DRSC/TRiP Functional Genomics Resources

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Protein Alignment hbs and Kirrel2

DIOPT Version :9

Sequence 1:NP_001286439.1 Gene:hbs / 44129 FlyBaseID:FBgn0029082 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_766486.1 Gene:Kirrel2 / 243911 MGIID:2442334 Length:700 Species:Mus musculus


Alignment Length:709 Identity:174/709 - (24%)
Similarity:271/709 - (38%) Gaps:180/709 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQIKNAT 109
            |.|:.:|.|.:..|.|.:....|.|||||||.|||....:||:.||.:..::....::|.||...
Mouse    27 PEDMVVLLGEEARLPCALGAYRGLVQWTKDGLALGGERDLPGWSRYWISGNSASGQHDLHIKPVE 91

  Fly   110 LEDDAEYQCQVGPAAGNPAIRAN-AKL---------SIVAAPSSIVIEGYARNARVEVEERQNLT 164
            |||:|.|:||    |....:|:. |:|         .::..||..::.|...|            
Mouse    92 LEDEASYECQ----ASQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLVAGVPGN------------ 140

  Fly   165 LHCIAE-NANPAAEIVWFQGEVPVSTAPIVTVNQTAPK---RFTTSSTLHLQPRAEDDYKEFSCE 225
            |.|.:. ::.||.|::||:..:.:..:   :.:||..|   ..|..:||.|.|.:.||.....|.
Mouse   141 LTCRSRGDSRPAPELLWFRDGIRLDGS---SFHQTTLKDKATGTVENTLFLTPSSHDDGATLICR 202

  Fly   226 ARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNG 290
            ||.:|||  ......|.||:.|||....   .::.:|:..|::|...|::....|.....|.:.|
Mouse   203 ARSQALP--TGRDTAVTLSLQYPPMVTL---SAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGG 262

  Fly   291 VAISSPQRTSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGAN 355
            ..:...:   |...|.|...|...|.    :.||..|.:.:.  .....|.|||.|       ..
Mouse   263 SPVLGAR---GPRLEVVADATFLTEP----VSCEVSNAVGSA--NRSTALEVLYGP-------IL 311

  Fly   356 QAK-------VGDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTID 413
            |||       ||.....|||.. .||..||:|:..|               |..|.||..:|.:.
Mouse   312 QAKPKSVSVDVGKDASFSCVWR-GNPLPRITWTRMG---------------GSQVLSSGPTLRLP 360

  Fly   414 SQSRTFIA-------VCHALNTELTQNVVGSH------TVNVLYPPSPPLLTGYNDGDILISGSI 465
            |     :|       ||.|   |..:..:|..      |||     :||::|........:.|. 
Mouse   361 S-----VALEDAGDYVCRA---EPRRTGLGGGKAQARLTVN-----APPVVTALQPAPAFLRGP- 411

  Fly   466 LKLQCSSAGGNPPPTLQWYKNDKIINAPSK---LVDSKITSE---------LSLL----VNASDN 514
            .:|||.......|.::.|..::..:.|.|.   ||::....|         :|:|    ...||.
Mouse   412 ARLQCVVFASPAPDSVVWSWDEGFLEAGSLGRFLVEAFPAPEVEGGQGPGLISVLHISGTQESDF 476

  Fly   515 NAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPP------ 573
            ...:.|..:|           .||    ...|:|.:..::|:|.:|  ::..::|:...      
Mouse   477 TTGFNCSARN-----------RLG----EGRVQIHLGRRDLLPTVR--IVAGAASAATSLLMVIT 524

  Fly   574 -AKISWWKDGIPVEGLNLANRPGLWGGSVST-LEMYVNITQDLDGIVYTCQS-----HNEVLQ-- 629
             ..:..|:.|...:..||...||...||.|. .|.....::|...||:|..|     ..|.|:  
Mouse   525 GVVLCCWRHGSLSKQKNLVRIPGSSEGSSSRGPEEETGSSEDRGPIVHTDHSDLVLEEKEALETK 589

