DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mab-21 and TMEM102

DIOPT Version :9

Sequence 1:	NP_651971.2	Gene:	mab-21 / 44127	FlyBaseID:	FBgn0029003	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001307373.1	Gene:	TMEM102 / 284114	HGNCID:	26722	Length:	508	Species:	Homo sapiens

Alignment Length:	191	Identity:	48/191 - (25%)
Similarity:	63/191 - (32%)	Gaps:	50/191 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 RERIIVQITPAFKCAGLWPRSA-SHWPLPGIPWPHPNIVAEVKTEGFDMLSKECIALQ----GKN 228
            |..::..:.|....|| ||..| ||      .|..|             |:.|..:..    |..
Human   311 RRLLLFDLIPVVSVAG-WPEGARSH------SWAGP-------------LASESASFYLVPGGGT 355

  Fly   229 SAMEGDAWVLSFTDAE--------NRLLQGASRRRCLSILKTLRDRHLDLPGNPVTSYHLKTLLL 285
            ......||.|.|...|        ..|||..:..:.|.       |.|.........|.|:|||.
Human   356 ERPCASAWQLCFARQELALKARIPAPLLQAHAAAQALL-------RPLVAGTRAAAPYLLRTLLY 413

  Fly   286 YECEKHPR-EMEWEEN----CIADRINGIFLQLISCLQCRRCPHYFLPNMDLFKGKSPGAL 341
            :.||:.|. .:...||    |:     |:..:|...|:....|||||....|..|....||
Human   414 WACERLPALYLARPENAGACCL-----GLLDELGRVLEAGTLPHYFLNGRQLRTGDDSAAL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mab-21	NP_651971.2	Mab-21	68..350	CDD:397398	48/191 (25%)
TMEM102	NP_001307373.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..231
TMEM102	NP_001307373.1	Mab-21	<317..455	CDD:308741	41/169 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3963
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10656
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910