Protein Alignment AstA-R1 and oprk1

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_001305709.1
• Gene: oprk1 / 360139
• ZFINID: ZDB-GENE-030729-1
• Length: 404
• Species: Danio rerio
• Alignment Length: 362
• Identity: 122/362 - (33%)
• Similarity: 189/362 - (52%)
• Gaps: 43/362 - (11%)

  Fly    41 NYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVF---FGIIGFAGLLGNGLVILVVVAN 102
            |:.:.|..:|..:.:.|:|...:.|:      :|.::|:.   :.::...||:||.||:.|::..
Zfish    25 NFTWQSAVSDIYNSSLNESWTTEQEA------MSPLIPIITAVYSVVFVVGLVGNCLVMYVIIRY 83

  Fly   103 QQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKF---VQYMIVVTCHCSVYT 164
            .:|::.||:.|.||||:|.| |...:||.:|||:|..||||.|.||.   :.|..:.|   |::|
Zfish    84 TKMKTATNIYIFNLAVADAL-VTTTMPFQSTDYLLNSWPFGEVVCKVFISIDYYNMFT---SIFT 144

  Fly   165 LVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACV 229
            |.:||.||::||.|||.::..||...|.:..:..|:......||..:..|.:.    .|..|.|.
Zfish   145 LTMMSVDRYVAVCHPVKALDFRTPMKAKIINILIWVLSSAAGIPAMVLGSTQT----NNGTTECA 205

  Fly   230 --FSTEEEIWSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRM 292
              |......|..: .::..|:..:||||.:|...|..|:.|| ||......|.|..:..||:||:
Zfish   206 LQFPDPYVYWDTL-MKICVFIFGFVAPLLIITVCYTLMVLRL-KSVRLLSGSREKDRNLRRITRL 268

  Fly   293 VVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQIISHVVA--YTNSCINPILYAFLSDNFR 355
            |:|||..|.:||.|||:.:::|||: :|....:.::......||  ||||.:||||||||.:||:
Zfish   269 VLVVVAVFVVCWTPIHIFILVKALS-HGVPETTSVMAAYFFCVALGYTNSSLNPILYAFLDENFK 332

  Fly   356 KAFRKVVWCGSPPPLMTNQQVTKTTRTA-TGNGTSNI 391
            :.||.....|               ||| .|.|.|.:
Zfish   333 RCFRDFCCPG---------------RTAGDGRGVSRV 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	106/292 (36%)
		TM helix 1	76..102	CDD:320224	8/28 (29%)
		TM helix 2	109..135	CDD:320224	13/25 (52%)
		TM helix 3	147..177	CDD:320224	12/32 (38%)
		TM helix 4	189..209	CDD:320224	3/19 (16%)
		TM helix 5	239..268	CDD:320224	8/28 (29%)
		TM helix 6	284..314	CDD:320224	14/29 (48%)
		TM helix 7	326..351	CDD:320224	13/26 (50%)
oprk1	NP_001305709.1	7tmA_Kappa_opioid_R	56..335	CDD:320219	106/289 (37%)
		TM helix 1	57..83	CDD:320219	7/25 (28%)
		TM helix 2	90..116	CDD:320219	14/26 (54%)
		TM helix 3	127..157	CDD:320219	12/32 (38%)
		TM helix 4	169..191	CDD:320219	4/21 (19%)
		TM helix 5	216..245	CDD:320219	8/29 (28%)
		TM helix 6	260..290	CDD:320219	14/29 (48%)
		TM helix 7	303..328	CDD:320219	13/24 (54%)