DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and nrm

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster

Alignment Length:	1459	Identity:	313/1459 - (21%)
Similarity:	515/1459 - (35%)	Gaps:	413/1459 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TFAVHLATTICHVMAAVTAPTPAAQVAAPPVQKFHLTPHDLQILEGTDTLLRCEV-SNRAGK--- 68
            :.::.|...:|  :|.|.:.|  |||.....|:           |....:|.|.| :.:.||
  Fly    24 SISLSLVLVLC--LALVDSST--AQVDTTISQQ-----------ESQSVVLPCPVDAEKCGKLHS 73

  Fly    69 VQWTK--DGFA---LGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQ----VGPAA 124
            :.|.|  |..|   ||.|.|......:...|..:||.|.|.||:..:.|:..|.|.    :....
  Fly    74 LNWFKGDDRIAAMLLGDSNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEET 138

  Fly   125 GNPAIRANAKLSIVAAPSSIVIEGYARNARVE-------VEERQNLTLHCIAENANPAAEIVWFQ 182
            .:.......:|.::..|:.:||.. |:..|::       ::|||:|...|...|..|..|:.||:
  Fly   139 CDNFNGYRIELRVLVPPTEVVILD-AKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFR 202

  Fly   183 GEVPVSTAPIVTVNQTAPKRFTT------------SSTLHLQ--PRAEDDYKEFSCEARHKALPP 233
            |                .||.||            :|||.|.  ...||..::..|..:..|:..
  Fly   203 G----------------TKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQN 251

  Fly   234 DVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQR 298
            ....:..|.|.|  .|.:....|......  :|.:|.:.|...|..|...||||.....|||.:.
  Fly   252 VTVTKFSVDLQV--RPTSIDINGVKHHTV--QGSKVVLTCDIHGARPAVNLTWYNTTTIISSGEN 312

  Fly   299 --TSGRLSENVYK------------FTAAAEDNGANLVCEAKNLL----ATTPLRAELNLTVLYA 345
              |..| |:::.|            |.|...:|.....|||:|::    ...|:.:.|.|.|||.
  Fly   313 EITEVR-SKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYP 376

  Fly   346 PKDVYLSGANQAKVGDSVQLSCVTAPSNPQA--RISW-------SINGRPLDNSTYKTTSSSDGG 401
            |.......|..|...:.|.|:|... :||.:  ::.|       ::|    |.:.||      ||
  Fly   377 PVVKVSPSAITANTSEIVLLNCEYF-ANPASLTQVEWYRNDILVNVN----DTTHYK------GG 430

  Fly   402 WVSSSNISLTIDSQSRTFIA--VCHALNT--------ELTQNVVGSHTVNVLYPPSPPLLTGYND 456
              :|.|::|.|.|..:..|.  .|...|.        ::..:|..:.||.:|..|..|:    .:
  Fly   431 --NSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPV----KE 489

  Fly   457 GDILISGSILKLQCSSAGGNPP--PTLQWYKNDKIINAPSKLVDSKITSE-------LSLLVNAS 512
            .|    .|.:.|.|:....||.  ..::||.|..::   .:|.|.:.|.|       ..||:.:.
  Fly   490 SD----ESNVTLFCNVLDANPSVLTKVRWYANSTLL---KELPDCEETREDLCHIDPSKLLLESI 547

  Fly   513 DNNAI--YKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPA- 574
            .....  |.|:..|||...|....|.|.||:.|....:|..|   :..::.|.:..|.|.:.|.
  Fly   548 GRGFFYNYSCEGFNAAGWGPRSEDKELLVHYEPGPAALSHFP---LVAVKKKSVTFSCSVDDPGF 609

  Fly   575 ----KISWWKDGI-PVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHE 634
                :..|.:.|. |::.:...:    |......|:...|         |:|.::||. .:.|..
  Fly   610 PESNRFRWLRGGRGPLQDIVTKD----WTVEPVGLDSRTN---------YSCYAYNEG-GKGVMA 660

  Fly   635 TISLDILYPPKFETPQSTTFVGVEGAPFHVELLASGNPMVIT----------YTWTKDGLPISSN 689
            |::|::..||.|          ::..|.:..:|.|.....:|          .:|.|||:||..|
  Fly   661 TVNLEVHAPPFF----------IKNLPPYTGILHSSPNATLTCRIECVPRCDISWQKDGVPIERN 715

  Fly   690 S---LSGQRLISDGP----------------------RLNISRLSRNDAGVYICEALNS--QGTA 727
            .   ...::.:...|                      :.||...:.|    |.|.:..:  .|:.
  Fly   716 DSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWPDSKFNIEADNAN----YSCVSTGNIVGGSI 776

  Fly   728 LLEIQVAVEYAPTITAVSEGRSFVAGE--PAVLACHIQARPLEAAHVRWSRDGYDLATRTISSFE 790
            .......:||||..|.|||...:|..:  |..:.|..:|.| |.:: :|.     ....||:
  Fly   777 RSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSRANP-EPSY-KWI-----FKNETIA--- 831

