DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hbs and HMCN2

DIOPT Version :9

Sequence 1:NP_001286439.1 Gene:hbs / 44129 FlyBaseID:FBgn0029082 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_001278744.1 Gene:HMCN2 / 256158 HGNCID:21293 Length:5079 Species:Homo sapiens


Alignment Length:1154 Identity:280/1154 - (24%)
Similarity:440/1154 - (38%) Gaps:233/1154 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 LRCE-VSNRAGKVQWTKDGFALGFS---AVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQC 118
            |.|| ::..:..:.|.|||.....|   .::||             .:.|||.||..||..:|.|
Human  2570 LICEALAFPSPNITWMKDGAPFEASRNIQLLPG-------------THGLQILNAQKEDAGQYTC 2621

  Fly   119 QVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIAEN-ANPAAEIVWFQ 182
            .|....|. |:: |..:.::..||....:..|.....||:.:.|.||....|: |.|...|.|::
Human  2622 VVTNELGE-AVK-NYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYK 2684

  Fly   183 GEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLY 247
            ...||:.:..:.|       ......|.:||....|...:.|.|.:.|...|......:|:..::
Human  2685 DGQPVTPSSRLQV-------LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMF 2742

  Fly   248 PPGAPFFEGYSQGETLHRGQEVQIACRSRGG---------------------NPPAQLTWYRNGV 291
            .....|...:   |.|.|.:|      :|||                     .||..|||||...
Human  2743 QKVGDFSAAF---EILSREEE------ARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQ 2798

  Fly   292 AISSPQRTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQ 356
            .:|:....|......|.:......:|.....|:|.|.:....|..|  |.||..|  |.|....:
Human  2799 PLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYE--LLVLTPP--VILGDTEE 2859

  Fly   357 ------AKVGDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGG--WVSSSNISLTID 413
                  .....:|.|.| .|..||...|||..||.|...|. :.....||.  .||::.::   |
Human  2860 LVEEVTVNASSTVSLQC-PALGNPVPTISWLQNGLPFSPSP-RLQVLEDGQVLQVSTAEVA---D 2919

  Fly   414 SQSRTFIAVCHALNTELTQNVVGS----HTVNVLYPPSPPLLTGYNDGDI-LISGSILKLQCSSA 473
            :.|...:|          :|..||    .|:.|..||.   :.|.:...: .|..|.:.|.| ..
Human  2920 AASYMCVA----------ENQAGSAEKLFTLRVQVPPR---IAGLDLEQVTAILNSSVSLPC-DV 2970

  Fly   474 GGNPPPTLQWYKNDKIINAPSKLVDSKITSELSLLVNASDNNAIYKCKVQNAA-----------I 527
            ..:|.|.:.|||:.:.::...::.....|..|.|......::.:|.|:..|||           :
Human  2971 HAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL 3035

  Fly   528 DIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLNLAN 592
            ..|.|.....|   |.:.|.:.|       |.:|.|.|::.:. |...::|:|||.|   |.||.
Human  3036 VPPAFRQAPRG---PQDAVLVRV-------GDKAVLSCETDAL-PEPTVTWYKDGQP---LVLAQ 3086

  Fly   593 R-PGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVG 656
            | ..|.||.    .:.:...|..|..:|:|:..| |...:| .|.:|.:..||.||.|::.|...
Human  3087 RTQALRGGQ----RLEIQEAQVSDKGLYSCKVSN-VAGEAV-RTFTLTVQVPPTFENPKTETVSQ 3145

  Fly   657 VEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEAL 721
            |.|:|..:....||.| ..|.||.||.:|:.|:::.|  ::|.|.||.:|||....||.|.|.|.
Human  3146 VAGSPLVLTCDVSGVP-APTVTWLKDRMPVESSAVHG--VVSRGGRLQLSRLQPAQAGTYTCVAE 3207

