DRSC/TRiP Functional Genomics Resources

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Protein Alignment hbs and LOC4397681

DIOPT Version :10

Sequence 1:NP_788355.1 Gene:hbs / 44129 FlyBaseID:FBgn0287864 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_061513195.1 Gene:LOC4397681 / 4397681 VectorBaseID:AGAMI1_007390 Length:1403 Species:Anopheles gambiae


Alignment Length:1256 Identity:565/1256 - (44%)
Similarity:774/1256 - (61%) Gaps:123/1256 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 QKFHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNL 103
            |||.|.|.||.:.||.:.|||||:.|.||.||||||||||||:..|||:||||||.|:.|..|||
Mosquito    31 QKFRLIPGDLVVSEGAEALLRCEIHNAAGSVQWTKDGFALGFTQSIPGYPRYSVLGDSGQGIYNL 95

  Fly   104 QIKNATLEDDAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCI 168
            :|.|.||||||||||||||...:..|||.|:|:::|.|:||.|:||:::|:|||.|.:.|||.|:
Mosquito    96 RIVNVTLEDDAEYQCQVGPYMHHKLIRAKARLTVIAPPTSIQIQGYSQHAKVEVREGEELTLTCV 160

  Fly   169 AENANPAAEIVWFQGEVPVSTAPIVTVN-QTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALP 232
            ..||.|||:|||::..|...:..|.|.: :|...|:|.:|.|.|||.|||||.:::|:|||:|:|
Mosquito   161 VPNARPAAQIVWYRANVEYKSNTIETKSAETEDHRYTATSKLQLQPTAEDDYIDYTCQARHQAIP 225

  Fly   233 PDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQ 297
            .|.||::.||||||||||.|:.|||:.||.:.|||.||:|||||||||||||.||:||.......
Mosquito   226 EDRPMQSTVQLSVLYPPGVPYIEGYAPGEVIRRGQHVQLACRSRGGNPPAQLIWYKNGNQARMAY 290

  Fly   298 RTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDS 362
            ||:.|.|||:|.|.|.|.||.|.|.|||.|.:||..|:||:.|.||:||..|.:||.::|:||||
Mosquito   291 RTTDRFSENIYAFVAEASDNKARLRCEANNKMATKILKAEIILNVLFAPTQVIVSGPSEARVGDS 355

  Fly   363 VQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALN 427
            |.|.|.|..|||.|.|.|.:||:.:.|::.|...|.:||||::|||:.|:::..|:.:|:||.:|
Mosquito   356 VALQCQTTASNPAAEIKWVVNGKQVTNASSKVVPSPEGGWVTTSNITATVEASKRSLVAICHGVN 420

  Fly   428 TELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKIINA 492
            .:|.:||..:||||||.||.||:::||.:|.|:..|:..|:.|:|:||||..||.||||||.|.:
Mosquito   421 MQLPENVQSTHTVNVLLPPGPPIISGYTEGSIITVGTRQKIMCTSSGGNPLATLVWYKNDKKIKS 485

  Fly   493 PSKLVDSKITSELSLLVNASDNNAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVP 557
            .||..|..:::|||:|.|.:||.|.|:|:..|:|.:||||.||.|.|||.|||.||.:.|..|.|
Mosquito   486 VSKTTDQSVSAELSMLANVTDNQAQYRCEAHNSATEIPLFETKVLTVHFAPETAKIRIEPAELRP 550

  Fly   558 GIRAKLICDSSSSNPPAKISWWKDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQ 622
            ||.|.|||||||||||||:||..:|..:||.|.:::.|||||:||:||:.:|||||:||.|||||
Mosquito   551 GIEATLICDSSSSNPPAKLSWRHEGTVLEGTNNSSKAGLWGGTVSSLELKLNITQDMDGHVYTCQ 615

  Fly   623 SHNEVLQRSVHETISLDILYPPKFETPQSTTFVGVEGAPFHVELLASGNPMVITYTWTKDGLPIS 687
            |.||:||||::..::|.:||.|:|:||..|...||.|.|..|.|:|:|||..|.|||||:|..|:
Mosquito   616 STNEMLQRSINVAVNLPVLYEPRFQTPAETVVHGVAGEPLTVALVATGNPSSIAYTWTKNGQTIA 680

  Fly   688 SNSLSGQ-RLISDGPRLNISRLSRNDAGVYICEALNSQGTALLEIQVAVEYAPTITAVSEGRSFV 751
            |...||: |::|:||.|||::|.|.|||||.|||:||||:|::.|.:.|:||.||.|:||..:..
Mosquito   681 STGSSGEPRIVSEGPILNITKLERTDAGVYTCEAVNSQGSAMINITLQVKYAATIKAISEHVTVD 745

  Fly   752 AGEPAVLACHIQARPLEAAHVRWSRDGYDLATRTISSFENGTALLQIASVERSDIGNFTCIVDNQ 816
            .||.|:|.|.:...||...|:||.||||||..:|.:.:.|||..|.:...:|.|:|||.||.||:
Mosquito   746 PGEDAILNCTVDGNPLTPDHIRWERDGYDLRAKTTTGYANGTGTLVVKDAQREDVGNFRCIADNR 810

  Fly   817 RGAPAAQNVLLVVQTAPEIDHSPGFTRYAARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRN 881
            ..||.::||||:|:.|||||.||...|.|:..|.:|:|.||:.|:|.|.|.|.|.|::|.:.:.:
Mosquito   811 VAAPESRNVLLIVKFAPEIDKSPAMLRAASGPGDQARLPCRAKAAPAPIFHWIRTGQELPINQSS 875

