DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mab-21 and MAB21L4

DIOPT Version :9

Sequence 1:	NP_651971.2	Gene:	mab-21 / 44127	FlyBaseID:	FBgn0029003	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001078906.3	Gene:	MAB21L4 / 79919	HGNCID:	26216	Length:	447	Species:	Homo sapiens

Alignment Length:	403	Identity:	84/403 - (20%)
Similarity:	148/403 - (36%)	Gaps:	74/403 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VPSDMIAAQSKMVYQMNKYCADRVQVRKAQIHKQIQEVCRIVQDVLKEVEVQEPRFISSLNDYNG 67
            :|:..:|.|..:.:    :....::.|:|...:..|....::..||:.|...:||||.   ||:
Human     6 LPTSAMAVQVPLWH----HYLQAIRSREAPRAQDFQRAENVLLTVLERVHALDPRFIV---DYS- 62

  Fly    68 RFEGLEVI--------SPTEFEIIIYLNQMGVLNFVDDGTLP--GCAVLKLSDGRK-RSMSLWV- 120
              .|||..        .|.:.|:.::::...:|....:.|.|  |..:..|...|: ..:..|.
Human    63 --RGLEAFQFALRSSEDPMDMEVPLWVDAEALLIEEPEATQPEDGLELCHLGVPREGAGLERWTT 125

  Fly   121 -EFITAS--------GYLSARKIRSRFQTLVAQACDKCAYRDIVK----MIADTTEVKLRIR--- 169
             :..|||        |::...|:....:.|:..|...|.:..::.    ..|...|.:|.:.
Human   126 EDTFTASSEGDAKCRGHIVPSKVLCVLKDLLVAAIVHCKHHSLIAPGSLNAASLREEQLHLSLLV 190

  Fly   170 ----ERIIVQITPAFKCAGLWPRSASHWPLPGIPWPHPNIVAEVKTEGFDMLSKECIALQGKNSA 230
                ..|...:.|..:.....|.......:||.|   ...:..:.::|.|::            .
Human   191 SSGWRTISFHVVPVVRRKLGAPALEGVQQMPGFP---EGSLRRILSQGVDLV------------P 240

  Fly   231 MEGDAWVLSFTDAENRL------LQGASRRRCLSILKTLRDRHLDLPG--NPVTSYHLKTLLLYE 287
            .....|..|......||      ||| .|...||||..:........|  :.:|..|||.:||:.
Human   241 ASAQLWRTSTDYLLTRLLGELGSLQG-HRLDSLSILDRVNHESWRDSGQTDGLTFGHLKMVLLWA 304

  Fly   288 CEKHPREMEWEENCIADRINGIFLQLISCLQCRRCPHYFLPNMDLFKGK--SPGAL----ENAAK 346
            ........:|.|  :...:..:.:.|:.||..|:.||:..|..:|.:|.  ..||:    |..|.
Human   305 SVLFLAPEDWAE--LQGAVYRLLVVLLCCLATRKLPHFLHPQRNLLQGSGLDLGAIYQRVEGFAS 367

  Fly   347 QVWRLTRIMLTNV 359
            |.....||..|::
Human   368 QPEAALRIHATHL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mab-21	NP_651971.2	Mab-21	68..350	CDD:397398	66/327 (20%)
MAB21L4	NP_001078906.3	Mab-21	143..363	CDD:367433	47/237 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10656
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010