Ig	153..231	CDD:299845	17/88 (19%)
		IG_like	258..342	CDD:214653	18/83 (22%)
		Ig	266..327	CDD:299845	14/60 (23%)
		IG_like	357..>414	CDD:214653	10/56 (18%)
		Ig	360..427	CDD:299845	12/67 (18%)
		Ig	<468..526	CDD:299845	16/60 (27%)
		I-set	547..633	CDD:254352	11/88 (13%)
		Ig	556..631	CDD:299845	10/77 (13%)
		I-set	644..735	CDD:254352	15/93 (16%)
		IGc2	668..725	CDD:197706	6/56 (11%)
		IG_like	751..829	CDD:214653	21/90 (23%)
		IGc2	753..815	CDD:197706	19/74 (26%)
		Ig	852..928	CDD:143165	12/77 (16%)
		FN3	935..1017	CDD:238020	20/83 (24%)
MYBPC1	XP_006719468.1	IG_like	89..184	CDD:214653	4/9 (44%)
		Ig	89..173	CDD:299845
		I-set	279..362	CDD:254352	19/101 (19%)
		Ig	304..363	CDD:299845	13/67 (19%)
		I-set	369..453	CDD:254352	19/104 (18%)
		IGc2	381..439	CDD:197706	14/61 (23%)
		IG_like	466..543	CDD:214653	18/96 (19%)
		Ig_C5_MyBP-C	556..641	CDD:143302	22/86 (26%)
		IG_like	559..641	CDD:214653	21/83 (25%)
		FN3	645..735	CDD:238020	24/157 (15%)
		FN3	744..846	CDD:238020	27/129 (21%)
		IG_like	872..953	CDD:214653	15/90 (17%)
		Ig	882..953	CDD:299845	12/80 (15%)
		FN3	957..1040	CDD:238020	19/82 (23%)
		I-set	1072..1161	CDD:254352	20/81 (25%)
		Ig	1089..1154	CDD:143165	16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000