DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and kirrel2

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001135598.1	Gene:	kirrel2 / 100216155	XenbaseID:	XB-GENE-854070	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	884	Identity:	196/884 - (22%)
Similarity:	309/884 - (34%)	Gaps:	230/884 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQI 105
            |...|.|..|:.|....|.|.|....|.||||.||.|||....:||:.||||:.|.....:||.|
Frog    24 FSQQPSDKVIVAGKSVTLPCVVIGYRGVVQWTMDGLALGAERDLPGWSRYSVVGDPSLGEHNLHI 88

  Fly   106 KNATLEDDAEYQCQVGPAAGNPAIRA-NAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIA 169
            :...|.|||.|:||    |...|:|: .|:|:::..|...:|.| :..|.|.:....|||  |:|
Frog    89 EGVELSDDAIYECQ----ATQAALRSQRARLTVLLPPGDPMIPG-SPVANVLLNVPYNLT--CLA 146

  Fly   170 ENANPAAEIVWFQGEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPPD 234
            ..|.|||||.|::....:.:|.......:..|...::|:|.:.|...|....::|..|::|||..
Frog   147 PVAKPAAEITWYRDGKKLDSAVYTKELLSDGKSEGSASSLLITPSLADSGSSYTCRVRNEALPEG 211

  Fly   235 VPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQRT 299
              ....|.|||.|||....   ..:..|:..|..|...|.:..........|.:.||    |...
Frog   212 --REKSVTLSVQYPPKVTL---SVEPPTITEGGSVTFLCGAVSNPEVTGYRWAKGGV----PLAV 267

  Fly   300 SGRLSENVYKFTAAAEDN--GANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDS 362
            ||.      |:|...:..  .|.:.||..|.:..:.:...:|  ||:.|:.:.........:||.
Frog   268 SGD------KYTVEVDHTFFTAPVSCEVSNSVGASNVSTAVN--VLFGPRLLTEPRPMTVDIGDD 324

  Fly   363 VQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSN-ISLTIDSQSRTFIAVCHAL 426
            ....|           .|:.|..|....:.|.|    |..:|:.| :.||..::....|.||.|:
Frog   325 ASFFC-----------GWTGNPTPTQFWSKKGT----GEVLSNGNTLLLTKVTREDAGIYVCKAI 374

  Fly   427 -------NTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWY 484
                   ..|:|..|.|           ||::|.....:..:.|. .:::|.......|..:.|.
Frog   375 VPRMGSTEKEVTLTVRG-----------PPIITSEMHYETTLGGK-ARMECLIESTPAPDRIVWA 427

  Fly   485 KNDKIINAPS---KLVDSKIT--SELSLLV----NASDNNAIYKCKV--------------QNAA 526
            .:.:.:...|   ..|::::|  ..:|:||    ..||....:.|..              |.||
Frog   428 WDKQSLEDGSWGRFSVETEVTEVGAISVLVIDGAEQSDFLTEFNCSAINQYGEDSVIVSLRQQAA 492

  Fly   527 IDIPLF---------------ATKTLGVHFPPETVKISVV--------------PKNLVPGIRAK 562
            :.:.|.               .|..|....|.:.||.:.:              |.:....::..
Frog   493 LPLTLLLIAVGSGTLCIFVLVITSILCCRRPKKAVKDTQILAVDVSGSEPSERHPSDSEEDLKEP 557

  Fly   563 LICDSSSSNPPAKISWWKDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEV 627
            |..|:.|....          ..|..::.:.|                 ||.....|..::|
Frog   558 LHTDTESQRTS----------QTEHSDIPDEP-----------------QDPTNGYYKVRAH--- 592

  Fly   628 LQRSVHETISLDILYPPKFETP----QSTTFVGVEGAPFHVELLASGNPMVITY-----TWTKDG 683
                 .:|....|.| |:|.:|    .|||.......|     ..||.|.:..|     |..:.|
Frog   593 -----EDTRPTTITY-PEFSSPPRPLYSTTSSLSPLCP-----TPSGPPKIYDYAHRYATTPRSG 646

  Fly   684 ---LPISSNS--LSGQRLISDGPRLNISRLSRNDAGVYICEALNSQGTALLEIQVAVEYAPTI-- 741
               :|..|:|  ..|...:..||                        ..|.::...:..|||.
Frog   647 GHHMPQGSSSHLPQGTTHLPQGP------------------------MHLPQVPTHLPQAPTYLP 687

  Fly   742 ---TAVSEGRSFVAGEPAVL---ACHIQ-------------ARPLEAAHVRWSR-DGYDLATRTI 786
               |.:.:|.:.:...|..|   ..|:|             :.|...|...:.| |.:|
Frog   688 QGPTHLPQGPTHLPQGPTHLPHGPSHLQQGLSHLPPGPSQHSAPYARAFCSYVRPDRFD------ 746

  Fly   787 SSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNV 825
             |.:.|.||.:::....:...:|        |.|:.|.:
Frog   747 -SMDQGPALARLSYASLTTHSDF--------GRPSQQRM 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	34/77 (44%)
		IG_like	45..137	CDD:214653	39/92 (42%)
		Ig	153..231	CDD:299845	22/77 (29%)
		IG_like	258..342	CDD:214653	17/85 (20%)
		Ig	266..327	CDD:299845	14/62 (23%)
		IG_like	357..>414	CDD:214653	13/57 (23%)
		Ig	360..427	CDD:299845	17/74 (23%)
		Ig	<468..526	CDD:299845	13/80 (16%)
		I-set	547..633	CDD:254352	11/99 (11%)
		Ig	556..631	CDD:299845	9/74 (12%)
		I-set	644..735	CDD:254352	20/104 (19%)
		IGc2	668..725	CDD:197706	12/66 (18%)
		IG_like	751..829	CDD:214653	17/92 (18%)
		IGc2	753..815	CDD:197706	14/78 (18%)
		Ig	852..928	CDD:143165
		FN3	935..1017	CDD:238020
kirrel2	NP_001135598.1	IG_like	28..117	CDD:214653	39/92 (42%)
		Ig2_KIRREL3-like	139..220	CDD:143236	25/84 (30%)
		Ig_2	225..294	CDD:372793	16/81 (20%)
		Ig	308..389	CDD:386229	20/95 (21%)
		Ig	391..488	CDD:386229	17/108 (16%)
		Atrophin-1	529..>765	CDD:367360	51/307 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010