DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and Igfn1

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_808310.2	Gene:	Igfn1 / 226438	MGIID:	3045352	Length:	2849	Species:	Mus musculus

Alignment Length:	871	Identity:	193/871 - (22%)
Similarity:	284/871 - (32%)	Gaps:	260/871 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 YPPGA--------PFFEGYSQGET---LHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQRT- 299
            |.||.        ...:.:|||.|   :..|:...::|.......|.  ||:::||.:::....
Mouse  2038 YQPGTGRSSSEARGSMDHFSQGLTDTEVQLGEAAIVSCTLASDLGPG--TWFKDGVKLTAQDGVI 2100

  Fly   300 ------SGRL--------SENVYKFTAAAEDNGANLVCEAKNLLA---TTPLRAELNLTVLYAPK 347
                  :.||        ....|.|.|..:.:.|:|..:....:|   |..||..|   |..|.|
Mouse  2101 FEQDGLTHRLILTHVEGTQAGKYTFVAGCQHSEASLTVQDPPTIAPDVTETLREPL---VFKAGK 2162

  Fly   348 DV---------------YLSGANQAKVGD--SVQLSCVTAPSNPQARISW----SINGRPLDNST 391
            .|               :....|:...||  .:||:....       .:|    |:..:  |:..
Mouse  2163 PVTVKIPFQSRLPVQAAWRKDGNEVVGGDHKGIQLALADG-------YTWLCLPSVCRK--DSGR 2218

  Fly   392 YKTTSSSDGGWVSSSNISLTIDS----QSRTFIAVCHALNT------------ELTQNVV----- 435
            |..|..|:||.|.:......||.    |....:..||....            ::.|:.|
Mouse  2219 YSVTLRSEGGCVQAEFTLQVIDKPQPPQGPLEVQDCHRAGVCLRWLPPRDNGGQVIQHYVVERRQ 2283

  Fly   436 -GSHT-VNVLYPPSPPLLTGYND---------------------GDILISGSILKLQCSSAGGNP 477
             |..| :.|..|||..  |.:.|                     ||.|.|..:|....:..|  |
Mouse  2284 AGRSTWLKVGEPPSDS--TSFTDTSVEQGKKYAFRVRAVTSVGAGDALESEEVLVAPEALPG--P 2344

  Fly   478 PP------------TLQW----------------YKNDKIINAPSKLVDSKITSELSLLVNASDN 514
            |.            ||.|                .|:.|..|. ...|:.:..||....|.....
Mouse  2345 PSAPAILSASSQSITLTWGAPQGPGSNHILGYLIEKHKKGSNT-WMAVNEQPVSERRYTVVGLRQ 2408

  Fly   515 NAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWW 579
            ...|:.:|....:..|       |...||.....:..|......:|...:.|  :||....:||.
Mouse  2409 GCQYEFRVTAVTLSGP-------GDPGPPSDAVFARDPMRPPGPVRDLQVTD--TSNTSITVSWM 2464

  Fly   580 ----KDGIPVEG--LNLAN---------RPGLWGGSVSTLE-------MYVNITQDLDGIVYTCQ 622
                :|....:|  :.|..         ..|...|:..|.:       .:|.:|...||    .:
Mouse  2465 VPDARDADEAQGYIVELCGSDSHQWSPCHVGTVPGTTFTAKGLRPQEGYFVRVTAVNDG----GR 2525

  Fly   623 SHNEVLQRSVHETISLDILYPPKFETPQST--TFVGVEGAPFHVELLASGNPMVITYTWTKDGLP 685
            |....|...||   ::.....|:|.....|  |.:...|....|.|.....||. ..||.|||||
Mouse  2526 SQATSLDTLVH---AMPATVCPRFLMDSGTKDTLMVRVGDSIRVPLSFEAAPMP-EVTWLKDGLP 2586

  Fly   686 ISSNSLSGQRLISDG-PRLNISRLSRNDAGVYICEALNSQG---TALLEIQVAV-EYAPTITAVS 745
            :...|::   .:..| .:|.|...|.:|.|.|.....|.||   |....|.||. ..||....:.
Mouse  2587 LPKRSVT---TVKAGLTQLLIPAASLSDCGRYTVMLRNLQGKEATHSFFINVAACPQAPGSIYLQ 2648

  Fly   746 E---GRSFVAGEPAVLACHIQARPLE----------------AAHVRWSR-------DGYDLATR 784
            |   |...|..||:  ....|..||.                |.|||.:|       .|::...|
Mouse  2649 ENVPGTVTVQWEPS--PDEAQGIPLHYTVLMRSSSHRSWHEVADHVRTNRFTLLGVLPGHEYHFR 2711

  Fly   785 TISSFENGTALLQIASVERSDIGNFTCIVDNQRG-----APAAQNVLLVVQTAPEIDHSPGFTRY 844
            .::..|.|.:       :.||.....|| ..||.     :|..|:        |::...|.|.
Mouse  2712 VLAKNELGVS-------KPSDTSQPWCI-PRQRDRFTVKSPTYQD--------PDLSQKPRFL-- 2758

  Fly   845 AARLGVRAQLI---------CRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALL 900
               :|:||.|:         |....||||...|.::.:.|.   ||   ......|.|.. .:|:
Mouse  2759 ---VGLRAHLLPQGCECRMTCAVQGSPQPHVTWFKNDQSLD---RN---PAVYSTDLLGV-CSLV 2813

  Fly   901 IENTSPDDYGQYECVVRNSLGQASTT 926
            |.:.|..|.|:|:.|.:|.||||.:|
Mouse  2814 IPSVSLKDSGEYKAVAKNPLGQAVST 2839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653	23/104 (22%)
		Ig	266..327	CDD:299845	14/75 (19%)
		IG_like	357..>414	CDD:214653	14/62 (23%)
		Ig	360..427	CDD:299845	18/76 (24%)
		Ig	<468..526	CDD:299845	15/85 (18%)
		I-set	547..633	CDD:254352	19/107 (18%)
		Ig	556..631	CDD:299845	18/96 (19%)
		I-set	644..735	CDD:254352	30/96 (31%)
		IGc2	668..725	CDD:197706	18/57 (32%)
		IG_like	751..829	CDD:214653	23/105 (22%)
		IGc2	753..815	CDD:197706	18/84 (21%)
		Ig	852..928	CDD:143165	26/84 (31%)
		FN3	935..1017	CDD:238020
Igfn1	NP_808310.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..108
		I-set	187..278	CDD:254352
		Ig	204..278	CDD:299845
		IG_like	467..554	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..600
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..760
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..924
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1061..1103
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1312..1338
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1350..1384
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1498..1523
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1654..1675
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1724..1780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1827..2055		3/16 (19%)
		I-set	2055..2138	CDD:254352	18/84 (21%)
		IG_like	2154..2238	CDD:214653	19/95 (20%)
		Ig	2163..2238	CDD:299845	15/83 (18%)
		FN3	2242..2334	CDD:238020	17/93 (18%)
		FN3	2342..2434	CDD:238020	19/101 (19%)
		FN3	2443..2530	CDD:238020	17/92 (18%)
		IG_like	2555..2635	CDD:214653	26/83 (31%)
		Ig	2563..2635	CDD:299845	24/75 (32%)
		FN3	2639..2728	CDD:238020	21/97 (22%)
		I-set	2755..2844	CDD:254352	30/97 (31%)
		Ig	2773..2841	CDD:143165	24/74 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000