DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and kirrel3

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_031761736.1	Gene:	kirrel3 / 105947809	XenbaseID:	XB-GENE-922296	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	953	Identity:	218/953 - (22%)
Similarity:	342/953 - (35%)	Gaps:	279/953 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQI 105
            |...|.|..::.|....|.|.:....|.:.|.|||.|:|....:.|:|||||..|.....::|.|
Frog    46 FTQQPQDQVVVAGQPVSLLCAIPGYHGLLLWIKDGLAIGVGRDLSGYPRYSVGGDHLSGEHHLMI 110

  Fly   106 KNATLEDDAEYQCQVGPAAGNPAIRAN-AKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIA 169
            :.|.|:|||.|:||    |...|||:. |:|:::..|...||.|   ...:.:.....|.|.|.|
Frog   111 QRAELQDDAMYECQ----AIQAAIRSRPARLTVLVPPDDPVITG---GPVISIRAGDPLNLTCHA 168

  Fly   170 ENANPAAEIVWFQ-GEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPP 233
            :||.|||.|.|.: |||........|:.:.. ||.:..|||.:.....::.:..:|.|.:||:|.
Frog   169 DNAKPAATITWMKNGEVLNGATYYKTLLRDG-KRESIISTLFVSSSDIENGQTITCRATNKAVPG 232

  Fly   234 DVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQR 298
            .  ..|.|.:::.:|                               |...||        ..||.
Frog   233 G--KEATVTINIQHP-------------------------------PLVNLT--------VEPQP 256

  Fly   299 TSGRLSENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDSV 363
            .   |.:||.||..||:.|
Frog   257 V---LEDNVVKFHCAAKAN---------------------------------------------- 272

  Fly   364 QLSCVTAPSNPQARISWSING---RPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHA 425
                   |:..|.|  |:..|   :.:.:.||:|                .:|....|....|..
Frog   273 -------PAVTQYR--WAKGGQILKEVTDETYET----------------VVDFSFFTEPVSCEV 312

  Fly   426 LNTELTQNVVGSHTVNVLYPP----SPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYKN 486
            .|...:.||  |.||:|.:.|    .|..:|       :..||.....|:.. |||..|:.|.|.
Frog   313 TNALGSTNV--SRTVDVYFGPRMSSEPESIT-------VDLGSDATFHCAWI-GNPSLTIVWMKR 367

  Fly   487 DKIINAPSKLVDSKITSELSL-LVNASDNNA-IYKC-----KVQNAAIDIPLFATKTLGVHFPPE 544
            .      |.:|   :::|.:| |.|....:| .|.|     :|.....||      :|.|:.||
Frog   368 G------SGVV---LSNENTLTLKNVRQEDAGKYVCRAVVPRVGAGERDI------SLTVNGPP- 416

  Fly   545 TVKISVVPKNLVPGIRAKLICDSSSSNPPAKISW-WKDGIPVEGLNLANRPGLW--------GGS 600
             :..|...::.:.|.:.::.|...|:.||.:|:| ||:.:...|.:     |.:        .|.
Frog   417 -IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTS-----GRYTVETVSTDEGV 475

  Fly   601 VSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFET-----PQS---TTFVGV 657
            :|||.:...:..|.. .:|.|.:.|..  .|..|.|.|. ...|..::     |:|   |..:||
Frog   476 ISTLTISNIVRADFQ-TIYNCTAWNSF--GSDTEIIRLK-EQGPNMQSGTSMEPESVPVTVIIGV 536

  Fly   658 ---EGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICE 719
               .|..|.| |:|:    ::.:...:     :..:|.|  ::|          ::||..|.|..
Frog   537 AVGAGVAFLV-LMAT----IVAFCCAR-----NQRNLKG--VVS----------AKNDIRVEIVH 579

  Fly   720 ALNSQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHI-QARPLEAAHVRWSRDGY---- 779
            ...|.|.       ..|...||..:...|.....:..:....: :....|..:::...:||
Frog   580 KEPSTGR-------ETEDHSTIKQLMIDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVN 637

  Fly   780 ---DLATRTISSFENGTALLQIASVERSDIG-NFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPG 840
               |.:|.|| |..|....|:.|:.:|...| :||.|.....|    ||.|        .|:|
Frog   638 TFKDHSTPTI-SLSNCQQDLRPANKQRVPTGMSFTNIYSTLSG----QNRL--------YDYS-- 687

  Fly   841 FTRYAARLGVRAQLIC-----RSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALL 900
             .|:...:|..:..:|     |...|...||:                   :.|.|:....|.
Frog   688 -QRFVLGMGSSSIELCEREFQRGSMSDSSSFL-------------------DTQCDSSVSSSG-- 730

  Fly   901 IENTSPDDYGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRV 943
                ..|.|.|::...:.|...:..:...|:.|.|..|||.|:
Frog   731 ----KQDGYVQFDKSSKASASSSHYSQSSSQNSDPSKPLQRRM 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	29/77 (38%)
		IG_like	45..137	CDD:214653	35/92 (38%)
		Ig	153..231	CDD:299845	23/78 (29%)
		IG_like	258..342	CDD:214653	13/83 (16%)
		Ig	266..327	CDD:299845	13/60 (22%)
		IG_like	357..>414	CDD:214653	8/59 (14%)
		Ig	360..427	CDD:299845	11/69 (16%)
		Ig	<468..526	CDD:299845	17/64 (27%)
		I-set	547..633	CDD:254352	21/94 (22%)
		Ig	556..631	CDD:299845	19/83 (23%)
		I-set	644..735	CDD:254352	20/101 (20%)
		IGc2	668..725	CDD:197706	9/56 (16%)
		IG_like	751..829	CDD:214653	20/86 (23%)
		IGc2	753..815	CDD:197706	16/70 (23%)
		Ig	852..928	CDD:143165	12/80 (15%)
		FN3	935..1017	CDD:238020	5/9 (56%)
kirrel3	XP_031761736.1	IG	50..139	CDD:214652	35/92 (38%)
		IgI_2_KIRREL3-like	145..242	CDD:409416	30/102 (29%)
		Ig strand B	162..166	CDD:409416	2/3 (67%)
		Ig strand C	176..180	CDD:409416	1/3 (33%)
		Ig strand E	206..210	CDD:409416	3/3 (100%)
		Ig strand F	220..225	CDD:409416	1/4 (25%)
		Ig strand G	235..238	CDD:409416	1/2 (50%)
		Ig	331..412	CDD:416386	25/103 (24%)
		Ig strand A'	339..343	CDD:409353	1/10 (10%)
		Ig strand B	346..356	CDD:409353	2/10 (20%)
		Ig strand C	361..367	CDD:409353	2/5 (40%)
		Ig strand E	377..383	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	414..511	CDD:409479	25/106 (24%)
		Ig strand B	432..436	CDD:409479	0/3 (0%)
		Ig strand C	446..450	CDD:409479	1/3 (33%)
		Ig strand E	477..481	CDD:409479	3/3 (100%)
		Ig strand F	492..497	CDD:409479	2/4 (50%)
		Ig strand G	505..508	CDD:409479	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010