DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and galr2b

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	XP_001339169.1	Gene:	galr2b / 798737	ZFINID:	ZDB-GENE-131121-48	Length:	378	Species:	Danio rerio

Alignment Length:	327	Identity:	122/327 - (37%)
Similarity:	186/327 - (56%)	Gaps:	28/327 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TDHSD------H-NANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQM- 105
            :||.|      | ||::|.:.:..||        ||.|.|.:|...|.:||.||:.|::.:.|:
Zfish     2 SDHEDLNKAMGHWNASESYQLNPASV--------IVSVVFSLIFLLGTIGNSLVLAVLLRSGQVG 58

  Fly   106 RSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSF 170
            .:||||.|:||:|:|..|:||||||.||.|.|..|.||:..||.|.:.|.:|.:.|.:||..:|.
Zfish    59 YNTTNLFILNLSVADFFFIIFCVPFQATIYSLEGWVFGSFMCKVVHFFINLTMYASSFTLAAVSV 123

  Fly   171 DRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEE 235
            ||:||:.:|:.|..|||..||.:|::..|...:..|.|. ||:...|...:.|   .||...||.
Zfish   124 DRYLAIRYPLRSRELRTPCNAVVAMVVIWGLSLVFAGPY-LSYYDLIDFENSN---VCVPGWEEH 184

  Fly   236 IWSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAF 300
            ...::  ....|:..||.|:.::...|...:..||.:.......:||::.||:||:|:::|.:.|
Zfish   185 NRKVL--DTCTFVFGYVIPVLIVSLSYTRTIKYLWTAVDPLDGMSESKRAKRKVTKMIIIVTVLF 247

  Fly   301 AICWLPIHVILVLKALNLYGG---SHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVV 362
            .|||||.||:::   ..|||.   :..:...:::||.:||.|||:|||:||.:|.:|||.|:||.
Zfish   248 CICWLPYHVVIL---CYLYGDFPFNQTTYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGFKKVF 309

  Fly   363 WC 364
            .|
Zfish   310 SC 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	63/157 (40%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	97/259 (37%)
galr2b	XP_001339169.1	7tmA_Gal2_Gal3_R	27..305	CDD:320225	110/294 (37%)
		TM helix 1	29..53	CDD:320225	10/23 (43%)
		TM helix 2	63..85	CDD:320225	14/21 (67%)
		TM helix 3	101..123	CDD:320225	7/21 (33%)
		TM helix 4	146..162	CDD:320225	3/15 (20%)
		TM helix 5	187..210	CDD:320225	4/24 (17%)
		TM helix 6	237..259	CDD:320225	11/21 (52%)
		TM helix 7	273..298	CDD:320225	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3501
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	1	1.000	-	-		FOG0000972
OrthoInspector	1	1.000	-	-		mtm6485
orthoMCL	1	0.900	-	-		OOG6_105726
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3950
SonicParanoid	1	1.000	-	-		X1132
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.900