  Fly   722 NSQGTALLEIQVAVEYAPTI--TAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRD----GYD 780
            |:|..|..:..|||..||.|  :.|:.....:.|:...|.|....:|  ...|.|.:|    |.|
Human  3208 NTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQP--PPDVAWLKDGSPLGQD 3270

  Fly   781 LATRTISSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDH-SPGFTRY 844
            :........:.|:.:|:  .:..||.|.:||:..|..|..|..:.:.|: ..|.|.. :.|....
Human  3271 MGPHLRFYLDGGSLVLK--GLRASDAGAYTCVAHNPAGEDARLHTVNVL-VPPTIKQGADGSGTL 3332

  Fly   845 AARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDY 909
            .:|.|....::|....||.....|.:.|..|.:.:|........         .|.|......|.
Human  3333 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGH---------TLRISKVQLADA 3388

  Fly   910 GQYECVVRNSLGQA--STTLEFSKP-----------------SRPDAPLQLRVGNVSDTGVDL-- 953
            |.:.||..:..|.|  :.||:...|                 |..:.|.:.|       ||.|  
Human  3389 GIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEAR-------GVPLPL 3446

  Fly   954 -NWTPGFDGGMQTYFRLRLKQHGEDKYKYVDAKPGHQNISLDGLKPGATYYFSVMAANEAGGSKF 1017
             :|..  ||  :......|:|              ..::.|:.:..|.:..:|.:|.:|||.:: 
Human  3447 VSWMK--DG--EPLLSQSLEQ--------------GPSLQLEAVGAGDSGTYSCVAVSEAGEAR- 3492

  Fly  1018 MPDIKLTLSKGSQPHSAEYTEKDELPNVMIIGITSAAMVLLVLNAALVAWFVIRRQNKSQSEAEP 1082
             ...:||:.:  .||..:..:..||      .:|..|.:.|:.:|                :..|
Human  3493 -RHFQLTVME--PPHIEDSGQPTEL------SLTPGAPMELLCDA----------------QGTP 3532