  Fly   882 KFKSVERQVDALNFESALLIENTSPDDYGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNV 946
            |:.:::||:|.|..||.|:||..|..|||.|||..:|.||..|.|......|.||:|..|.|.||
Mosquito   876 KYYTLQRQLDPLTHESILVIERISSRDYGDYECRAKNELGSGSGTGRLDVRSAPDSPATLTVLNV 940

  Fly   947 SDTGVDLNWTPGFDGGMQTYFRLRLKQHGEDKYKYVDAKPGHQNISLDGLKPGATYYFSVMAANE 1011
            :...|.|.|.||||||.:..:|:|.::...::|:|.|..|....:::.||:....|.||:||||.
Mosquito   941 THDSVTLGWEPGFDGGHRASYRIRYREATSERYRYEDGPPNAHQLTVAGLRSNTLYLFSIMAANV 1005

  Fly  1012 AGGSKFMPDIKLTLSKGSQPHSAEYTEKDELPN-------VMIIGI-TSAAMVLLVLNAALVAWF 1068
            .|.|:::||:....:|..||.....:.....|:       :|::|| .:|.:.|::||..|:.:.
Mosquito  1006 LGESRYLPDLTRAQTKERQPQPPMESSSFLAPSSPAGPSTLMLLGIGVAAGIALVLLNILLIGFC 1070

  Fly  1069 VIRRQNKSQSEAE--------------------------------PS--ND-------------- 1085
            :.||.....|.:.                                ||  ||              
Mosquito  1071 LYRRSLPGSSSSRRARHDHKYTGALYNSGDSSNPNSKSATIEMYAPSSYNDTVTGETLSSVSEKS 1135

  Fly  1086 DVYSKDDSQSVYKLPITALQADVQKKAAASTYLVENVDIIQSTAYPPKYQESSMCTPPYPLCNPD 1150
            |.||.|.||..:        .|..:|.|.||||::..::     .||:||:..            
Mosquito  1136 DAYSNDGSQPDF--------MDETRKRAVSTYLIDGGEM-----QPPRYQQEG------------ 1175

  Fly  1151 FTRTLPNPKRHSQRNSATGMIEGMQMRSKDDHMLISNGLYIPSPSPASSLVIKGSYISSPSPAPP 1215
               .||    |...|:.|                 .||.....|:..    :|.|.:        
Mosquito  1176 ---NLP----HYASNTGT-----------------ENGYDQSGPTDQ----LKNSTM-------- 1204

  Fly  1216 ADGSYFNM-SDKYMSYPPVTY 1235
             ||||::| :|::  |||:.|
Mosquito  1205 -DGSYYHMNNDRF--YPPMDY 1222

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbsNP_788355.1 IG_like 45..137 CDD:214653 60/91 (66%)
Ig strand B 56..60 CDD:409353 2/3 (67%)
Ig strand C 68..72 CDD:409353 2/3 (67%)
Ig strand E 91..105 CDD:409353 8/13 (62%)
Ig strand F 115..120 CDD:409353 4/4 (100%)
Ig strand G 128..131 CDD:409353 1/2 (50%)
Ig 162..232 CDD:472250 33/70 (47%)
Ig strand B 162..167 CDD:409353 3/4 (75%)
Ig strand C 177..181 CDD:409353 2/3 (67%)
Ig strand E 207..211 CDD:409353 2/3 (67%)
Ig strand F 221..226 CDD:409353 1/4 (25%)
Ig 246..342 CDD:472250 57/95 (60%)
Ig strand B 269..273 CDD:409353 2/3 (67%)
Ig strand C 283..287 CDD:409353 2/3 (67%)
Ig strand F 320..325 CDD:409353 2/4 (50%)
Ig strand G 335..338 CDD:409353 1/2 (50%)
Ig 343..431 CDD:472250 39/87 (45%)
Ig strand B 363..367 CDD:409353 2/3 (67%)
Ig strand C 377..381 CDD:409353 1/3 (33%)
Ig strand E 406..410 CDD:409353 3/3 (100%)
Ig strand F 420..425 CDD:409353 2/4 (50%)
Ig 443..527 CDD:472250 40/83 (48%)
Ig strand B 466..470 CDD:409353 1/3 (33%)
Ig strand C 480..484 CDD:409353 2/3 (67%)
Ig strand E 503..507 CDD:409353 2/3 (67%)
Ig strand F 517..522 CDD:409353 2/4 (50%)
Ig 554..640 CDD:472250 53/85 (62%)
Ig strand B 561..565 CDD:409353 2/3 (67%)
Ig strand C 575..579 CDD:409353 2/3 (67%)
Ig strand E 602..608 CDD:409353 3/5 (60%)
Ig strand F 618..623 CDD:409353 4/4 (100%)
Ig strand G 633..636 CDD:409353 0/2 (0%)
Ig_3 643..722 CDD:464046 43/79 (54%)
Ig 748..829 CDD:472250 36/80 (45%)
Ig strand B 756..760 CDD:409353 2/3 (67%)
Ig strand C 769..775 CDD:409353 2/5 (40%)
Ig strand E 792..798 CDD:409353 3/5 (60%)
Ig strand F 808..813 CDD:409353 3/4 (75%)
Ig strand G 822..825 CDD:409353 0/2 (0%)
Ig_3 833..918 CDD:464046 38/84 (45%)
FN3 <932..1151 CDD:442628 72/274 (26%)
FN3 935..1017 CDD:238020 33/81 (41%)
LOC4397681XP_061513195.1 None

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