DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and syg-2

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001309674.1	Gene:	syg-2 / 181561	WormBaseID:	WBGene00007750	Length:	1230	Species:	Caenorhabditis elegans

Alignment Length:	1237	Identity:	359/1237 - (29%)
Similarity:	542/1237 - (43%)	Gaps:	174/1237 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QKFHLTPHDLQILEGTDTLLRCEVSNRAGKV---QW-TKDGFALGF--SAVIPGFP-RYSVLVDA 96
            |.|..:|.:|..:.|.....||........:   || :..|..||:  ..::||.. |:|.:
Worm    19 QFFLESPSNLSTIAGESITFRCSAEKSPEPIVYSQWKSNTGSLLGYHQEGILPGHQGRFSYI--- 80

  Fly    97 KQNAYNLQIK--NATLEDDAEYQCQV-----GPAAGNPAIRANAKLSIVAAPSSIVIEGYARNAR 154
            ||||..|.:|  :..|:||.||:||:     ||      |||.:.|:|:..|..:....|..|:.
Worm    81 KQNAEELHLKITHVNLDDDGEYECQMLHPEEGP------IRAKSFLNIIVPPQLVYFSNYQPNSI 139

  Fly   155 VEVEERQNLTLHCIAENANPAAEIVWF-QGEV---PVSTAPIVTVNQTAPKRFTTSSTLHLQPRA 215
            :.|:|...|.:.|:..|..|..|::|: .|:|   .|..|....:|:|    ||..::|.:|...
Worm   140 IAVKENTPLNITCVVPNVKPEPEVLWYMDGKVMSRDVKQASTPHLNKT----FTVYTSLVVQSDR 200

  Fly   216 EDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNP 280
            .|..|..:|||..|  ..|:.:.....|.||:||..|..|.......|..|..|.|||...||||
Worm   201 NDHGKVITCEAFQK--ETDIRITTNTTLDVLFPPSDPTVEILRNPSALRSGDNVTIACSVTGGNP 263

  Fly   281 PAQLTWYRNGVAISSPQRTSGRLSE--NVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVL 343
            |..:.||.....:.|......|..|  |:|.|.|:..||.|...|.|.|.....|.|..:.|.|.
Worm   264 PPDVFWYHENKRLQSHSTLDTRSKEIKNIYSFIASQNDNMAEYECRANNSRTGNPKRKAMKLEVN 328

  Fly   344 YAPKDVYLSGANQAKVGDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNI 408
            |.|..|.|.|.:..:.|.|..:.|.:.||||.::|:|.||||.:...|.: ....:.|.|||||:
Worm   329 YPPASVELFGESNIRYGSSANIQCKSLPSNPASQITWIINGRSVPTPTQR-EFVVENGIVSSSNV 392

  Fly   409 SLTIDSQSRTFIAVCHALNTE-LTQNVVGS----HTVNVLYPPSPPLLTGYNDGDILISGSILKL 468
            |:    .|.......|.:|.| :..|..||    |.:.::.||..|::||..|.. ...|.|:.:
Worm   393 SV----HSNELSVEAHQINVECMATNPEGSSAKQHVIKIIAPPKAPIITGLEDRK-FFEGDIVNV 452

  Fly   469 QCSSAGGNPPPTLQWYKNDK--IINAPSKLVDSKIT------------SELSLLVNASDNNAIYK 519
            .|.:.||||...|.||:..:  ::....|:..|::.            |.|:|.|:.:.|....|
Worm   453 TCEAQGGNPLAELSWYRGSEKHLVKGRKKMKWSQVNGAHNEVAGFSSYSTLALRVDRTMNTQRLK 517

  Fly   520 CKVQNAAIDIPLFATKTLGVHFPPETVKISVV---PKNLVPGIRAKLICDSSSSNPPAKISWW-- 579
            |:..|||:|.||..::.|.|::||..|.|...   .:.|:.|..|:|:|.:.||||.|.|||.
Worm   518 CEATNAALDEPLIESQYLSVYYPPRRVLIRPADSGDQRLLVGKSARLVCGTLSSNPAAHISWQFS 582

  Fly   580 ------KDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISL 638
                  |..:....||...|..  |.:|..:..:.. |::.||.|..|.:::...:.||:.:..|
Worm   583 RATDDNKVHLGDVSLNETTRDN--GFNVENVLSFTP-TEEYDGTVVHCIANHPEWKHSVNTSFPL 644

  Fly   639 DILYPPKFETPQSTTFVGVEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRL 703
            :::||||.......|.|..||..|...|...|||.:..:.|.|:|:|.....   .|:.:.|..|
Worm   645 NVMYPPKMLVNDPVTVVMSEGDSFKENLTVRGNPAISLWQWRKNGVPFDHTI---GRVFARGAVL 706

  Fly   704 NISRLSRNDAGVYICEALNSQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLE 768
            :..:|...|||||...|.||.|:..:.|::||||:..||::|.......|:..:|.|.....|.:
Worm   707 SGKQLLSTDAGVYTLTATNSVGSTNITIKLAVEYSARITSISTPVIAATGDTVLLECEADGEPSK 771

