DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and Mybpc1

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_006513108.1	Gene:	Mybpc1 / 109272	MGIID:	1336213	Length:	1196	Species:	Mus musculus

Alignment Length:	1111	Identity:	213/1111 - (19%)
Similarity:	364/1111 - (32%)	Gaps:	313/1111 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 DAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIAENANPAAE 177
            |:|:.....||.|....:.||...:    |::.:| ..:...|:|...........||:......
Mouse    58 DSEWSLGESPAGGEEQDKQNANSQL----STLFVE-KPQTGSVKVGANITFVAKVRAEDLLRKPT 117

  Fly   178 IVWFQGEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPR----------AEDDYK-EFSCEARHKAL 231
            :.||:|:       .:.:...|.|......|...|.|          |:::|. .:.||..:|..
Mouse   118 VKWFKGK-------WMDLASKAGKHLQLKETFERQTRVYTFEMQIIKAKENYAGNYRCEVTYKDK 175

  Fly   232 PPDVPMRAQVQLSVLYPPGAPFFEGYSQ-GETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISS 295
            ........:|..|....|.......:.: ||    |||           ...:|.:
Mouse   176 FDSCSFDLEVHESTGTTPNIDIRSAFKRSGE----GQE-----------DAGELDF--------- 216

  Fly   296 PQRTSGRLSE------------NVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKD 348
                ||.|..            :|::....|..|....:.....:   |.||..|..  |...:.
Mouse   217 ----SGLLKRREVKQQEEEPEIDVWELLKNANPNEYEKIAFQYGI---TDLRGMLKR--LKRMRR 272

  Fly   349 VYLSGANQAKVGDSV-------QLSCVTAPSNPQARISWSINGRPLDNST-YKTTSSSDGGWVSS 405
            |....|..||:.|..       ::..|...::|:..:.|..||:.:..|| |......:...:..
Mouse   273 VEKKSAAFAKILDPAYQVDKGGKVRFVVELADPKLEVKWFKNGQEIRPSTKYIFEHKGNERIMFI 337

  Fly   406 SNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPSPPLLT--GYNDGDILISGSI-LK 467
            :|.|||.||:... .|.....:||             |:...||::.  ...|.:......: ::
Mouse   338 NNCSLTDDSEYYV-TAGDEKCSTE-------------LFVREPPIMVTKQLEDMNAYCGERVEME 388

  Fly   468 LQCSSAGGNPPPTLQWYKN-DKIINAPSKLVDSKI----------------TSELSLLVNASDNN 515
            ::.|....|    ::|:|| ::|...|......|:                ::|.|.:.....::
Mouse   389 VEVSEDDAN----VKWFKNGEEIFPGPKSRYKIKVEGKKHTLIIEGATKADSAEYSAMTTGGQSS 449

  Fly   516 AIYKCKVQNAAIDI-PLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWW 579
            |       ..::|: ||..|..|    ..:|||:         |....|.|: .|.|.|.|  |.
Mouse   450 A-------KLSVDLRPLKITTPL----TDQTVKL---------GKEVCLKCE-ISENVPGK--WT 491

  Fly   580 KDGIPV---EGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDIL 641
            |:|:||   |.|.:.::     |.:..|.:...:.:|....|:|..::|..|...||      ::
Mouse   492 KNGLPVQEGERLKVVHK-----GRIHKLVIANALIEDEGEYVFTPDAYNVPLSAKVH------VI 545

  Fly   642 YPPKF---ETPQSTTFVGVEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQ---RLISDG 700
            .|||.   ......|...:.|:...:|:..:|.|.. ...|::....|...  ||:   ....|.
Mouse   546 DPPKIILDGLDADNTVTVIAGSKLRLEIPVTGEPPP-KAIWSRADKAIMEG--SGRIRAESYPDS 607

  Fly   701 PRLNISRLSRNDAGVYICEALNSQGTALLEIQVAV------EYAPTITAVSEGRSFVAGEP---- 755
            ..|.|....|:|:|||.....|..|.|...|::.|      ..||.:|.|.:....:..||
Mouse   608 STLVIDVAERDDSGVYNINLKNEAGEAHASIKIKVVDIPDPPVAPNVTEVGDDWCIMNWEPPAYD 672

