Protein Alignment AstA-R1 and OPRK1

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 107/333 - (32%)
• Similarity: 177/333 - (53%)
• Gaps: 14/333 - (4%)

  Fly    53 DHNANDSMEYDA--ESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIIN 115
            |.|.:...| ||  |...:...:..|:...:.::...||:||.||:.|::...:|::.||:.|.|
Human    37 DSNGSAGSE-DAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFN 100

  Fly   116 LAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPV 180
            ||::|.| |...:||.:|.|::..||||:|.||.|..:.......|::||.:||.||::||.|||
Human   101 LALADAL-VTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPV 164

  Fly   181 TSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEEIWSLVGFQVS 245
            .::..||...|.:..:|.|:...:..|...:....::.:.......:..|..::..|..:..::.
Human   165 KALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKIC 229

  Fly   246 FFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVI 310
            .|:.::|.|:.:|...|..|:.|| ||......|.|..:..||:||:|:|||..|.:||.|||:.
Human   230 VFIFAFVIPVLIIIVCYTLMILRL-KSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIF 293

  Fly   311 LVLKALNLYGGSHLSVIIQIISHVVA--YTNSCINPILYAFLSDNFRKAFRKVVWCGSPPPLMTN 373
            ::::||.  ..||.:..:......:|  ||||.:||||||||.:||::.||...:     ||...
Human   294 ILVEALG--STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCF-----PLKMR 351

  Fly   374 QQVTKTTR 381
            .:...|:|
Human   352 MERQSTSR 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	95/284 (33%)
		TM helix 1	76..102	CDD:320224	8/25 (32%)
		TM helix 2	109..135	CDD:320224	12/25 (48%)
		TM helix 3	147..177	CDD:320224	11/29 (38%)
		TM helix 4	189..209	CDD:320224	4/19 (21%)
		TM helix 5	239..268	CDD:320224	6/28 (21%)
		TM helix 6	284..314	CDD:320224	14/29 (48%)
		TM helix 7	326..351	CDD:320224	12/26 (46%)
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	95/284 (33%)
		TM helix 1	61..87	CDD:320219	8/25 (32%)
		TM helix 2	94..120	CDD:320219	12/26 (46%)
		TM helix 3	131..161	CDD:320219	11/29 (38%)
		TM helix 4	173..195	CDD:320219	4/21 (19%)
		TM helix 5	223..252	CDD:320219	6/28 (21%)
		TM helix 6	267..297	CDD:320219	14/29 (48%)
		TM helix 7	309..334	CDD:320219	12/24 (50%)