DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R1 and GPR149

DIOPT Version :9

Sequence 1:	NP_524700.1	Gene:	AstA-R1 / 44126	FlyBaseID:	FBgn0266429	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001033794.1	Gene:	GPR149 / 344758	HGNCID:	23627	Length:	731	Species:	Homo sapiens

Alignment Length:	442	Identity:	79/442 - (17%)
Similarity:	153/442 - (34%)	Gaps:	166/442 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VSNSSGNNYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFF---GIIGFAGLLGNGLV 95
            :||.|.|:.:...|     :||:.|          |.....|:....|   .::.||.|:|: :.
Human     5 LSNLSTNDSSLWKE-----NHNSTD----------LLNPPGTLNIYLFCLTCLMTFAALVGS-IY 53

  Fly    96 ILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYM-----IV 155
            .|:.:...|.|:..::|:.:.:|.|::.|:     :.|.::..:||  |....:.|::     ::
Human    54 SLISLLKMQNRTVVSMLVASWSVDDLMSVL-----SVTIFMFLQWP--NEVPGYFQFLCTTSALM 111

  Fly   156 VTCH---CSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATL-AIMCAW-ITIVTTAIPVALSHSV 215
            ..|.   .::...:|:|:: |..:...|.|.:........| .::..| .:::.:|:|:
Human   112 YLCQGLSSNLKATLLVSYN-FYTMHRGVGSQTASRRSGQVLGVVLTVWAASLLLSALPL------ 169

  Fly   216 RIYQYHGNAGTACVFSTEEEIWS-LVGFQVSFFLSSYVAPLTLICFLYMGMLARLW--------- 270
                    .|......|.   |. ||...     ||||..|:::..|..|:|..|.
Human   170 --------CGWGAFVRTP---WGCLVDCS-----SSYVLFLSIVYALAFGLLVGLSVPLTHRLLC 218

  Fly   271 -----------------------------------KSAP--------GCKPS------------- 279
                                               :.||        ||.||
Human   219 SEEPPRLHSNYQEISRGASIPGTPPTAGRVVSLSPEDAPGPSLRRSGGCSPSSDTVFGPGAPAAA 283

  Fly   280 -AESRKGKRRVT--------------RMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQ 329
             ||:.:.:.|.|              |..:::.|...:.|||:.:.:|::  |:.|  ..|:.::
Human   284 GAEACRRENRGTLYGTRSFTVSVAQKRFALILALTKVVLWLPMMMHMVVQ--NVVG--FQSLPLE 344

  Fly   330 IISHVVAYTNSCINPIL---------------------YAFLSDNFRKAFRK 360
            ..|.::....:.:.|:.                     ||..||. :|..||
Human   345 TFSFLLTLLATTVTPVFVLSKRWTHLPCGCIINCRQNAYAVASDG-KKIKRK 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tm_4	83..>240	CDD:304433	29/167 (17%)
AstA-R1	NP_524700.1	7tm_1	91..347	CDD:278431	58/367 (16%)
GPR149	NP_001033794.1	7tmA_GPR149	35..374	CDD:320139	62/373 (17%)
		TM helix 1	35..61	CDD:320139	6/26 (23%)
		TM helix 2	67..92	CDD:320139	5/29 (17%)
		TM helix 3	105..135	CDD:320139	4/30 (13%)
		TM helix 4	150..170	CDD:320139	4/33 (12%)
		TM helix 5	196..221	CDD:320139	4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..271		5/36 (14%)
		TM helix 6	303..333	CDD:320139	6/29 (21%)
		TM helix 7	341..366	CDD:320139	2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..526
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100