DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and MYOM3

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_689585.3	Gene:	MYOM3 / 127294	HGNCID:	26679	Length:	1437	Species:	Homo sapiens

Alignment Length:	1186	Identity:	223/1186 - (18%)
Similarity:	376/1186 - (31%)	Gaps:	398/1186 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 HRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVYKFTAAAEDNGANLVCEAKNL 328
            ||.:|.|...|...         .|.|   ||.:|.:.|.||..::|:||.....|.|...|.:.
Human    26 HRQEEEQKEERQHS---------LRMG---SSVRRRTFRSSEEEHEFSAADYALAAALALTASSE 78

  Fly   329 LA-TTPLRAELNLTVLYAPKDVYLSGANQAKVG-----DSVQLSCVTAPSNPQARISWSINGRPL 387
            |: ...||.:.:.        |.|....|.:||     :..:::.:......:.|..|....|..
Human    79 LSWEAQLRRQTSA--------VELEERGQKRVGFGNDWERTEIAFLQTHRLLRQRRDWKTLRRRT 135

  Fly   388 DNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALN----TELTQNVVGSHTVNVLYPPSP 448
            :...                      .:::....:|:...    ..|..:.|..||.
Human   136 EEKV----------------------QEAKELRELCYGRGPWFWIPLRSHAVWEHTT-------- 170

  Fly   449 PLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKIINAPSKLVDS---KITSE---LSL 507
                             :.|.| :...:|||.:.|||||..|:  .:|..:   :||:.   |||
Human   171 -----------------VLLTC-TVQASPPPQVTWYKNDTRID--PRLFRAGKYRITNNYGLLSL 215

  Fly   508 LVN--ASDNNAIYKCKVQN--------------------AAIDIPLFATKTLGVHFPPETVKISV 550
            .:.  |.:::|.|..:|:|                    |..|..:|...|.|......:|...|
Human   216 EIRRCAIEDSATYTVRVKNAHGQASSFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPV 280

  Fly   551 VPKNLVPGIRAKLICDSSSSNPPAK-ISWWKDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQDL 614
            ..:...|   ..|.|..|.....|: |.|::||..:.  :...|..|:....::|::.....:|
Human   281 FAREKEP---FSLSCLFSEDVLDAESIQWFRDGSLLR--SSRRRKILYTDRQASLKVSCTYKED- 339

  Fly   615 DGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFV----------GVEGAPFHVELL-A 668
            :|:..                    :..|..|...:.:|:|          |..|:|.:|..| .
Human   340 EGLYM--------------------VRVPSPFGPREQSTYVLVRDAEAENPGAPGSPLNVRCLDV 384

  Fly   669 SGNPMVITYTWTKD--GLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQGTALLEI 731
            :.:.:::|:....|  |.||::.::               ...:.::|.:|.......||....|
Human   385 NRDCLILTWAPPSDTRGNPITAYTI---------------ERCQGESGEWIACHEAPGGTCRCPI 434

  Fly   732 QVAVE---YAPTITAVSEGRSFV---AGEPAVLACHIQAR-----PLEAAH-VRWSRDGYDLATR 784
            |..||   |...:.|:|...|.|   |.|..|:..|..||     |.:..: :..|.|.:: .|.
Human   435 QGLVEGQSYRFRVRAISRVGSSVPSKASELVVMGDHDAARRKTEIPFDLGNKITISTDAFE-DTV 498

  Fly   785 TISS-------FENGTALLQIA--------------SVERSDIGNFT---------------CIV 813
            ||.|       .|...|.:.:|              |:|:|.||:.|               .::
Human   499 TIPSPPTNVHASEIREAYVVLAWEEPSPRDRAPLTYSLEKSVIGSGTWEAISSESPVRSPRFAVL 563

  Fly   814 D--------------NQRG---------------------APAAQNVLLVVQTAPEIDHSP---- 839
            |              ||.|                     .||........||:..:...|
Human   564 DLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQTSVSLTWDPVKDP 628

  Fly   840 ---GFTRYAARLG-------------------------------VRAQ---------------LI 855
               |:..|:.::|                               ||:.               .:
Human   629 ELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVGESSAATEPIRV 693

