DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mab-21 and MB21D2

DIOPT Version :9

Sequence 1:	NP_651971.2	Gene:	mab-21 / 44127	FlyBaseID:	FBgn0029003	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_848591.2	Gene:	MB21D2 / 151963	HGNCID:	30438	Length:	491	Species:	Homo sapiens

Alignment Length:	402	Identity:	91/402 - (22%)
Similarity:	160/402 - (39%)	Gaps:	91/402 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RVQVRKAQIHKQIQEVCRIVQ---DVLKEVEVQEPR-FISSL--------------NDY----NG 67
            |...|..:::|.|||..:..|   |..:.:|:...: ||.|:              |:|    .|
Human    28 RSGARVEELNKLIQEFTKHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGG 92

  Fly    68 RFEG--------LEVIS-PTEFEIIIYL----------NQMGVLNFVDDGTLPGCAVLKLSDGRK 113
            ..||        |.|.: .|::::...|          ||...|:............|:|.|  :
Human    93 VREGVVDLDLDELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFD--E 155

  Fly   114 RSMSLWVEFIT-------ASGY-LSARKIRSRFQ---TLVAQACDKCAYR---DIVKMIADTTEV 164
            .::|.|.:..|       |:.| .|..|:...|.   ::|.....|...|   .:.|:..:.|.:
Human   156 GTISKWKDCCTIVDHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGTII 220

  Fly   165 KLRI---RERIIVQITPAFKCAGLWPRSASHWPLPGIPWPHPNIVAEVKTEGFDMLSKECIALQG 226
            .:.:   ..|::..|.|.....| ||..|..|.:....| ...|..|....|| .|...| :.:|
Human   221 SIILGVGSSRMLYDIVPVVSFKG-WPAVAQSWLMENHFW-DGKITEEEVISGF-YLVPAC-SYKG 281

  Fly   227 KNSAMEGDAWVLSFTDAENRLLQGASRRRCLS--------ILKTLRDRHLDLPGNPVTSYHLKTL 283
            |    :.:.|.|||..:|.:|      ::|:|        ..|.:..:.|..| ..::.|||:::
Human   282 K----KDNEWRLSFARSEVQL------KKCISSSLMQAYQACKAIIIKLLSRP-KAISPYHLRSM 335

  Fly   284 LLYECEKHPREMEWEENCIADRINGIFLQLISCLQCRRCPHYFLPNMDLFKGKSPGALENAAKQV 348
            :|:.|::.|.....:|:..|..:.|:...|..||..:.||:||:|..::        ||:.:::.
Human   336 MLWACDRLPANYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNM--------LEHLSEET 392

  Fly   349 WRLTRIMLTNVR 360
            ..|....|::||
Human   393 VMLHARKLSSVR 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mab-21	NP_651971.2	Mab-21	68..350	CDD:397398	72/325 (22%)
MB21D2	NP_848591.2	Mab-21	176..401	CDD:308741	57/247 (23%)
MB21D2	NP_848591.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..452
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3963
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10656
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910