DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hbs and si:ch211-180a12.2

DIOPT Version :9

Sequence 1:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_001920945.3	Gene:	si:ch211-180a12.2 / 100150385	ZFINID:	ZDB-GENE-121214-236	Length:	903	Species:	Danio rerio

Alignment Length:	1041	Identity:	206/1041 - (19%)
Similarity:	338/1041 - (32%)	Gaps:	296/1041 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLQILEGTDTLLRCE------VSNRAGKVQWTKDGFAL--------GF---SAVIPGFPRYSVLV 94
            |:.:..|:.|:|.|.      |.|....:.|:..|..:        ||   |...|.||
Zfish    22 DVSVSPGSSTVLNCSFALPALVDNSLLNITWSSGGSIIASKNHTQAGFFLNSTAFPSFP------ 80

  Fly    95 DAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEE 159
                    |.:.|||......|:|:|  :..:........|:|:|.|...:|...|...|..|.|
Zfish    81 --------LTVFNATPHQQGVYECRV--SYNDTDYATEVTLTILAPPVVSIISPEAVLKRKSVVE 135

  Fly   160 RQNLTLHCIAEN-ANPAAEIVWFQGEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDDYKEFS 223
                   |.|.: :.|.....|.:|...:.....:.||:|....:...|.|...|:..:....|.
Zfish   136 -------CWARSFSPPQIMFTWTRGGNKIQEPQKLQVNRTEDGLYDAVSFLTFIPQISNQNISFG 193

  Fly   224 CEARHKAL--------PPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNP 280
            ||.:|.||        .|.:.:..:|.|||:  |.:            .....|.::|...|..|
Zfish   194 CEVQHSALVKPVLEEFTPHITVLPKVTLSVV--PSS------------SHSSSVTLSCDISGFYP 244

  Fly   281 -PAQLTWYRNGVAIS----SPQRTSGRLSENVY-KFTAAAEDNGANLVCEAKNLLATTPLRAELN 339
             ...:.|..||..:|    |.|...|....:.| ..|......|..:.|
Zfish   245 NNISVLWIHNGKKLSELPLSIQNEDGTYRRHQYHTLTREERSRGGEVQC---------------- 293

  Fly   340 LTVLYAPKDVYLSGANQAKVGDSVQLSCV-TAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWV 403
                     |.|..:.|.....::.||.| ....||      .:|         |:..:|    |
Zfish   294 ---------VALQPSGQEPANGTIDLSTVDLRVQNP------GLN---------KSAKAS----V 330

  Fly   404 SSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILKL 468
            :...||||:     .|: :|...:.:.....:.|..::.:..| |.::.| ..|.:.|
Zfish   331 AMMIISLTL-----VFL-LCFGFSWKRRDEKLKSLNISAIVLP-PRVVVG-KKGRVTI------- 380

  Fly   469 QCSSAGGNPPPTLQ--WYKNDKIINAPSKLVDSKITSELSLLVNASDNNAIYKCKVQNAAIDIPL 531
               |..|.....:|  |:.||         :..|.||.......|. .:|.|..:  |:::.:
Zfish   381 ---SVEGRLAERVQTTWFLND---------IPIKDTSHKEKKYGAF-RSASYTSR--NSSVSV-- 428

  Fly   532 FATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNP--PAKISWWKDGIPVEGLNLANRP 594
                                               .|..||  |:..|.:        ..|..:.
Zfish   429 -----------------------------------LSEKNPLLPSSASGY--------YKLHTQM 450

  Fly   595 GLWGGSVSTLEMYVNIT--QDL---DGIVYTCQSHNEVLQRSVHETIS--LDILYPP-----KFE 647
            .|...|.|:.:::.::|  ..|   .|.|:.||...:...:.|.|.:|  ..||.||     :|.
Zfish   451 PLRSSSNSSKQLFSSVTFIPSLAVHKGSVFKCQVSYKGKDKIVAERVSEKFTILAPPEVSEIQFS 515

