DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and SSTR5

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001044.1	Gene:	SSTR5 / 6755	HGNCID:	11334	Length:	364	Species:	Homo sapiens

Alignment Length:	397	Identity:	131/397 - (32%)
Similarity:	198/397 - (49%)	Gaps:	76/397 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SW----PKASWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIV 77
            ||    |.|:.|...|.:::..:.|:|                        |.:|        :|
Human    11 SWNASSPGAASGGGDNRTLVGPAPSAG------------------------ARAV--------LV 43

  Fly    78 PVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPF 142
            ||.:.::..|||.||.|||.||:...:|::.||:.|:||||:|:|::: .:||.||......|||
Human    44 PVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYML-GLPFLATQNAASFWPF 107

  Fly   143 GNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAI 207
            |.|.|:.|..:..|....||:.|.:||.||:||||||::|...|..|.|.||...||:..:..::
Human   108 GPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSL 172

  Fly   208 PVALSHSVRIYQYHGNAGTACVFSTEEEI--WSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLW 270
            |:.:...|:       .|..|..|..|.:  |..| |.:...:..:.|||.:||..|:.::.::
Human   173 PLLVFADVQ-------EGGTCNASWPEPVGLWGAV-FIIYTAVLGFFAPLLVICLCYLLIVVKV- 228

  Fly   271 KSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLP------IHVILVLKALNLYGGSHLSVIIQ 329
             .|.|.:.....|:.:|:|||||:||||.||.||||      :::.:.|.......|.:..|:|
Human   229 -RAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVI- 291

  Fly   330 IISHVVAYTNSCINPILYAFLSDNFRKAFRKVVWC---GS-----------PPPLMTNQQVTKTT 380
                 ::|.|||.||:||.|||||||::|:||: |   ||           |..:...|:.|...
Human   292 -----LSYANSCANPVLYGFLSDNFRQSFQKVL-CLRKGSGAKDADATEPRPDRIRQQQEATPPA 350

  Fly   381 RTATGNG 387
            ..|..||
Human   351 HRAAANG 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	60/158 (38%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	94/263 (36%)
SSTR5	NP_001044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/8 (38%)
		7tm_4	54..319	CDD:304433	107/281 (38%)
		7tm_1	57..304	CDD:278431	94/263 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..364		6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010