  Fly   856 CRSLASPQPSF--------------IW----RRHGKDLKMQRRNKFKSVERQVDALNFE----SA 898
            .::||:|...:              .|    ||.|..:.....::..|.|....|:|.:    ..
Human   694 KQALATPSAPYGFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPTRV 758

  Fly   899 LLIENTSPDDYGQYECVVRNSLGQASTTLEFSKPS-----------RPDAPLQLRVGNVSDTGVD 952
            ..:.:.....:.::.....|..|..    |.|.||           :|..|..:|...|..|.:.
Human   759 CKVSDLHEGHFYEFRARAANWAGVG----ELSAPSSLFECKEWTMPQPGPPYDVRASEVRATSLV 819

  Fly   953 LNWTPG--FDGGMQTYFRLRLKQHGEDKYKYVDAKP-GHQNISLDGLKPGATYYFSVMAANEAG- 1013
            |.|.|.  ...|..|.:.:..::.|.:::|.|...| ...::.:..|:||.:|.|.|.|.|.||
Human   820 LQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISGTHLRVSDLQPGKSYVFQVQAMNSAGL 884

  Fly  1014 GSKFMPDIKLTLSKGSQPHSAEYTEKDELPNVMIIGITSAAMVLLVLNAALVAWFVIRRQNKSQS 1078
            |...||...:.|......|..|            :|:.....:.|...|               .
Human   885 GQPSMPTDPVLLEDKPGAHEIE------------VGVDEEGFIYLAFEA---------------P 922

  Fly  1079 EAEPSNDDVYSKDDSQSVYKLPITALQADVQKKAAASTYLVENVDIIQSTAYPPKYQESSMCTPP 1143
            ||..|::..:|||     ||.|:...:..::.|...|..:::...:.....|      |.:.|..
Human   923 EAPDSSEFQWSKD-----YKGPLDPQRVKIEDKVNKSKVILKEPGLEDLGTY------SVIVTDA 976

  Fly  1144 YPLCNPDFTRT---LPNPKR--HSQRNSATGMIEGMQMRSKDDHMLISNG-----LYIPSPSPAS 1198
            ....:...|.|   |...|:  |..||....:|.|..:.      ::..|     |.:...|||:
Human   977 DEDISASHTLTEEELEKLKKLSHEIRNPVIKLISGWNID------ILERGEVRLWLEVEKLSPAA 1035

  Fly  1199 SLVI---KGSYISSPS 1211
            .|.:   .....|||:
Human  1036 ELHLIFNNKEIFSSPN 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653	22/78 (28%)
		Ig	266..327	CDD:299845	17/60 (28%)
		IG_like	357..>414	CDD:214653	5/61 (8%)
		Ig	360..427	CDD:299845	5/71 (7%)
		Ig	<468..526	CDD:299845	22/85 (26%)
		I-set	547..633	CDD:254352	15/86 (17%)
		Ig	556..631	CDD:299845	14/75 (19%)
		I-set	644..735	CDD:254352	19/103 (18%)
		IGc2	668..725	CDD:197706	7/58 (12%)
		IG_like	751..829	CDD:214653	29/157 (18%)
		IGc2	753..815	CDD:197706	22/117 (19%)
		Ig	852..928	CDD:143165	13/112 (12%)
		FN3	935..1017	CDD:238020	25/85 (29%)
MYOM3	NP_689585.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		9/34 (26%)
		I-set	154..247	CDD:254352	26/120 (22%)
		Ig	171..244	CDD:143165	22/75 (29%)
		IG_like	278..362	CDD:214653	19/109 (17%)
		Ig	<291..355	CDD:299845	14/86 (16%)
		FN3	373..463	CDD:238020	23/104 (22%)
		FN3	501..593	CDD:238020	14/91 (15%)
		FN3	603..691	CDD:238020	10/87 (11%)
		FN3	700..790	CDD:238020	14/93 (15%)
		FN3	802..891	CDD:238020	26/88 (30%)
		IG_like	1125..1205	CDD:214653
		Ig	1334..1424	CDD:299845
		I-set	1341..1424	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000