DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and igcm-2

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	822	Identity:	185/822 - (22%)
Similarity:	303/822 - (36%)	Gaps:	223/822 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 NDGDILI----SGSILKLQCSSAGGNPPP-TLQWYKNDKIINAPSKLVDSKITSELS-------- 506
            :||::..    :|:.:.|.||.:..|... :|.|.|:.::|.:........:|..|.
Worm    16 DDGEMKAYWGKAGAPITLPCSISLFNEESFSLDWRKDGQLILSAFGQEQGHVTPTLQGRLARDGF 80

  Fly   507 ---LLVNASDNNA-IYKCKVQNAAIDIPLFATKTLG----VHFPPETVKISVVPKNLV--PGIRA 561
               .:.:.:|.:| :|:|.|...:.. |....|.|.    |:.||..:..|   ||.:  ..:.|
Worm    81 LGITIHSVTDGDAGVYQCIVTKFSKQ-PTRPEKGLSAKLVVNVPPVIISPS---KNAIIHKKVGA 141

  Fly   562 KLICDSSSSNPPA-KISWWKDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTC---- 621
            .||.:..:...|: :|:|.::    |.: ::..|.|   ::|.||       :.|..:|||
Worm   142 DLIFECKAEGAPSPEITWSRN----EQI-ISTSPVL---TLSNLE-------EGDKGLYTCLAVN 191

  Fly   622 ---QSHNEVLQRSVHETISLDILYPPKFETPQSTTFVGVEGAPFHVELLASGNPMVITYTWTKDG 683
               .|.:.:..|....|| ||::       |.:.|.  :||:.......|:.....|:|:|..:.
Worm   192 IEGNSTSSIDVRFTKATI-LDLI-------PLNKTV--IEGSNVFWHCHANAQATAISYSWLFEK 246

  Fly   684 LPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQG-----TALLEIQVAVEYAP---- 739
            .||.:.||..:..|..|. |::..:.::|:|.|.|||.||.|     ||.|.    |.|.|
Worm   247 KPIKTTSLGLRSNIRSGD-LSLQDVRKSDSGWYTCEAKNSAGETTSSTAYLH----VFYPPEPLS 306

  Fly   740 ---TITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDGYDLATRTISSFENGTALLQIASV 801
               .:..|:.||:      ..::|.:.|.|...::. ||::|:.|.|:..|.       :.|:..
Worm   307 SHQPVQTVASGRN------TTVSCDVIANPTPTSYT-WSKNGHYLPTQASSH-------IIISYA 357

  Fly   802 ERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGFTRYAARLGVRAQLICRSLASPQPSF 866
            :..|.|.:.|..||..|..:.....|:|...|....:|. :....|||.:..:.|:....|.|..
Worm   358 KPGDGGIYGCQADNIAGKGSIVETHLIVAEPPVFTVAPP-SEIKVRLGDQVSIPCQGFGDPMPIV 421

  Fly   867 IWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYECVVRNSLGQAST----TL 927
            .|.|..|.:. |....||.||..                  |:|.|||||.||:...||    .:
Worm   422 YWIRDKKRIN-QSTLTFKKVEHL------------------DHGAYECVVANSVETISTRVMLLV 467

  Fly   928 EFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQTYFRLRLKQHGED--KYKYVDAKPGHQN 990
            |.:||....:   ::...::.:.:.::||||::||....|.:    |.::  ..::...|.....
Worm   468 EITKPQMASS---IKFTCLNSSSMRISWTPGYNGGFDQTFAV----HAQNDVTLQWTSIKTSLNE 525

  Fly   991 ISLDGLKPGATYYFSVMAAN------------------------------------EAGGSKFMP 1019
            ..||.|:|..:|..|:.:.|                                    ..|.|.:..
Worm   526 TILDHLEPFVSYRVSIESVNAKGSTNSTTYNRRSCTSLHAPDKLYFCGYNELCWTAAEGASSYRI 590

  Fly  1020 DIKLTLSKGSQPHSAEYTE------KD---------------------ELPNVMIIGITS----- 1052
            :.:...||..|| .||..|      ||                     |..|.:..||..
Worm   591 ESRTEPSKNFQP-LAEVLETYYRLGKDVDETKQTIFRVRSTRPSYPPSEPSNALRYGIADNVDLP 654

  Fly  1053 ----AAM--VLLVLNAALVAWFVIRRQN------KSQSEAEPS-----------NDDVYSKDDSQ 1094
                ||:  :|......|.||.....:|      ||:|.:.||           .|...|.....
Worm   655 IFMLAAVFGLLFCFACGLFAWRCFHNKNKKSKRRKSRSNSTPSKTYQDYGRFTYGDGSSSSQPGT 719

  Fly  1095 SVYKLPITALQADVQKKAAASTYLVENVDIIQSTAYPPKYQE 1136
            ..|..|...|..|.:.:....   :|.|    :..|||...|
Worm   720 ETYYEPSLRLLDDHEWRGPRD---LEPV----AVRYPPSLAE 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653
		Ig	266..327	CDD:299845
		IG_like	357..>414	CDD:214653
		Ig	360..427	CDD:299845
		Ig	<468..526	CDD:299845	15/70 (21%)
		I-set	547..633	CDD:254352	21/95 (22%)
		Ig	556..631	CDD:299845	17/84 (20%)
		I-set	644..735	CDD:254352	27/95 (28%)
		IGc2	668..725	CDD:197706	19/56 (34%)
		IG_like	751..829	CDD:214653	17/77 (22%)
		IGc2	753..815	CDD:197706	13/61 (21%)
		Ig	852..928	CDD:143165	22/79 (28%)
		FN3	935..1017	CDD:238020	18/119 (15%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	15/77 (19%)
		Ig	124..200	CDD:386229	21/93 (23%)
		IG_like	214..298	CDD:214653	27/90 (30%)
		Ig_3	309..371	CDD:372822	16/75 (21%)
		Ig	389..467	CDD:386229	27/97 (28%)
		FN3	476..548	CDD:238020	16/78 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020