DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and IGSF22

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_011518332.1	Gene:	IGSF22 / 283284	HGNCID:	26750	Length:	1346	Species:	Homo sapiens

Alignment Length:	1244	Identity:	259/1244 - (20%)
Similarity:	405/1244 - (32%)	Gaps:	431/1244 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VQKFHLTP-----------HDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYS 91
            |||..||.           .::::.|.:...|.||::::...::|.|||..|....      :||
Human   427 VQKAQLTVDRIPIKFVSNLKNVRVKERSRACLECELTSKDVTLRWKKDGQLLMHGT------KYS 485

  Fly    92 VLVDAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVE 156
            :..:.|:  ..|.|::|.|.|..||                   ::||.......|.|: .|.|.
Human   486 MNHEGKR--AELIIEDAQLSDGGEY-------------------TVVAMQDGDPTEYYS-TAIVT 528

  Fly   157 VEERQNLT------LH---------CIAENANPAAEIVWFQGEVPVSTAP-IVTVNQTAPKRFTT 205
            ||||....      :|         |:..| :...|.||.:....::..| :..|.|.|..:...
Human   529 VEERLATVKSGMSDVHAATGSPAELCVVLN-DEKVEGVWLKDGKEITDLPGMQIVKQGAVHKLIF 592

  Fly   206 SSTLHLQPRAEDDY--KEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQE 268
            .|   :.|..|..|  :....|:.......|.|   .:..|||....|.... ...|.|.|
Human   593 PS---MGPEHEGKYTFRAKGTESEASVFIADPP---TIDPSVLEALAAHAIT-VKVGHTAH---- 646

  Fly   269 VQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVYKFT---AAAEDNGANLVCEAKNLLA 330
            :::..|   |.|..::|||::|:.::..:|.|....|:....|   ...||:|. ::.:.||...
Human   647 IKVPFR---GKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSGL-ILLKLKNDHG 707

  Fly   331 TTPLRAELNLTVLYAPKD-------VYLSGANQAKVGDSVQLSCVTAPSNPQARISWSI----NG 384
            :.  .|.|:|:||..||.       :.|||            |||        .:.|..    .|
Human   708 SA--TATLHLSVLDRPKPPQGRVEFLELSG------------SCV--------HMKWKAPKDNGG 750

  Fly   385 RPLDNSTYKTTSSSDGGWV-------SSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTV-- 440
            ||:.....:..:.....|:       ..:|.|.....:.:.:.....|:|:|...:.:.:..|
Human   751 RPVTQFIVERRAVGKKSWIKIGEVDGKVTNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVFA 815

  Fly   441 -NVLYPP---SPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKIINAPSK------ 495
             |.:.||   |.|.:|......:                    |:.|       |||::
Human   816 GNPIEPPGFASQPQVTDVTKEAV--------------------TITW-------NAPTQDGGAPV 853

  Fly   496 ---LVD-SKITSELSLLVNASDNNAIYKCKV----QNAAIDIPLFATKTLGVHFP--PETVKISV 550
               :|: .|..|.|.:.|| .|.....||.|    ::...:..:.|....|   |  |.....||
Human   854 LGYIVERRKKGSNLWVPVN-KDPIQGTKCTVDGLLEDTEYEFRVIAVNKAG---PGQPSVPSSSV 914

  Fly   551 VPKNLV--PGIRAKLICD---SSSSNPPAKISWWKDGIPVEGLNLANRPGLWGGSVSTLEMYVNI 610
            |.|:.|  ||    |:.|   |.|||....::|.:   |.||
Human   915 VAKDPVKPPG----LVQDLHVSDSSNSSISLAWRE---PAEG----------------------- 949

  Fly   611 TQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVGVEGAPFHVELLASGNPMVI 675
                                           .||               :.:.:|:.|..
Human   950 -------------------------------DPP---------------SGYILEMRAED----- 963

  Fly   676 TYTWTK-DGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQGTALLEIQVAVEYAP 739
            |..|:| ..:|||..                            |..:.    .|:|.|   :|..
Human   964 TKEWSKCTKIPISGT----------------------------CYTVG----GLIERQ---KYFF 993

  Fly   740 TITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDGYDLATRTISSF--ENGTALLQIASVE 802
            .|.||:|..   .|||..|...::|.|..||      ..:||:.|..|..  ..||||
Human   994 RIRAVNEAG---VGEPVELDKGVRAMPPPAA------PKFDLSARLKSHMVVRAGTAL------- 1042

