DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and igcm-1

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_508166.1	Gene:	igcm-1 / 180433	WormBaseID:	WBGene00018215	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	1072	Identity:	226/1072 - (21%)
Similarity:	375/1072 - (34%)	Gaps:	369/1072 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 DSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSD-------GGWV-----SSSNISLTID 413
            :.:.:.||..|.... |..:.||....:|...:..:.:|       ..::     ::.|.||.|.
Worm    43 EGIVIPCVVKPEYFD-RQKYEINWARYNNGQLRMITKNDKLLAKKHSRFILENDSATGNYSLRIT 106

  Fly   414 SQSRTFI-AVCHALNTELTQNVVGSH----------TVNVLYPPSPPLLTGYNDGDILISGSILK 467
            ...:..: ...|.       ||:|:.          ||.||.||..|::: ....:.:|.|..:.
Worm   107 EVEKNSVEGTYHC-------NVIGTDDSDVQYSALATVVVLVPPGDPIIS-TTPSESVIEGDFMT 163

  Fly   468 LQCSSAGGNPPPTLQW-YKNDKIINA---PSKLVDSKITSELSLLVNASDNNAIYKCKVQNAAI- 527
            .:|.|.||:|.||..| ..||.|.::   .::..|....|.|...|.:||:....:|.|.|.|:
Worm   164 AKCVSVGGSPQPTFTWTLPNDTIASSAIFTTQFRDGATESLLHFRVTSSDDGKSVQCDVTNRAML 228

  Fly   528 --DIPLFATKTLGVHFPPETVKISVVP-KNLV-----PGIRAKLICDSSSSNPPAKISWWKDGIP 584
              :.....:..|.|.:.|   .:.|.| :||.     .|....|.| :|:|||||....||
Worm   229 GGETKQVKSSQLNVLYKP---VVFVTPTENLTHLSVEEGELVNLTC-NSASNPPAHSYEWK---- 285

  Fly   585 VEGLNLANRPGLWGGSVSTLEMY------VNITQDLDGIVYTCQSHNE----------VLQR--- 630
                           .:::.|.|      :.:...:.| .:.|:|.||          |:|.
Worm   286 ---------------HIASGERYQGKIWPIRVDSSMSG-DFECRSTNELGEGTAVLKMVVQHIPR 334

  Fly   631 -SVHETIS------LDILY---------------PPKFETPQS---------------------- 651
             :|.|:||      :|||.               |..|:...|
Worm   335 INVPESISPNEMEDIDILCEVSAVPEVIDIKWVGPNGFKQNGSRLTITSISKAQSGNYTCMATNF 399

  Fly   652 ----------------TTFVGVEGAPFHVELLA-------------------SGNPMVITYTWTK 681
                            ||.|.|:..|...::::                   :|||.. :|||..
Worm   400 LTVYGHSGSQQRMGTGTTIVDVKRKPGQAQIVSARQNVDVGETIKLMCQAEDAGNPSA-SYTWAS 463

  Fly   682 DGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQ-----GTALLEIQVAVEYAPTI 741
            .    ||..:.|....:: ....:.....:|.|||.|:|.|..     ||.::.:   :|.|...
Worm   464 P----SSGGIFGLEGHTE-KSFEVRNAQLSDNGVYSCKAYNDLGEGKIGTVMITV---IEKARIS 520

  Fly   742 TAVSEGRSFVAGEPA-VLACHIQARPLEAAHVRWSRDG--------------------YDLATRT 785
            :.::..|.|.:||.. :|.|..|..|  :..::|.:||                    .|..|:|
Worm   521 SPLATERIFTSGEQGKILECEAQGYP--SPVIKWLKDGRPVKQSIYASSATSESKCLPEDFCTQT 583

  Fly   786 ISSFENGTALLQIASVERSDIGNFTCIVDNQRGA------PAAQNVLLVVQTAPEIDHSPGF--- 841
            ::|     .|.....::.||.|||||:.||  |:      .::..::.|:       |.|.|
Worm   584 VAS-----TLTLAGPLKWSDKGNFTCVADN--GSDKTDKDSSSWTIVRVL-------HKPVFLNR 634

