DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbs and side-VIII

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001097382.2	Gene:	side-VIII / 37310	FlyBaseID:	FBgn0086604	Length:	1201	Species:	Drosophila melanogaster

Alignment Length:	888	Identity:	187/888 - (21%)
Similarity:	298/888 - (33%)	Gaps:	282/888 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 LSVLYPPGAPFFE-GYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSEN 306
            ||.|..|.|.... ..|...|:.|..|.:.|.......||         |...|...|.|||..|
  Fly    18 LSALNGPAAAASRVRVSSSTTMTRNIEEENALLLLLAGPP---------VLSESIMGTVGRLPCN 73

  Fly   307 VYKFTAAAEDNGANLVCEAKNLLATTPLRAE-LNLTVLYAPKDVYLSGANQAKVGDSVQLSCV-T 369
            |                       |.|:..: :.|.:.|             |||....:..| |
  Fly    74 V-----------------------TPPIYEDRVALVIWY-------------KVGLKTPIYSVDT 102

  Fly   370 APSN-----------PQARISWSINGRPLDNSTYKTTSSSDGGW-----------VSSSNISLTI 412
            ..||           .:.|:|:.:.|| ....|.|:|:..|.|.           ..:|.::||:
  Fly   103 RDSNFAQGTHWSDETYRERLSFHVEGR-AGTLTIKSTTEDDTGEYRCRVDFQKSPTRNSKVNLTV 166

  Fly   413 ----------DSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILK 467
                      ||:..|                :..||           |..||:|    ||  :.
  Fly   167 IIPPESVIILDSKGVT----------------IEDHT-----------LGPYNEG----SG--IN 198

  Fly   468 LQCSSAGGNPPPTLQW------YKNDKIINAPSKLVDSKITSELSLL-VNASDNNAIYKCKVQNA 525
            :.|.:.||.|.|.:.|      |||..:   ...|.:.::.:.|||. :...:.:....|:.:|.
  Fly   199 ITCVAIGGRPQPRVTWLHGNTVYKNASV---GQPLSERRVGNTLSLARLERRNLHMQLTCRAENN 260

  Fly   526 AIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLNL 590
            .:..|:.::..|.::..|..||:....:.|..|...:|.|....:.|...|:|||...|::..:.
  Fly   261 NLTTPIISSVVLDMNLRPLIVKLQGENRALSAGNSYQLSCVVIGARPAPTITWWKGSTPMKNTHE 325

  Fly   591 ANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRS-VHETISLDILYPPKFETPQSTTF 654
            ...|   .|:::|..:....|.|..|...:|::...::..| :.:...|||.:.|.......|..
  Fly   326 IATP---DGNLTTSVLTFTPTIDDRGKFLSCRAEQSMIPESGMEDGWKLDIYHIPVVSLELGTNS 387

  Fly   655 VGV---EGAPFHVELLASGNPMVITYTWTKDGLPISSN-----SLSGQRLISDGPRLNISRLSRN 711
            :..   ||.....|.....||.:...:|..:|..:::|     ::|.|.|:       :...||.
  Fly   388 LNSTLREGIDVFFECNIKSNPWIYEVSWRHNGKILTNNPAEGIAVSNQSLV-------LQNASRA 445

  Fly   712 DAGVYICEALNSQGTALLE-IQVAVEYAPTI-----TAVSEGRSFVAGEPAVLACHIQARPLEAA 770
            .:|:|.|...|.:|..... :|:.:.:||..     .:.|.||.    |...:||.|.|.|.||.
  Fly   446 RSGIYTCVGSNREGDGESNPVQLDIRFAPVCRPRQRLSYSSGRH----ETVKVACEIDANPAEAT 506

  Fly   771 HVRWSRDGYDLATRTISSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEI 835
            :| |..:    ||:.                |..||             ||:|         ..:
  Fly   507 YV-WKFN----ATQG----------------ETVDI-------------PASQ---------VAV 528

  Fly   836 DHSPGFTRYAARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALL 900
            |..                  ||:|...|                                   :
  Fly   529 DRG------------------RSIAHYTP-----------------------------------M 540

  Fly   901 IENTSPDDYGQYECVVRNSLGQASTTLEFS--KPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGM 963
            .||    |||...|...|.:|..|....::  ....||..|...|.|.:.||..:....||:||:
  Fly   541 TEN----DYGTLLCWATNEIGDQSEPCVYTIFPAGEPDPLLNCTVLNQTSTGFQIECIEGFNGGL 601

  Fly   964 QTYFRLRLKQHGEDKYKYVDAKPGHQNISLDGLKPGATYYFSVMAANEAGGSKFM---------P 1019
            |..|.:.:..:|..::..: :|.......:.||.||..|...::|.|..|.|...         |
  Fly   602 QQDFIMEVYMNGTTRHPKI-SKSKRPYFEVSGLVPGMGYNVFLIANNSKGRSNATILQVYTLKDP 665

  Fly  1020 D---IKLTLSKGSQPHSAEYT--------------EKDELPNV 1045
            :   :|:|.:|..|.....||              ::||..|:
  Fly   666 EKQTVKITFTKSFQGLRPAYTKTKATATTTSDCVCDEDEFLNL 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653	18/84 (21%)
		Ig	266..327	CDD:299845	12/60 (20%)
		IG_like	357..>414	CDD:214653	19/89 (21%)
		Ig	360..427	CDD:299845	20/99 (20%)
		Ig	<468..526	CDD:299845	15/64 (23%)
		I-set	547..633	CDD:254352	19/86 (22%)
		Ig	556..631	CDD:299845	16/74 (22%)
		I-set	644..735	CDD:254352	21/99 (21%)
		IGc2	668..725	CDD:197706	14/61 (23%)
		IG_like	751..829	CDD:214653	18/77 (23%)
		IGc2	753..815	CDD:197706	15/61 (25%)
		Ig	852..928	CDD:143165	13/75 (17%)
		FN3	935..1017	CDD:238020	24/81 (30%)
side-VIII	NP_001097382.2	Ig	55..166	CDD:299845	32/156 (21%)
		IG_like	60..166	CDD:214653	29/142 (20%)
		Ig	182..266	CDD:299845	24/119 (20%)
		Ig	296..373	CDD:299845	17/79 (22%)
		IG_like	389..464	CDD:214653	18/81 (22%)
		IGc2	394..459	CDD:197706	17/71 (24%)
		Ig_3	490..554	CDD:290638	29/163 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810