  Fly   791 NGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAP--EIDHSPGFTRYAARLGVRAQ 853
            ||.||:...::.|:|.|.:||:..|:.|:..|:.| :.||..|  ||:..        .:..:..
  Fly   832 NGNALIINTAMNRNDDGTYTCLAYNKHGSSIAKTV-IKVQFKPRCEIERQ--------EIDDQDT 887

  Fly   854 LICRSLASP-QPSFIW---RRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYEC 914
            |||.:..:| :..|.|   ..:..|..:....|..|||:....|..:.|  |..|       |.|
  Fly   888 LICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQTDYA--ISRT-------YRC 943

  Fly   915 VVRNSLGQAS-TTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQTYF----------R 968
            |..|::|... ..:|.::        ||....:.:....:.......|.:.|..          |
  Fly   944 VANNTVGYGPFCEIEVAE--------QLAWWQLWEKNTLIILVAAILGLLLTVIVICCIIICICR 1000

  Fly   969 LRLKQHGEDKY--------------KYVDAKPGHQNISLDG------------------------ 995
            .|.:|   |||              ..:|.....:|:|...
  Fly  1001 RRRRQ---DKYLTEVPINSIQSALSDQLDMSRAGRNLSTQDKCTAILPNPSSSRFIGSAPKSPPR 1062

  Fly   996 --LKPGATYYFS------------VMAANEAGGSKFMPDIKLTLS---KGSQPHS--------AE 1035
              ::||...:.|            .:..|.:|....|..:...||   .||:.:|        :.
  Fly  1063 WPIRPGVMLHVSSNTKENLTVNRMTVKPNVSGNRGDMSQLSAQLSAALNGSRDNSDGTILTEISA 1127

  Fly  1036 YTEKDELPNVMIIGITS---AAMVLLVLNAALVAWFVIRRQNKSQSEAEPSNDDVYS-----KDD 1092
            .:.::|..|:.|:.:|:   |.:...:.|.:.....:|  .:|:.|....:.|.|:|     .||
  Fly  1128 VSGENEASNLSILEVTNRKKATVPSTIRNVSTAEGEII--SSKTHSAGHIALDHVWSLIFKKSDD 1190

  Fly  1093 S----------------------------QSVYKLPITALQADVQKKAAASTYLVENVDIIQSTA 1129
            .                            :|.::|........|..|.|..|        :.||:
  Fly  1191 RTRDSQRSHVGLLQTFWRGLGAKESTSGFESQHRLKGIRCSGSVTYKKAKET--------VHSTS 1247

  Fly  1130 YPPKYQESSMCTPPYPLCNPDFTRTLPNPKRH--------SQRNSATGMIEGMQMRSKDDHMLIS 1186
            ......|||:...|.. |.|..:..|.:....        .:||:::..:|.:...
  Fly  1248 DAASNGESSLTKRPNN-CQPSVSIQLQSNMEEKTSKFVLKDERNNSSTEVENIPCN--------- 1302

  Fly  1187 NGLYIPSPSPASSLVIKGSYISSPS-PAP 1214
               .:||       :.:||.|.||. |||
  Fly  1303 ---MVPS-------ITRGSSIESPQRPAP 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	24/90 (27%)
		IG_like	45..137	CDD:214653	25/104 (24%)
		Ig	153..231	CDD:299845	23/98 (23%)
		IG_like	258..342	CDD:214653	26/101 (26%)
		Ig	266..327	CDD:299845	22/74 (30%)
		IG_like	357..>414	CDD:214653	17/65 (26%)
		Ig	360..427	CDD:299845	19/77 (25%)
		Ig	<468..526	CDD:299845	16/68 (24%)
		I-set	547..633	CDD:254352	16/91 (18%)
		Ig	556..631	CDD:299845	14/80 (18%)
		I-set	644..735	CDD:254352	20/127 (16%)
		IGc2	668..725	CDD:197706	15/93 (16%)
		IG_like	751..829	CDD:214653	22/79 (28%)
		IGc2	753..815	CDD:197706	17/63 (27%)
		Ig	852..928	CDD:143165	20/80 (25%)
		FN3	935..1017	CDD:238020	18/143 (13%)
nrm	NP_001246890.1	Ig	44..152	CDD:299845	28/118 (24%)
		Ig	176..248	CDD:299845	22/87 (25%)
		Ig	277..354	CDD:299845	22/79 (28%)
		IG_like	383..463	CDD:214653	22/92 (24%)
		Ig	394..463	CDD:143165	20/81 (25%)
		Ig_3	585..652	CDD:290638	14/82 (17%)
		Ig	685..>719	CDD:299845	9/33 (27%)
		IG_like	788..869	CDD:214653	27/91 (30%)
		Ig	<811..869	CDD:299845	20/68 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810