  Fly   803 RSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGFTRYAARLGVRAQLICRSLASPQPSFI 867
                    ||                               :||..|           ||.|..|
Human  1043 --------CI-------------------------------HAAFSG-----------SPPPDVI 1057

  Fly   868 WRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYECVVRNSLGQASTTLEFSKP 932
            |::.|...| .|....||..        .|..||.:|...|.|.|..:::|..|:|...:.....
Human  1058 WQKDGVPTK-GRETITKSKN--------HSQFLINSTKRSDSGVYRILLQNEFGEARYDIHVRVA 1113

  Fly   933 SRPDAPLQLRVGNVSDTGVDLNW--TPGFDGGMQTYFRLRLKQHGEDKYKYVDAKPGHQN-ISLD 994
            ..|..|..||:.......|.|.|  :|......:.:: :.:|:.......|..|:....| .::.
Human  1114 DFPRPPTNLRLFEEVPNTVTLTWNHSPDVQEDGEAHY-IIMKRDASTATWYTAAERVFSNKYTVT 1177

  Fly   995 GLKPGATYYFSVMAANEAGGSKFMP--DIKLTLSKGSQPHSAE---YTEKD--ELPNVMIIGITS 1052
            ||.||..|||.|:|.||.|.|:.:.  |..|......|..||:   |.:||  ..|..:
Human  1178 GLLPGRKYYFRVVARNEIGDSEPLDSRDTWLINKDQIQDLSAKLKPYEKKDWRHAPRFV------ 1236

  Fly  1053 AAMVLLVLNAALVAWFVIRRQNKSQSEAEPSNDDVYSKDDSQSVYKLPITALQADVQKKAAASTY 1117
                     ..|....|:|.|:.:.:.|...|.            :..:|..:.||...|.:..:
Human  1237 ---------TPLKPHTVLRGQDCTMTCAFLGNP------------RPTVTLYKGDVNITANSKFW 1280

  Fly  1118 LVENVDIIQSTAYPPKYQESSMCTPPYPLC----NPDFTRTLPNPKRHSQRNSATGMIEGMQMRS 1178
                   ..||        |.:||...|.|    :.|::..:.| :....|:|.|     :.:..
Human  1281 -------YNST--------SGVCTLVIPTCTLKDSGDYSVLVEN-ELGKDRSSCT-----LTVYD 1324

  Fly  1179 KDDHMLISN 1187
            |||..::::
Human  1325 KDDKSVVAS 1333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	20/88 (23%)
		IG_like	45..137	CDD:214653	19/102 (19%)
		Ig	153..231	CDD:299845	21/95 (22%)
		IG_like	258..342	CDD:214653	22/86 (26%)
		Ig	266..327	CDD:299845	14/63 (22%)
		IG_like	357..>414	CDD:214653	10/67 (15%)
		Ig	360..427	CDD:299845	11/77 (14%)
		Ig	<468..526	CDD:299845	15/71 (21%)
		I-set	547..633	CDD:254352	17/90 (19%)
		Ig	556..631	CDD:299845	13/79 (16%)
		I-set	644..735	CDD:254352	13/91 (14%)
		IGc2	668..725	CDD:197706	8/57 (14%)
		IG_like	751..829	CDD:214653	18/79 (23%)
		IGc2	753..815	CDD:197706	18/63 (29%)
		Ig	852..928	CDD:143165	20/75 (27%)
		FN3	935..1017	CDD:238020	25/84 (30%)
IGSF22	XP_011518332.1	I-set	87..177	CDD:254352
		Ig	104..>164	CDD:299845
		I-set	255..343	CDD:254352
		Ig	264..338	CDD:299845
		I-set	349..434	CDD:254352	4/6 (67%)
		Ig	372..434	CDD:143165	4/6 (67%)
		IG_like	446..529	CDD:214653	25/110 (23%)
		Ig	456..512	CDD:143165	18/82 (22%)
		IG_like	541..618	CDD:214653	15/80 (19%)
		IG_like	637..717	CDD:214653	22/90 (24%)
		Ig_Titin_like	647..717	CDD:143225	19/75 (25%)
		FN3	721..813	CDD:238020	18/111 (16%)
		FN3	822..912	CDD:238020	23/120 (19%)
		FN3	923..1008	CDD:238020	34/203 (17%)
		IG_like	1032..1112	CDD:214653	30/145 (21%)
		Ig_Titin_like	1042..1112	CDD:143225	26/135 (19%)
		FN3	1116..1203	CDD:238020	25/87 (29%)
		I-set	1233..1322	CDD:254352	23/136 (17%)
		Ig	1256..1322	CDD:299845	17/98 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000