Protein Alignment AstA-R1 and OPRL1

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 109/311 - (35%)
• Similarity: 168/311 - (54%)
• Gaps: 15/311 - (4%)

  Fly    75 TIVPVFFGI-IGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLP 138
            |||.::..: :|  |||||.||:.|::.:.:|::.||:.|.|||::|.| |:..:||..||.:|.
Human    53 TIVGLYLAVCVG--GLLGNCLVMYVILRHTKMKTATNIYIFNLALADTL-VLLTLPFQGTDILLG 114

  Fly   139 EWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIV 203
            .|||||..||.|..:.......|.:||..||.||::|:.||:.::.:||...|....:..|....
Human   115 FWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALAS 179

  Fly   204 TTAIPVALSHSVRIYQYHGNAGTACV--FSTEEEIWSLVGFQVSFFLSSYVAPLTLICFLYMGML 266
            ...:|||:..|.::    .:....|:  ..|.::.|..| |.:..||.|::.|:.:|...|..|:
Human   180 VVGVPVAIMGSAQV----EDEEIECLVEIPTPQDYWGPV-FAICIFLFSFIVPVLVISVCYSLMI 239

  Fly   267 ARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQII 331
            .|| :.......|.|..:..||:||:|:|||..|..||.|:.|.::.:.|.:...|..:|.|...
Human   240 RRL-RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRF 303

  Fly   332 SHVVAYTNSCINPILYAFLSDNFRKAFRKVVWCGSPPPLMTNQQVTKTTRT 382
            ...:.|.|||:||||||||.:||:..|||.. |.|  .|..:.||:...|:
Human   304 CTALGYVNSCLNPILYAFLDENFKACFRKFC-CAS--ALRRDVQVSDRVRS 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	100/285 (35%)
		TM helix 1	76..102	CDD:320224	11/26 (42%)
		TM helix 2	109..135	CDD:320224	12/25 (48%)
		TM helix 3	147..177	CDD:320224	11/29 (38%)
		TM helix 4	189..209	CDD:320224	2/19 (11%)
		TM helix 5	239..268	CDD:320224	9/28 (32%)
		TM helix 6	284..314	CDD:320224	13/29 (45%)
		TM helix 7	326..351	CDD:320224	13/24 (54%)
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	100/285 (35%)
		TM helix 1	53..79	CDD:320220	12/27 (44%)
		TM helix 2	86..112	CDD:320220	13/26 (50%)
		TM helix 3	123..153	CDD:320220	11/29 (38%)
		TM helix 4	165..187	CDD:320220	4/21 (19%)
		TM helix 5	212..241	CDD:320220	9/29 (31%)
		TM helix 6	256..286	CDD:320220	13/29 (45%)
		TM helix 7	298..323	CDD:320220	13/24 (54%)