DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AstA-R1 and GALR3

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_003605.1	Gene:	GALR3 / 8484	HGNCID:	4134	Length:	368	Species:	Homo sapiens

Alignment Length:	320	Identity:	113/320 - (35%)
Similarity:	174/320 - (54%)	Gaps:	30/320 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DAESVALE---RIVSTIVPVFFGIIGFAGLLGNGLVILVVV-----ANQQMRSTTNLLIINLAVS 119
            ||::::|:   .:.:..|||.|.:|...|.:|||||:.|::     |.|:..|||:|.|:||||:
Human     3 DAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVA 67

  Fly   120 DILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMS 184
            |:.|::.||||.||.|.|..|.||.:.||.|..:|.:|.:.|.:||..:|.||:|||.||:.|.:
Human    68 DLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRA 132

  Fly   185 LRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHG----NAGTACVFSTEEEIWSLVGFQVS 245
            |||.|||..|:...|:        :|...|.....|:|    .|...||.:.|:.  ......|:
Human   133 LRTPRNARAAVGLVWL--------LAALFSAPYLSYYGTVRYGALELCVPAWEDA--RRRALDVA 187

  Fly   246 FFLSSYVAPLTLICFLYMGMLARLWKS-APGCKPSAESRKGKRRVT----RMVVVVVLAFAICWL 305
            .|.:.|:.|:.::...|...|..||.: .|....:||:|   ||.|    |.::.|...:|:||.
Human   188 TFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEAR---RRATGRAGRAMLAVAALYALCWG 249

  Fly   306 PIHVILVLKALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWCG 365
            |.|.:::......:..|..:...::.||.:||.|||:||::||..|.:||..||::..||
Human   250 PHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCG 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	65/165 (39%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	95/269 (35%)
GALR3	NP_003605.1	7tm_4	24..>162	CDD:304433	61/145 (42%)
		7tm_1	34..291	CDD:278431	95/269 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3617
eggNOG	1	0.900	-	-		E33208_3B9CW
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	1	1.000	-	-		FOG0000972
OrthoInspector	1	1.000	-	-		mtm9822
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1132
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820