  Fly   648 TPQSTTFVGVEGAPFHVELLASG-NPMVITYTWTKDGLPISSNSLSGQRLISDGP---------- 701
            .|..      ||....:...||. :|.:||:.|..:|..:|..|:. |.|.:..|
Zfish   516 EPNE------EGGVVTMTAHASHFHPDIITFRWFCEGGELSPVSIP-QALAAPRPDAEGFFSAMS 573

  Fly   702 --RLNISRLSRNDAGVYIC---EALNSQGTA-----LLEIQVAVEYAPTITAVSEGRSFVAGEPA 756
              ||..:.|.|.:..|::.   .||....|.     :.:..::...:..:.:|.|||       .
Zfish   574 QCRLPKAELERGETRVWVTIHHTALKQPITRQTRGFIKQPSISEILSCPVASVLEGR-------L 631

  Fly   757 VLACHIQARPLEAAHVRW-----------------SRDGYDL--ATRTISSFENGTALLQIASVE 802
            .|||.|.........|:|                 .:||.::  ..:|:.......|||:..: |
Zfish   632 TLACEITGFYPPEISVKWLHSKGNEIEDGDDSEEEIKDGAEVWGPLQTLPRTFRAKALLKDVN-E 695

  Fly   803 RSDIGNFTCIVDNQRGAPAAQNVLLVVQT-APEIDHSPGFTRYAARLGVRAQLICRSLASPQPSF 866
            .:..|...|.|.:.........|.....| ||.|..|......:..:|:.:.::|.  ..|....
Zfish   696 MTRGGQIICRVSHCCLLKPVDRVWRNTHTVAPSIPPSLSVHWSSDGVGIFSIVLCG--GRPSAEV 758

  Fly   867 IWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYECVVRNSLGQASTTLEFSK 931
            :|...|..|     ::.:|.||:.:  |.|..|.:::.         |.:..|.|:..:......
Zfish   759 LWAAGGSTL-----SRLQSKERERE--NNEGKLELKSV---------CALVRSTGRKDSESRRGT 807

  Fly   932 PSRPDAPLQLRVGNVSDTGVDLNW-----TPGFDG--GMQTYFRLRLKQHGEDKYKYVDAKPGHQ 989
            .:|...|          ..||.|.     ....||  .:|...:....:|.::..:..|..|.|.
Zfish   808 HARKIRP----------PSVDFNTDYEKVNECVDGLKSVQEEKQPEPNKHTKENDENEDMHPSHV 862

  Fly   990 N 990
            |
Zfish   863 N 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hbs	NP_001286439.1	Ig	44..122	CDD:299845	22/91 (24%)
		IG_like	45..137	CDD:214653	23/106 (22%)
		Ig	153..231	CDD:299845	18/78 (23%)
		IG_like	258..342	CDD:214653	15/89 (17%)
		Ig	266..327	CDD:299845	15/66 (23%)
		IG_like	357..>414	CDD:214653	13/57 (23%)
		Ig	360..427	CDD:299845	15/67 (22%)
		Ig	<468..526	CDD:299845	13/59 (22%)
		I-set	547..633	CDD:254352	15/92 (16%)
		Ig	556..631	CDD:299845	15/81 (19%)
		I-set	644..735	CDD:254352	25/116 (22%)
		IGc2	668..725	CDD:197706	19/72 (26%)
		IG_like	751..829	CDD:214653	17/96 (18%)
		IGc2	753..815	CDD:197706	16/80 (20%)
		Ig	852..928	CDD:143165	14/75 (19%)
		FN3	935..1017	CDD:238020	12/63 (19%)
si:ch211-180a12.2	XP_001920945.3	Ig	19..114	CDD:299845	23/107 (21%)
		IG_like	22..113	CDD:214653	23/106 (22%)
		C1-set	123..205	CDD:284964	21/88 (24%)
		IgC	237..309	CDD:143166	17/96 (18%)
		IgC	515..604	CDD:143166	22/95 (23%)
		IgC	609..720	CDD:143166	21/118 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810