DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and RGR

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_002912.2	Gene:	RGR / 5995	HGNCID:	9990	Length:	295	Species:	Homo sapiens

Alignment Length:	325	Identity:	74/325 - (22%)
Similarity:	132/325 - (40%)	Gaps:	61/325 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AESVALERIVSTIVPVFFG------------IIGFAGLLGNGLVILVVVANQQMRSTTNLLIINL 116
            ||:.||        |..||            :...:||..|.|.|.......::|:..:||:::|
Human     2 AETSAL--------PTGFGELEVLAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSL 58

  Fly   117 AVSDILFVIFCVPFTATDYVL----PEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVV 177
            |::|....:..: ..||..:|    ..||:|:..|:...:...||...|:.:...:::.|:
Human    59 ALADSGISLNAL-VAATSSLLRVSHRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRY---- 118

  Fly   178 HPVTSMSLRTERNATLAIMCAWI-TIVTTAIP-VALSHSVRIYQYHGNAGTACV--FSTEEEIWS 238
            |...:.|.....:|...::..|: :....|:| :...|    |.|. ..||.|.  :|..:..::
Human   119 HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGH----YDYE-PLGTCCTLDYSKGDRNFT 178

  Fly   239 LVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAIC 303
            ...|.:|||  ::..||.:....|..|..:|.||            |..:|...:....|...
Human   179 SFLFTMSFF--NFAMPLFITITSYSLMEQKLGKS------------GHLQVNTTLPARTLLLG-- 227

  Fly   304 WLPIHVILVLKALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVVW-CGSP 367
            |.| :.||.|.|: :...:.:|..:|::..::|.....||.|.||..::...:.    :| |.||
Human   228 WGP-YAILYLYAV-IADVTSISPKLQMVPALIAKMVPTINAINYALGNEMVCRG----IWQCLSP 286

Fly 368 367
Human 287 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	35/164 (21%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	59/263 (22%)
RGR	NP_002912.2	7tmA_Retinal_GPR	17..281	CDD:320200	63/295 (21%)
		TM helix 1	18..44	CDD:320200	5/25 (20%)
		TM helix 2	51..77	CDD:320200	7/26 (27%)
		TM helix 3	92..122	CDD:320200	6/33 (18%)
		TM helix 4	130..150	CDD:320200	3/19 (16%)
		TM helix 5	177..206	CDD:320200	8/30 (27%)
		TM helix 6	208..238	CDD:320200	10/44 (23%)
		TM helix 7	248..273	CDD:320200	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840