DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hbs and kirrel1b

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_017212964.1	Gene:	kirrel1b / 100170816	ZFINID:	ZDB-GENE-070912-173	Length:	801	Species:	Danio rerio

Alignment Length:	646	Identity:	164/646 - (25%)
Similarity:	249/646 - (38%)	Gaps:	181/646 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQFWITLTFAVHLATTICHVMAAVTAPTPAAQVAAPPVQKFHLTPHDLQILEGTDTLLRCEVSNR 65
            |.|.:|..:.|.||....|            :|.:.|  :|...|.|..::.|...:|.|.|.|.
Zfish     1 MGFSMTCLWIVTLAIISVH------------RVFSGP--RFSQEPADQSVVIGERVVLSCVVFNY 51

  Fly    66 AGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIR 130
            .|.|||||||.|||....:..:|||.||.......|||:|.:|.|.||:.|:||    |...|:|
Zfish    52 TGIVQWTKDGLALGIGEDLRAWPRYRVLRIMDVGQYNLEITSADLTDDSLYECQ----ATEAALR 112

  Fly   131 A-NAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIAENANPAAEIVWFQGEVPVSTAPIVT 194
            : .|||:::..|...||||   :..:.:....:..|.|::..|.|.:.|.|::..:.|..|...|
Zfish   113 SRRAKLTVLIPPDGPVIEG---SPEILLTAGTSFNLTCVSRGAKPMSTIEWYKDGIIVEGAHTST 174

  Fly   195 VNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQ 259
            ...:..||.||.|.|.:||...|..:.|:|.|.:.|.|  :..|:.|.|::.:||....   ..:
Zfish   175 EVLSDRKRVTTKSFLEIQPMDTDTGRNFTCVASNLAAP--LGKRSTVTLNIHHPPTVIL---SIE 234

  Fly   260 GETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVYKFTAAAEDNGANLVCE 324
            ..::..|:.|:..|::....|.....|.:.||.:...:       |:|::.|
Zfish   235 PRSVLEGERVKFTCQATANPPIMGYRWAKGGVILDGAR-------ESVFETT------------- 279

  Fly   325 AKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSCVTAPSNPQARISWSINGRPLDN 389
            |.:...|.|                               :||:...:
Zfish   280 ADHSFFTEP-------------------------------VSCLVFNA----------------- 296

  Fly   390 STYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPSPPLLTGY 454
                         |.|:|:|:.:|......:.|                      .|.|  :|..
Zfish   297 -------------VGSTNVSILVDVHFGPILVV----------------------EPRP--VTVD 324

  Fly   455 NDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKIINAPSKLVDSKITSELSLLVNASDNNAIYK 519
            .|.|:       .|.|..: ||||.||.|.|..      |.:|.|. :::|.|...:..:...|.
Zfish   325 VDSDV-------TLNCKWS-GNPPLTLTWTKKG------SSMVLSN-SNQLFLKSVSQADAGQYV 374

  Fly   520 CKVQNAAIDIPLFAT----KTLGVHFPPETVKISVVP-KNLVPGIRAKLICDSSSSNPPAKISW- 578
            ||    || :|....    .||.|:.||   .||..| :..|.|.:.::.|..:|:.||.||.|
Zfish   375 CK----AI-VPRIGVGETEVTLTVNGPP---IISSEPIQYAVRGEKGEIKCYIASTPPPDKIVWA 431

  Fly   579 WKDGI------------PVEGLNLANRPGLWGGSV-STLEMYVNITQDLD-GIVYTCQSHN 625
            ||:.:            .||    .:||...||:| |||.  :|...:.| ...|.|.:.|
Zfish   432 WKENVWEKERGTLLERYTVE----QSRPATQGGAVLSTLT--INNVMEADFQSTYNCTAWN 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	34/77 (44%)
		IG_like	45..137	CDD:214653	40/92 (43%)
		Ig	153..231	CDD:299845	21/77 (27%)
		IG_like	258..342	CDD:214653	13/83 (16%)
		Ig	266..327	CDD:299845	11/60 (18%)
		IG_like	357..>414	CDD:214653	6/56 (11%)
		Ig	360..427	CDD:299845	8/66 (12%)
		Ig	<468..526	CDD:299845	18/57 (32%)
		I-set	547..633	CDD:254352	29/95 (31%)
		Ig	556..631	CDD:299845	26/85 (31%)
		I-set	644..735	CDD:254352
		IGc2	668..725	CDD:197706
		IG_like	751..829	CDD:214653
		IGc2	753..815	CDD:197706
		Ig	852..928	CDD:143165
		FN3	935..1017	CDD:238020
kirrel1b	XP_017212964.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920