Protein Alignment AstA-R1 and MTNR1A

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_005949.1
• Gene: MTNR1A / 4543
• HGNCID: 7463
• Length: 350
• Species: Homo sapiens
• Alignment Length: 347
• Identity: 83/347 - (23%)
• Similarity: 159/347 - (45%)
• Gaps: 74/347 - (21%)

  Fly    72 IVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYV 136
            ::.|||         ..:|||.||||.|..|:::|:..|:.:::|||:|::..|:..|.......
Human    34 LIFTIV---------VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIF 89

  Fly   137 LPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWIT 201
            ...|..|.:.|:...:::.::...|::.:..::.:|:..:.|.:....|.:.:|:...::..|:.
Human    90 NNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLL 154

  Fly   202 IVTTAIP----VALSHSVRIYQYHGNAGTACVFSTEEEIWSLVGFQVSFFLSSYVAPLTLICFLY 262
            .:...:|    ..|.:..|||        :|.|:  :.:.|  .:.::..:..::.|:.::.|.|
Human   155 TLAAVLPNLRAGTLQYDPRIY--------SCTFA--QSVSS--AYTIAVVVFHFLVPMIIVIFCY 207

  Fly   263 MGMLARLW--------KSAPGCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLY 319
            :    |:|        :..|..||..:.:..:..||..||.|:  |||||.|::.|.:..|
Human   208 L----RIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVL--FAICWAPLNFIGLAVA---- 262

  Fly   320 GGSHLSVI------IQIISHVVAYTNSCINPILYAFLSDNFRKAFRKVV---------------- 362
             ....|::      :.:.|:.:||.|||:|.|:|..|:.||||.:|:::
Human   263 -SDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSND 326

  Fly   363 ------WCGSPPPLMTNQQVTK 378
                  |  .|.|||||..|.|
Human   327 VADRVKW--KPSPLMTNNNVVK 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	73/300 (24%)
		TM helix 1	76..102	CDD:320224	10/25 (40%)
		TM helix 2	109..135	CDD:320224	7/25 (28%)
		TM helix 3	147..177	CDD:320224	3/29 (10%)
		TM helix 4	189..209	CDD:320224	3/23 (13%)
		TM helix 5	239..268	CDD:320224	3/28 (11%)
		TM helix 6	284..314	CDD:320224	12/29 (41%)
		TM helix 7	326..351	CDD:320224	9/30 (30%)
MTNR1A	NP_005949.1	7tm_GPCRs	28..306	CDD:475119	73/303 (24%)
		TM helix 1	30..54	CDD:410628	11/28 (39%)
		TM helix 2	63..85	CDD:410628	7/21 (33%)
		TM helix 3	101..123	CDD:410628	1/21 (5%)
		TM helix 4	146..162	CDD:410628	1/15 (7%)
		TM helix 5	185..208	CDD:410628	3/24 (13%)
		TM helix 6	237..259	CDD:410628	12/23 (52%)
		TM helix 7	274..299	CDD:410628	9/24 (38%)