DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and SSTR3

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001042.1	Gene:	SSTR3 / 6753	HGNCID:	11332	Length:	418	Species:	Homo sapiens

Alignment Length:	341	Identity:	108/341 - (31%)
Similarity:	165/341 - (48%)	Gaps:	42/341 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TSEHTDHSDHNANDSMEYDA--------ESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVA 101
            :|..|.....||:.:...||        .|.|...:...::|:.:.::...|||||.|||.||:.
Human     7 SSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLR 71

  Fly   102 NQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLV 166
            :....|.||:.|:|||::|.||:: .:||.|....|..||||::.|:.|..:..:....|::.|.
Human    72 HTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLT 135

  Fly   167 LMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFS 231
            :||.||:||||||..|...||...|.......|:......:||.:...|      ....:.|...
Human   136 VMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV------PRGMSTCHMQ 194

  Fly   232 TEE--EIWSLVGFQVSFFLSSYVAPLTLICFLYMGMLA-------RLWKSAPGCKPSAESRKGKR 287
            ..|  ..|. .||.:......:..||.:||..|:.::.       |:|  ||.|:   ..|:.:|
Human   195 WPEPAAAWR-AGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVW--APSCQ---RRRRSER 253

  Fly   288 RVTRMVVVVVLAFAICWLPIHVILVLKAL------NLYGGSHLSVIIQIISHVVAYTNSCINPIL 346
            |||||||.||..|.:||:|.:|:.::..:      ..:.|.:..|:      .:.|.|||.||||
Human   254 RVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVV------ALPYANSCANPIL 312

  Fly   347 YAFLSDNFRKAFRKVV 362
            |.|||..|::.||:|:
Human   313 YGFLSYRFKQGFRRVL 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	53/158 (34%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	87/270 (32%)
SSTR3	NP_001042.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		4/13 (31%)
		7tm_4	55..>158	CDD:304433	45/103 (44%)
		7tm_1	61..313	CDD:278431	87/270 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010