Protein Alignment AstA-R1 and HTR5A

DIOPT Version :10

• Sequence 1: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Sequence 2: NP_076917.1
• Gene: HTR5A / 3361
• HGNCID: 5300
• Length: 357
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 70/354 - (19%)
• Similarity: 134/354 - (37%)
• Gaps: 75/354 - (21%)

  Fly    57 NDSMEYD--AESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVS 119
            |.|:..|  ..|..|..:...::....|.:..|....|.||:..::..:......:.|:.::|||
Human    21 NHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVS 85

  Fly   120 DILFVIFCVPFTATDYVL-PEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSM 183
            |:|.....:|.:....:. ..|..|...|:......|:.|..|::.:..::.||:.::...: ..
Human    86 DVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHM-EY 149

  Fly   184 SLRTER---NATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEE--IWSLVGFQ 243
            :|||.:   |..:|:..|...:::.| |:.....    :.:......|..|.|..  ::|.||
Human   150 TLRTRKCVSNVMIALTWALSAVISLA-PLLFGWG----ETYSEGSEECQVSREPSYAVFSTVG-- 207

  Fly   244 VSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRK------------------------ 284
             :|:|     ||.::.|:|       ||.....|....|||
Human   208 -AFYL-----PLCVVLFVY-------WKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVF 259

  Fly   285 -------------------GKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYGGSHLSVIIQI 330
                               .::|...||.:::..|.:||:|..:..::..|   ....:..|.:.
Human   260 TVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPL---CSCDIPAIWKS 321

  Fly   331 ISHVVAYTNSCINPILYAFLSDNFRKAFR 359
            |...:.|:||..||::|...:.|:..||:
Human   322 IFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	63/331 (19%)
		TM helix 1	76..102	CDD:320224	5/25 (20%)
		TM helix 2	109..135	CDD:320224	7/25 (28%)
		TM helix 3	147..177	CDD:320224	6/29 (21%)
		TM helix 4	189..209	CDD:320224	4/22 (18%)
		TM helix 5	239..268	CDD:320224	8/28 (29%)
		TM helix 6	284..314	CDD:320224	8/72 (11%)
		TM helix 7	326..351	CDD:320224	8/24 (33%)
HTR5A	NP_076917.1	7tmA_5-HT5	41..349	CDD:320451	63/331 (19%)
		TM helix 1	42..68	CDD:320451	5/25 (20%)
		TM helix 2	75..101	CDD:320451	7/25 (28%)
		TM helix 3	114..144	CDD:320451	6/29 (21%)
		TM helix 4	156..177	CDD:320451	4/21 (19%)
		TM helix 5	197..226	CDD:320451	12/43 (28%)
		TM helix 6	278..308	CDD:320451	7/29 (24%)
		TM helix 7	317..342	CDD:320451	8/24 (33%)