  Fly   842 -----TRYAARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLI 901
                 :..||.:|.:|.:.|:..|.|:|.|.|.....::....|:.|.:|........:|..|.|
Worm   635 KFPEKSLAAADIGSQAIIRCKVSARPEPEFHWMFRDSEISENERHSFHTVGITGKPDEYEQLLQI 699

  Fly   902 ENTSPDDYGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGM-QT 965
            |:....|||:|.|...|..|.....:|..|.|.|..||.|:..:.:...|.|.|.|.||||. ||
Worm   700 ESVQESDYGEYVCRATNGNGGDHVVIELRKTSPPALPLDLQKLSATSNSVLLGWVPQFDGGADQT 764

  Fly   966 YF--------------------RLRLKQHGEDKYKYVDAKPGHQNI-SLDGLKPGATYYFSVMAA 1009
            |.                    :|.:....:|  :.:|.....:|| :..||.|.:||...:.|.
Worm   765 YVLETRKIDPFTGEIDGNAPVSKLNINAVQQD--QEIDGTLVSKNIFNFTGLTPLSTYNLRIQAV 827

  Fly  1010 NEAGGSKFMP-------DI----------KLTLSKGSQPHSAE---------------------- 1035
            :|.|.|:|.|       |:          :|.|....|..:.|
Worm   828 SEKGESEFTPVLIASTEDVVEDANMMSPSRLVLDSSEQKINVEPKLPSDACTLLYVFLDGIWRTS 892

  Fly  1036 --YTEKDELPNVMIIG----------------------ITSAA------------MVLLVLNAAL 1064
              :|..:.:.|: |.|                      |:|.:            :..:.:..|:
Worm   893 TCHTSSNPIGNI-IPGREYRARFCTTANGLKCSPVSKTISSGSGSVWKTNVFFPFLFFIFIGLAI 956

  Fly  1065 VAWFVI---RRQNKSQSEAEP------SNDDV-----------------------YSKDDSQSVY 1097
            ..:|::   .|.|...|:..|      ..|::                       .|:.|::|.
Worm   957 CVFFLVCCKTRSNPKTSKLSPIILTSLPGDELKRPADYEEPKHATFAITENETNHLSQHDAKST- 1020

  Fly  1098 KLPITALQADVQKKAAASTYLVENVDIIQSTA 1129
            |.|...::.||    :...||.||.:::::|:
Worm  1021 KPPGLNMEYDV----STDCYLQENTEVLKNTS 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653
		Ig	266..327	CDD:299845
		IG_like	357..>414	CDD:214653	12/64 (19%)
		Ig	360..427	CDD:299845	13/78 (17%)
		Ig	<468..526	CDD:299845	20/61 (33%)
		I-set	547..633	CDD:254352	24/111 (22%)
		Ig	556..631	CDD:299845	20/99 (20%)
		I-set	644..735	CDD:254352	25/152 (16%)
		IGc2	668..725	CDD:197706	16/80 (20%)
		IG_like	751..829	CDD:214653	24/104 (23%)
		IGc2	753..815	CDD:197706	21/82 (26%)
		Ig	852..928	CDD:143165	21/75 (28%)
		FN3	935..1017	CDD:238020	29/103 (28%)
igcm-1	NP_508166.1	Ig	45..119	CDD:299845	12/74 (16%)
		Ig	146..226	CDD:299845	23/80 (29%)
		Ig_3	245..316	CDD:290638	21/94 (22%)
		IG_like	258..329	CDD:214653	18/91 (20%)
		IG_like	338..398	CDD:214653	9/59 (15%)
		IGc2	347..398	CDD:197706	6/50 (12%)
		Ig_2	429..513	CDD:290606	18/89 (20%)
		IG_like	437..513	CDD:214653	18/81 (22%)
		Ig	537..615	CDD:143165	22/86 (26%)
		IG_like	644..728	CDD:214653	24/83 (29%)
		IGc2	646..719	CDD:197706	21/72 (29%)
		FN3	733..843	CDD:238020	31/111 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910