  Fly   769 AAHVRWSRDGYDLATRTISSFENG--TALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQT 831
            |..:.|.::|..||.:     ..|  .|:|::.:.|:.. |.:||..||..|.||.....|:|.:
Worm   772 ANMIHWYKNGEILAAQ-----HRGHKKAILRLNATEQQS-GEYTCKADNGIGVPAEGQTFLLVNS 830

  Fly   832 APEIDHSPGFTRYAARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRN--KFKSVERQVDALN 894
            ||.:.....:.:.|..||..|:..|:..|.|...|:|.   ||.::.::|  |:..|..|:|...
Worm   831 APRVLPVARYAKTAGILGGVAKARCKVYAVPTVEFVWE---KDEQLIKKNSSKYSIVNTQIDYST 892

  Fly   895 FESALLIENTSPDDY-GQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPG 958
            :||.|.|:|..|||| .:.:|:.|||.|....::....|:.||.|..|.:.|.:...:.:.|.|.
Worm   893 YESTLWIKNIVPDDYTKKVKCIARNSFGTDHLSIPIIPPTHPDEPFNLTMTNSTLNTISVAWEPR 957

  Fly   959 FDGGMQTYFRLRLKQHGEDKYKYVDAKPGHQNISLDGLKPGATYYFSVMAANEAG--GSKFMPDI 1021
            ||||....|.::.::..:|....|:..  |.|:.|.||....||:|.:.:.|..|  .|...|.|
Worm   958 FDGGSDQIFEVKYRRQNDDLIHLVNTT--HTNLRLSGLATANTYFFQIRSINARGFASSWTSPVI 1020

  Fly  1022 KLTLSKGSQPHSAEYTEKDEL----PNVMIIGITSAAMVLLVLNAALVAWFVIRRQNKSQSEAEP 1082
            ..||::.....:....||.:|    |.::|.      :||.:|...::..||..|..|.:...:.
Worm  1021 FATLNEDGVNVAMIRNEKLKLTTWIPYILIF------IVLFMLLNVVICCFVCNRTKKRKLREKT 1079

  Fly  1083 ----------------------SNDDVYSKD---------DSQSV----------YKLPITALQA 1106
                                  .||.:..:|         |..||          |..||..:
Worm  1080 EMARTAINGGDVRQVQMYGTMMGNDGMSRRDIDDRPEMSEDEHSVRTMIEVSPNGYMQPIEPM-- 1142

  Fly  1107 DVQKKAAASTYLVENVDIIQSTAYPPKYQESSMCT-------PPYPLCNPDFTRTLPNPKRHSQR 1164
                       |.|:..:::.......|..||..|       .|||  .|      |.|..||..
Worm  1143 -----------LYESTGLLEYDYQTRSYMGSSQGTRSMTYANVPYP--EP------PQPSYHSNW 1188

  Fly  1165 NS 1166
            ||
Worm  1189 NS 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	27/91 (30%)
		IG_like	45..137	CDD:214653	33/105 (31%)
		Ig	153..231	CDD:299845	24/81 (30%)
		IG_like	258..342	CDD:214653	29/85 (34%)
		Ig	266..327	CDD:299845	24/62 (39%)
		IG_like	357..>414	CDD:214653	21/56 (38%)
		Ig	360..427	CDD:299845	23/66 (35%)
		Ig	<468..526	CDD:299845	18/71 (25%)
		I-set	547..633	CDD:254352	26/96 (27%)
		Ig	556..631	CDD:299845	23/82 (28%)
		I-set	644..735	CDD:254352	29/90 (32%)
		IGc2	668..725	CDD:197706	19/56 (34%)
		IG_like	751..829	CDD:214653	22/79 (28%)
		IGc2	753..815	CDD:197706	16/63 (25%)
		Ig	852..928	CDD:143165	27/78 (35%)
		FN3	935..1017	CDD:238020	25/83 (30%)
syg-2	NP_001309674.1	IG_like	25..105	CDD:214653	25/82 (30%)
		Ig	33..122	CDD:299845	31/97 (32%)
		Ig	147..228	CDD:299845	24/86 (28%)
		IGc2	248..313	CDD:197706	24/64 (38%)
		Ig	450..537	CDD:299845	24/86 (28%)
		Ig	559..632	CDD:299845	23/75 (31%)
		I-set	657..738	CDD:254352	27/83 (33%)
		Ig	665..738	CDD:299845	24/75 (32%)
		IG_like	748..828	CDD:214653	23/85 (27%)
		IGc2	756..817	CDD:197706	18/66 (27%)
		Ig	845..922	CDD:299845	29/79 (37%)
		FN3	934..1023	CDD:238020	27/90 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I7498
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137806
Inparanoid	1	1.050	438	1.000	Inparanoid score	I938
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28764
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0005450
OrthoInspector	1	1.000	-	-		otm14539
orthoMCL	1	0.900	-	-		OOG6_107508
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840