DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mab-21 and Cgas

DIOPT Version :9

Sequence 1:	NP_651971.2	Gene:	mab-21 / 44127	FlyBaseID:	FBgn0029003	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	XP_038938458.1	Gene:	Cgas / 682147	RGDID:	1586939	Length:	510	Species:	Rattus norvegicus

Alignment Length:	354	Identity:	85/354 - (24%)
Similarity:	154/354 - (43%)	Gaps:	68/354 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KYCADRVQVRKAQIHKQIQEVCRIVQDVLKEVEVQEPRF--ISSLNDYNGRFEGLEVISPTEFEI 82
            |...|::::::.:|....:.|.::|..:|:.::.:|..|  :..||. ...:|.:::.:|.||::
  Rat   154 KKVLDKLRLKRKEISAAAETVNKVVDQLLRRMQRRESEFKGVEQLNT-GSYYEHVKISAPNEFDV 217

  Fly    83 IIYLN--QMGVLNFVDDGTLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQA 145
            :..|.  ::.:..:.:.|........::..|...|..|..|      .|||.|:.|:|:.|:
  Rat   218 MFKLEVPRIELEEYYETGAFYRVKFKRIPRGNPLSHFLEGE------VLSATKVLSKFRELI--- 273

  Fly   146 CDKCAYRDIVKMIADT-----------TEVKLRIR--ERIIVQITPAFKCAGLWPRSASHWPLPG 197
                  ::.||.|.||           ..|.|.||  |.|.|.|..|.:..|.||.|..    .|
  Rat   274 ------KEEVKEIKDTDVTVEEEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTK----GG 328

  Fly   198 IP---WPHPNIVAEVKTEGFDMLSKECIALQGKNSAMEGDAWVLSFTDAENRLL----------- 248
            :|   |....:...::.|.|.::.|.  |..|  :..:|:.|.|||:..|..:|
  Rat   329 LPIQDWLGTKVRTNLRREPFYLVPKN--AKDG--NRFQGETWRLSFSHTEKYILNNHGIGKTCCE 389

  Fly   249 -QGAS--RRRCLSILKTLRD------RHLDLPGNPVTSYHLKTLLLYECEKHPREMEWEENCIAD 304
             .||.  |:.||.::|.|.:      :.||    ...|||:||.:.:...|.|::.:|:...::.
  Rat   390 SSGAKCCRKECLKLMKYLLEQLKREFQELD----AFCSYHVKTAIFHMWTKDPQDSQWDPRNLST 450

  Fly   305 RINGIFLQLISCLQCRRCPHYFLPNMDLF 333
            ..:......:.||:..:..|||:|..:||
  Rat   451 CFDKFLTFFLECLRTEKLDHYFIPKFNLF 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mab-21	NP_651971.2	Mab-21	68..350	CDD:397398	75/304 (25%)
Cgas	XP_038938458.1	PHA03247	<2..143	CDD:223021
Cgas	XP_038938458.1	Mab-21	203..498	CDD:397398	75/304 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910