  Fly   630 ---------RSVHETISLDILYPPKFETPQSTTF------VGVEGAPF------HVELL 667
                     |.|..::||.       |.|....|      :|:.|.|.      |::|:
Mouse   590 DPTNGYYRVRGVSVSLSLG-------EAPGGGLFLPPPSPIGLPGTPTYYDFKPHLDLV 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbsNP_001286439.1 Ig 44..122 CDD:299845 31/76 (41%)
IG_like 45..137 CDD:214653 35/101 (35%)
Ig 153..231 CDD:299845 20/81 (25%)
IG_like 258..342 CDD:214653 16/83 (19%)
Ig 266..327 CDD:299845 13/60 (22%)
IG_like 357..>414 CDD:214653 18/63 (29%)
Ig 360..427 CDD:299845 20/73 (27%)
Ig <468..526 CDD:299845 16/73 (22%)
I-set 547..633 CDD:254352 23/109 (21%)
Ig 556..631 CDD:299845 20/98 (20%)
I-set 644..735 CDD:254352 8/36 (22%)
IGc2 668..725 CDD:197706 174/709 (25%)
IG_like 751..829 CDD:214653
IGc2 753..815 CDD:197706
Ig 852..928 CDD:143165
FN3 935..1017 CDD:238020
Kirrel2NP_766486.1 IG 27..116 CDD:214652 35/92 (38%)
Ig 122..220 CDD:416386 29/114 (25%)
Ig strand A 123..126 CDD:409353 0/2 (0%)
Ig strand A' 129..133 CDD:409353 2/3 (67%)
Ig strand B 140..147 CDD:409353 3/18 (17%)
Cell attachment site. /evidence=ECO:0000255 146..148 0/1 (0%)
Ig strand C 153..158 CDD:409353 1/4 (25%)
Ig strand C' 161..163 CDD:409353 0/1 (0%)
Ig strand D 166..173 CDD:409353 1/9 (11%)
Ig strand E 180..188 CDD:409353 3/7 (43%)
Ig strand F 197..205 CDD:409353 2/7 (29%)
Ig strand G 211..217 CDD:409353 0/5 (0%)
Ig_3 223..292 CDD:404760 16/78 (21%)
Ig strand B 241..245 CDD:409353 1/3 (33%)
Ig strand C 255..259 CDD:409353 0/3 (0%)
Ig strand E 272..275 CDD:409353 0/2 (0%)
Ig strand F 281..290 CDD:409353 2/12 (17%)
Ig strand G 298..301 CDD:409353 0/2 (0%)
Ig 315..392 CDD:416386 23/100 (23%)
Ig strand A' 316..321 CDD:409353 0/4 (0%)
Ig strand B 324..333 CDD:409353 3/8 (38%)
Ig strand C 339..343 CDD:409353 2/3 (67%)
Ig strand C' 346..348 CDD:409353 1/16 (6%)
Ig strand D 351..354 CDD:409353 1/2 (50%)
Ig strand E 355..360 CDD:409353 1/4 (25%)
Ig strand F 368..376 CDD:409353 3/10 (30%)
Ig strand G 382..392 CDD:409353 1/9 (11%)
Ig 394..498 CDD:416386 24/119 (20%)
Ig strand A 395..399 CDD:409353 2/3 (67%)
Ig strand A' 401..404 CDD:409353 0/2 (0%)
Ig strand B 412..419 CDD:409353 3/6 (50%)
Ig strand C 426..431 CDD:409353 1/4 (25%)
Ig strand C' 433..436 CDD:409353 0/2 (0%)
Ig strand D 444..451 CDD:409353 2/6 (33%)
Ig strand E 461..468 CDD:409353 2/6 (33%)
Ig strand F 479..486 CDD:409353 1/6 (17%)
Ig strand G 489..496 CDD:409353 2/10 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..576 11/33 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..700
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D141865at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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