  Fly  1083 SNDDVYSKDDSQSVYKLPITALQADVQKKAAASTYL-VENVDIIQSTAY 1130
            ..:..:.| |.|::.:|         :..:.|:..| ||||.:..:..|
Human  3533 QPNITWHK-DGQALTRL---------ENNSRATRVLRVENVQVRDAGLY 3571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbsNP_001286439.1 Ig 44..122 CDD:299845 20/67 (30%)
IG_like 45..137 CDD:214653 23/82 (28%)
Ig 153..231 CDD:299845 19/78 (24%)
IG_like 258..342 CDD:214653 24/104 (23%)
Ig 266..327 CDD:299845 17/81 (21%)
IG_like 357..>414 CDD:214653 17/58 (29%)
Ig 360..427 CDD:299845 20/68 (29%)
Ig <468..526 CDD:299845 13/57 (23%)
I-set 547..633 CDD:254352 24/86 (28%)
Ig 556..631 CDD:299845 23/75 (31%)
I-set 644..735 CDD:254352 35/90 (39%)
IGc2 668..725 CDD:197706 24/56 (43%)
IG_like 751..829 CDD:214653 19/81 (23%)
IGc2 753..815 CDD:197706 16/65 (25%)
Ig 852..928 CDD:143165 16/77 (21%)
FN3 935..1017 CDD:238020 17/84 (20%)
HMCN2NP_001278744.1 VWA_2 39..209 CDD:290253
IG_like 434..513 CDD:214653
Ig 442..503 CDD:299845
IG 524..604 CDD:214652
Ig 534..601 CDD:143165
I-set 608..692 CDD:254352
IGc2 621..684 CDD:197706
IG_like 712..782 CDD:214653
Ig 715..779 CDD:143165
Ig 785..869 CDD:299845
IG 792..879 CDD:214652
I-set 885..972 CDD:254352
IGc2 898..962 CDD:197706
IG 988..1063 CDD:214652
Ig 995..1062 CDD:299845
I-set 1079..1161 CDD:254352
IGc2 1088..1151 CDD:197706
I-set 1165..1246 CDD:254352
IGc2 1179..1236 CDD:197706
IG 1258..1340 CDD:214652
Ig 1266..1340 CDD:299845
IG 1354..1433 CDD:214652
IGc2 1360..1423 CDD:197706
IG 1446..1527 CDD:214652
IGc2 1453..1517 CDD:197706
IG 1540..1620 CDD:214652
Ig 1540..1620 CDD:299845
I-set 1632..1716 CDD:254352
IGc2 1641..1704 CDD:197706
IG 1727..1807 CDD:214652
IGc2 1734..1797 CDD:197706
Ig 1820..1893 CDD:299845
IG_like 1827..1891 CDD:214653
I-set 1895..1975 CDD:254352
Ig 1912..1975 CDD:143165
I-set 1986..2076 CDD:254352
IGc2 2001..2066 CDD:197706
Ig 2079..2169 CDD:299845
I-set 2080..2167 CDD:254352
I-set 2171..2261 CDD:254352
IGc2 2185..2251 CDD:197706
I-set 2273..2355 CDD:254352
Ig 2285..2352 CDD:143165
I-set 2367..2449 CDD:254352
Ig 2379..2449 CDD:299845
Ig 2452..2542 CDD:299845
IG_like 2462..2542 CDD:214653
IG 2558..2638 CDD:214652 23/82 (28%)
IGc2 2565..2628 CDD:197706 20/70 (29%)
IG 2656..2736 CDD:214652 21/86 (24%)
IGc2 2663..2726 CDD:197706 17/69 (25%)
IG_like 2770..2847 CDD:214653 17/78 (22%)
IGc2 2773..2837 CDD:197706 14/63 (22%)
IG 2862..2942 CDD:214652 24/94 (26%)
Ig 2868..2942 CDD:299845 24/88 (27%)
IG_like 2954..3034 CDD:214653 17/80 (21%)
IGc2 2961..3024 CDD:197706 15/63 (24%)
I-set 3038..3129 CDD:254352 32/110 (29%)
IGc2 3056..3119 CDD:197706 23/71 (32%)
I-set 3133..3221 CDD:254352 35/90 (39%)
IGc2 3148..3208 CDD:197706 25/62 (40%)
IG 3234..3318 CDD:214652 20/88 (23%)
IGc2 3240..3306 CDD:197706 17/69 (25%)
IG 3329..3410 CDD:214652 19/89 (21%)
IGc2 3336..3400 CDD:197706 14/72 (19%)
IG_like 3424..3499 CDD:214653 19/101 (19%)
IGc2 3430..3489 CDD:197706 16/83 (19%)
I-set 3503..3590 CDD:254352 20/101 (20%)
IGc2 3518..3580 CDD:197706 15/80 (19%)
I-set 3602..3683 CDD:254352
IGc2 3610..3673 CDD:197706
IG 3693..3774 CDD:214652
Ig 3693..3774 CDD:299845
Ig 3777..3859 CDD:299845
IG 3784..3867 CDD:214652
IG_like 3887..3958 CDD:214653
IGc2 3887..3948 CDD:197706
IG 3968..4048 CDD:214652
Ig 3979..4040 CDD:299845
I-set 4052..4139 CDD:254352
IGc2 4065..4129 CDD:197706
I-set 4143..4228 CDD:254352
IGc2 4157..4218 CDD:197706
I-set 4246..4317 CDD:254352
IGc2 4247..4309 CDD:197706
Ig 4322..4405 CDD:299845
I-set 4323..4409 CDD:254352
G2F 4411..4593 CDD:284812
FXa_inhibition 4652..4687 CDD:291342
EGF_CA 4689..4732 CDD:214542
EGF_CA 4733..4774 CDD:284955
EGF_CA 4776..4815 CDD:284955
EGF_CA 4883..4922 CDD:214542
EGF_CA 4923..4963 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I10780
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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