DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and mchr1a

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	XP_001343144.1	Gene:	mchr1a / 353181	ZFINID:	ZDB-GENE-030502-4	Length:	353	Species:	Danio rerio

Alignment Length:	328	Identity:	91/328 - (27%)
Similarity:	154/328 - (46%)	Gaps:	35/328 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DHSDHNANDSMEYDAESVALERIVST-------IVPVFFGIIGFAGLLGNGLVILVVVAN---QQ 104
            |..:.:.|.|:.....|..::  |:|       |:|..||||.|.|:.||.:|:..::..   |.
Zfish     2 DFPEDSENSSLRLSNSSKQIQ--VNTDDQYGNAILPSIFGIICFLGISGNSIVVYTIIKKTKCQA 64

  Fly   105 MRSTTNLLIINLAVSDILFVIFCVPFTATDYV-LPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLM 168
            .::..::.|.||::.|:||:: .:||.....: ...|.||...||.:..:...:...|.|.|.:|
Zfish    65 KQTVPDIFIFNLSIVDLLFLL-GMPFLIHQLLGNGSWCFGATMCKVISALDSNSQTVSTYILTVM 128

  Fly   169 SFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTE 233
            :.||::|.|||.....:||...|:..:...|...:.:..|| |.::..:..:.|..|  |.....
Zfish   129 TLDRYVATVHPFRFNHVRTTCVASAVVAAVWALSLISITPV-LMYTGLMPLHSGQVG--CALLLP 190

  Fly   234 EEIWSLVGFQVSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVL 298
            ....::..|.:..|:.::..|||:||.::..:|..:..:.....|..:..:.| .||||.|.:.|
Zfish   191 NPSTNICWFTIYQFVLAFALPLTIICVVFFKILKHMSTTVAPLPPRNQQVRTK-SVTRMAVAICL 254

  Fly   299 AFAICWLPIHVILVLKALNLYGGSHL-----SVIIQIISHV---VAYTNSCINPILYAFLSDNFR 355
            ||.|||.|.:::.::         ||     |.....:.||   :.|.||||||.||..||..|:
Zfish   255 AFFICWAPYYILQIV---------HLGIQKPSASFYYVYHVAISMGYANSCINPFLYIILSKTFK 310

  Fly   356 KAF 358
            :.|
Zfish   311 RQF 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	41/160 (26%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	71/267 (27%)
mchr1a	XP_001343144.1	7tm_GPCRs	33..313	CDD:333717	84/293 (29%)
		TM helix 1	34..58	CDD:320095	10/23 (43%)
		TM helix 2	70..91	CDD:320095	8/21 (38%)
		TM helix 3	108..130	CDD:320095	5/21 (24%)
		TM helix 4	153..169	CDD:320095	1/15 (7%)
		TM helix 5	197..220	CDD:320095	7/22 (32%)
		TM helix 6	243..268	CDD:320095	13/25 (52%)
		TM helix 7	281..306	CDD:320095	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100