  Fly   756 ---AVLACHIQARPLEAAHVRWSRDGYDLATRTISSFE-----NGTA------------------ 794
               .:|...|:.:..:::  ||.|..:||...|  :||     .|.|
Mouse   673 GGSPILGYFIERKKKQSS--RWMRLNFDLCKET--TFEPKKMIEGVAYEVRIFAVNAIGISKPSM 733

  Fly   795 ---------------LLQIASVERSDI-------------------------GNFTCIVDNQRGA 819
                           ||.:.||..|.:                         |:.:....|:.|.
Mouse   734 PSKPFVPLAVTSPPTLLAVDSVTDSSVTMKWRPPDQIGAAGLDGYVLEYCFEGSTSAKQSNENGE 798

  Fly   820 PAAQ---------NVLLVVQTAPEIDHSPG----FTR---------------------------- 843
            .|..         |..|:.:|...|:..|.    |.|
Mouse   799 TACDLPAEDWIVANTDLIDKTKFTINGLPTDAKIFVRVKAINAAGASEPKYYSQPILVKEIIEPP 863

  Fly   844 -----------YAARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFE- 896
                       |..|:|....|:......|:|...|::.|:::.          :.|::..|.|
Mouse   864 KIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGEEID----------KNQINIRNSET 918

  Fly   897 -SALLIENTSPDDYGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFD 960
             :.:.|........|:|:..|:......:.:::.....||..|..:.:.:|....|.|.|||..|
Mouse   919 DTIIFIRKAERSHSGKYDLQVKVDKYVENASIDIQIVDRPGPPQTVTIEDVWGENVALTWTPPKD 983

  Fly   961 GGMQTYFRLRLKQHGEDKYKYVDAKPGHQ--NISLDGLKPGATYYFSVMAANEAGGSKFMPDIKL 1023
            .|........:::..:...::......:.  |.::..|..|..|||.|.|.|..|.|:     ..
Mouse   984 DGNAAITGYTIQKADKKSMEWFTVIEHYHRTNATITELVIGNEYYFRVFAENMCGLSE-----DA 1043

  Fly  1024 TLSKGS 1029
            |::|.|
Mouse  1044 TMTKES 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	2/8 (25%)
		IG_like	45..137	CDD:214653	7/23 (30%)
		Ig	153..231	CDD:299845	17/88 (19%)
		IG_like	258..342	CDD:214653	16/96 (17%)
		Ig	266..327	CDD:299845	10/72 (14%)
		IG_like	357..>414	CDD:214653	15/64 (23%)
		Ig	360..427	CDD:299845	16/74 (22%)
		Ig	<468..526	CDD:299845	11/74 (15%)
		I-set	547..633	CDD:254352	22/88 (25%)
		Ig	556..631	CDD:299845	21/77 (27%)
		I-set	644..735	CDD:254352	23/96 (24%)
		IGc2	668..725	CDD:197706	15/59 (25%)
		IG_like	751..829	CDD:214653	25/156 (16%)
		IGc2	753..815	CDD:197706	20/131 (15%)
		Ig	852..928	CDD:143165	12/77 (16%)
		FN3	935..1017	CDD:238020	21/83 (25%)
Mybpc1	XP_006513108.1	IG_like	90..185	CDD:214653	17/101 (17%)
		THB	235..268	CDD:375788	7/37 (19%)
		Ig	280..363	CDD:386229	21/96 (22%)
		Ig	370..454	CDD:386229	12/94 (13%)
		Ig	460..530	CDD:386229	23/90 (26%)
		Ig_C5_MyBP-C	557..642	CDD:143302	21/87 (24%)
		FN3	646..735	CDD:238020	18/92 (20%)
		FN3	745..847	CDD:238020	16/101 (16%)
		Ig	882..>940	CDD:386229	11/67 (16%)
		FN3	958..1041	CDD:238020	20/82 (24%)
		I-set	1073..1162	CDD:369462
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000