Protein Alignment AstA-R1 and NPY4R

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 122/423 - (28%)
• Similarity: 195/423 - (46%)
• Gaps: 95/423 - (22%)

  Fly     7 LALLLATLISSWPKASWGATGNGSIISVSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALER 71
            |||||       ||:..|.       :.|...|..|.| |||...|    .|.|.:...|.::|.
Human     7 LALLL-------PKSPQGE-------NRSKPLGTPYNF-SEHCQDS----VDVMVFIVTSYSIET 52

  Fly    72 IVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYV 136
            :|              |:|||..::.|.|..::..:.|||||.|||.||.|..:.|.|.||...:
Human    53 VV--------------GVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTI 103

  Fly   137 LPEWPFGNVWCK---FVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPV---TSMSLRTERNATLAI 195
            :..|.||...||   |:|.|.|..   |:.:|||::.:|...:::|.   .|:|     .|.|.|
Human   104 MDYWIFGETLCKMSAFIQCMSVTV---SILSLVLVALERHQLIINPTGWKPSIS-----QAYLGI 160

  Fly   196 MCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEE----EIWSLVGFQVSF----FLSSYV 252
            :..|:.....::|. |::|:....:|.|...|..|..::    |.|.|...:..:    .|..|.
Human   161 VLIWVIACVLSLPF-LANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYC 224

  Fly   253 APL--TLICFLYMGMLARLWKSAPGC---------KPSAESRKG-KRRVTRMVVVVVLAFAICWL 305
            .||  .|:|:      ||:::    |         |.:...|.| .::|..::||:|:|||:.||
Human   225 LPLGFILVCY------ARIYR----CLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWL 279

  Fly   306 PIHVILVL-----KALNLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFRKAFRK-VVWC 364
            |:||...|     :|:.:..|:    :|.::.|::|..::|:||.:|.||:.||:|..:. |:.|
Human   280 PLHVFNSLEDWHHEAIPICHGN----LIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTC 340

  Fly   365 GSPPPLMTNQQV---TKTTRTATG----NGTSN 390
            ....||..::.:   |..|..:.|    :|.||
Human   341 QQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSN 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	91/313 (29%)
		TM helix 1	76..102	CDD:320224	6/25 (24%)
		TM helix 2	109..135	CDD:320224	15/25 (60%)
		TM helix 3	147..177	CDD:320224	11/32 (34%)
		TM helix 4	189..209	CDD:320224	4/19 (21%)
		TM helix 5	239..268	CDD:320224	7/34 (21%)
		TM helix 6	284..314	CDD:320224	14/35 (40%)
		TM helix 7	326..351	CDD:320224	8/24 (33%)
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	94/327 (29%)
		TM helix 1	43..69	CDD:320519	9/39 (23%)
		TM helix 2	76..101	CDD:320519	15/24 (63%)
		TM helix 3	114..144	CDD:320519	11/32 (34%)
		TM helix 4	155..176	CDD:320519	5/21 (24%)
		TM helix 5	211..240	CDD:320519	8/38 (21%)
		TM helix 6	258..288	CDD:320519	13/29 (45%)
		TM helix 7	301..326	CDD:320519	8/28 (29%)