DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mab-21 and CGAS

DIOPT Version :9

Sequence 1:	NP_651971.2	Gene:	mab-21 / 44127	FlyBaseID:	FBgn0029003	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_612450.2	Gene:	CGAS / 115004	HGNCID:	21367	Length:	522	Species:	Homo sapiens

Alignment Length:	396	Identity:	87/396 - (21%)
Similarity:	169/396 - (42%)	Gaps:	94/396 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVPSDMIAAQSKMVYQMNKYCADRVQVRKAQIHKQIQEVCRIVQDVLKEVEVQEP-RFISSLND 64
            :||..|.....||:     :...:::::.:..|......|..:|..:|..::.... |.:..||.
Human   152 ILVRRDAAPGASKL-----RAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNT 211

  Fly    65 YNGRFEGLEVISPTEFEIIIYLNQMGVLNFVDDGTLPGCAVLKLSDGR-------KRS-----MS 117
             ...:|.:::.:|.||:::..|.            :|...:.:.|:.|       ||:     :|
Human   212 -GSYYEHVKISAPNEFDVMFKLE------------VPRIQLEEYSNTRAYYFVKFKRNPKENPLS 263

  Fly   118 LWVEFITASGYLSARKIRSRFQTLVAQACDKCAYRDIV--KMIADTTEVKLRIRERIIVQITPAF 180
            .::|    ...|||.|:.|:|:.::.:..:.....|::  :....:..|.|.|.|:|.|.||.|.
Human   264 QFLE----GEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLAL 324

  Fly   181 KCAGLWPRSASHWPLPGI---PWPHPNIVAEVKTEGFDMLSKECIALQGKNSAMEGDAWVLSFTD 242
            :....||.|...    |:   .|....:..:::.:.|.::.|.  |.:|  :..:.:.|.|||:.
Human   325 ESKSSWPASTQE----GLRIQNWLSAKVRKQLRLKPFYLVPKH--AKEG--NGFQEETWRLSFSH 381

  Fly   243 AENRLL--QGAS------------RRRCLSILKTLRD---------RHLDLPGNPVTSYHLKTLL 284
            .|..:|  .|.|            |:.||.::|.|.:         :|||    ..:|||:||..
Human   382 IEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLD----KFSSYHVKTAF 442

  Fly   285 LYECEKHPREMEWE--------ENCIADRINGIFLQLISCLQCRRCPHYFLPNMDLFKGKSPGAL 341
            .:.|.::|::.:|:        :||:.     .|||   ||:..:..:||:|..:||   |...:
Human   443 FHVCTQNPQDSQWDRKDLGLCFDNCVT-----YFLQ---CLRTEKLENYFIPEFNLF---SSNLI 496

  Fly   342 ENAAKQ 347
            :..:|:
Human   497 DKRSKE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mab-21	NP_651971.2	Mab-21	68..350	CDD:397398	75/328 (23%)
CGAS	NP_612450.2	DNA-binding. /evidence=ECO:0000269\|PubMed:28363908	1..160		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..144
		RecX	15..>117	CDD:294607
		Required for association with the cell membrane. /evidence=ECO:0000269\|PubMed:30827685	64..75
		Required for activation upon DNA viral infection. /evidence=ECO:0000269\|PubMed:28314590	120..160		3/7 (43%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:30007416, ECO:0000305\|PubMed:23707061, ECO:0007744\|PDB:6CTA	173..215		7/42 (17%)
		Mab-21	214..510	CDD:281298	75/328 (23%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:30356214	295..305		1/9 (11%)
		DNA-binding. /evidence=ECO:0000305\|PubMed:23707061	384..407		3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3963
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810