DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and galr1b

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001314772.1	Gene:	galr1b / 561989	ZFINID:	ZDB-GENE-140624-1	Length:	350	Species:	Danio rerio

Alignment Length:	366	Identity:	137/366 - (37%)
Similarity:	200/366 - (54%)	Gaps:	36/366 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLV 95
            ::.:..|......:|.||.|     .|.:.:.....|       .||||.||.|.|.|::||.||
Zfish     2 LVIMGLSRNETVIWTEEHMD-----TNQTTDTFGPEV-------VIVPVIFGCIFFLGIIGNTLV 54

  Fly    96 ILVV--VANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTC 158
            ::|:  :.:::.|||||:.|:||:::|:.|::|||||.||.|.||||.||...||||.|.::|:.
Zfish    55 MVVIGKIKSRRSRSTTNIFILNLSIADLSFLLFCVPFQATIYSLPEWIFGAFLCKFVHYFVMVSM 119

  Fly   159 HCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGN 223
            ..|::|||.||.||::|||....|..:|..|||.:.:...|:.....|:||| .|.:........
Zfish   120 LVSIFTLVAMSVDRYIAVVLSKKSPCIRNRRNALIGVCVIWMLSFIFAVPVA-QHQILTDHPKAP 183

  Fly   224 AGTACVFSTEEEIW----SLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRK 284
            ..|.|     .|||    :...::|:..:..|:.||.||...|..:|..|.|.....  |.:|.:
Zfish   184 NSTFC-----WEIWTERVAKHTYKVTILVIGYLLPLLLITCCYAKVLYHLHKKIKNM--SKKSER 241

  Fly   285 GKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAF 349
            .||:..:.|::||.||.|||:|.|:|.:......:..:..|...:||||.:||.|||:|||||||
Zfish   242 SKRKTAQTVLLVVAAFLICWMPHHIIAMWVEFGQFPLNDASFAFRIISHCLAYGNSCVNPILYAF 306

  Fly   350 LSDNFRKAFRKVVWCG---SPPPL-------MTNQQVTKTT 380
            ||:|||||.::|..|.   ||||:       |.|..:|.:|
Zfish   307 LSENFRKACKQVFTCRFFYSPPPVEKVVRIRMENFSMTHST 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	65/162 (40%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	100/261 (38%)
galr1b	NP_001314772.1	7tm_4	45..>167	CDD:304433	54/121 (45%)
galr1b	NP_001314772.1	7tm_1	50..304	CDD:278431	100/261 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3307
eggNOG	1	0.900	-	-		E33208_3B9CW
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3501
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	1	1.000	-	-		FOG0000972
OrthoInspector	1	1.000	-	-		mtm6485
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3950
SonicParanoid	1	1.000	-	-		X1132
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900